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Subjective effects of ampakines

Reminisant B

Reminisant B

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What would an ampakine drug subjectively feel like?

http://en.wikipedia.org/wiki/CX717

Modafinil? or maybe more piracetam.

I guess it is unlikely many people have tested them, those that have might not know anyway. Interesting to know what effects actually feel like though.

Anyone have a best friends sisters cousin once removed friend who knows anything of the subjective effects?
 
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The first time I have used this compound I took about 300mg. It was a little bit exciting, the waiting for the action to take place. I have expected it to be similar to Modafinil, perhaps also because of the modulation of the glutamergic pathway. It is different, they may be some aspects these two share, but Modafinil is definately more promoting wakefullness and motivation, especially the last one may be caused through the involvation of the dopamine, which is not present in Ampalex so far as I know. Taking Modafinil, you feel clearly after 2 hours that you are "on" some psychic active agent. Ampalex is different here, after 1 hour of ingestion, one feels something taking place (you know what I mean, a change in your feeling, thoughts, for example when you feel hyperactive on coffein) but it is much more slight. Even with 600mg (the dose I use usually now) one does not feel "high" or strongly affected, the psychic sideffects are not so strong present as with other pharmaceuticals.

But there is a change, it is really difficult for me to describe it, I only can try. I can notice it when I am learning something or I have to understand correletions between some mechanism (for example in molecular biology etc.) to visualize the things I hear in the university or I read about. Sometimes the effect on the memory is very strong noticable, especially after learning for tests. The cognition is enhanced but not on the way it happens with modafinil (or higher dosages of modafinil). With modafinil one sometimes has a kind of thinking that is very concentrated, but it can dimnish the outside thinking, you focus on one way towards a solution and don`t see the others (as I sad difficult to describe), one would say that the phantasy is a little bit limited, if this is the right word for that. With Ampalex this is not the case, much more it may be helpfull to see other ways, to combine the learned informations and to see the links between issues. For me it was also interesting to notice, that the effect wasn`t very strong on the first day but it was on the second and stronger on the third one. I don`t know if this is caused by the growth factors or by some other mechanism.
Now I am using often a mixture of just a small ammount of modafinil (never more then 50mg, usually 30-40mg) and 600mg Ampalex. Sometimes adding green tee.
Modafinil gives me the state of totally wakefullness, which combined with the effects of Amaplex are simply great allowing one unbelievable concentration and allow an easier understanding and memorizing of the lectures.

I have tried many nootropics and although I know that here are enough enthusiasts who don`t want to hear this and will come up with the argument that I should not compare myself to all other people (what works for you won`t work for someone else and so on and on....) I have to say, that I have only used 2 or 3 that have ever worked.
Modafinil, Ampalex and perhaps green tee as addition to those 2. Everything else was totaly useless or even caused a state, where my abilities were more dimnished than enhanced. Perhaps are my claims higher, but the nootropic market is, as I have mentioned before a little bit absurd, giving nearly any psychological active agent the word "nootropic" as an attachment. So this is how I want to end this short report. You want me in the end to say if I think ampalex works.
And in my subjective opinion I can say: Yes, it does.

http://www.imminst.org/forum/index.p...9&t=14847&st=0
 
From wikipedia entry for "Ampakine"
Unlike earlier stimulants (e.g. caffeine, methylphenidate (Ritalin®), and the amphetamines), ampakines do not seem to have unpleasant, long-lasting side effects such as sleeplessness.

They are currently (2005) investigated as potential treatment for a range of conditions involving mental disability such as Alzheimer's disease, Parkinson's disease, schizophrenia or neurological disorders as Attention Deficit Hyperactivity Disorder (ADHD), among others. In a 2006 study they were shown to have an effect after they had left the body, continuing to enhance learning and memory.
Click to expand...

That sounds pretty promising. Less of a crash.
 
They appear to be the cleanest form of stimulant/cognition enhancers with the preferred variants (all ampakine are NOT the same) and no real sides or tolerance issues

if anyone has research interest in them they can contact me for more info %)
 
My best friends sisters cousin once removed friend's baby's momma's brother took CX516 daily for 12 weeks this spring. The impact was immediate. "At the start of the trial, I could remember less than five words out of a list of 20. By the second week, I could get 14 out of 20. There was a very, very appreciable enhancement." He has since finished his part in the study and says it was "heartbreaking" to go off the drug. "I've been thinking of some other way to get it, and I don't give a damn if it's legal or illegal
 
LuxEtVeritas said:
My best friends sisters cousin once removed friend's baby's momma's brother took CX516 daily for 12 weeks this spring. The impact was immediate. "At the start of the trial, I could remember less than five words out of a list of 20. By the second week, I could get 14 out of 20. There was a very, very appreciable enhancement." He has since finished his part in the study and says it was "heartbreaking" to go off the drug. "I've been thinking of some other way to get it, and I don't give a damn if it's legal or illegal
Click to expand...

i just think that its amazing that your ' best friends sisters cousin once removed friend's baby's momma's brother took CX516' and yet amazingly you seem to have experienced the effects......!!!!!

now thats some cool shite!!!!!%) 8) ;)
 
Wait, wait, wait. Heartbreaking due to dependence or extreme noticeable changes?
 
i believe one can infer it was due to being "addicted" to the cognitive and performance enhancement benefits, not in any way a physical addiction, but can be somewhat psychological --
 
I have wanted to try this compound for years--ever since I first heard about the preclinical papers about the prototypes is this series (e.g. CX614), I was enthralled. Does anyone know the chemical structure of CX717? The only place I've ever heard of some the rarer AMPAkine structures being published is the super-pricy journal 'Future Drugs.' I can see why trying this compound could be depressing--it is probably expensive, with limited availability. Saying goodbye is always the hardest part.

This is what really got me with pramiracetam. I loved that chemical, but now the window is closed and it is no longer available (and it was damn expensive when it was available).
 
Reminisant B said:
The discussions tab on the wikipedia article on CX717 has some interesting theories:

http://en.wikipedia.org/wiki/Talk:CX717

amide ring closed version of 1-(2,1,3-benzoxadiazol-5-ylcarbonyl)piperidine
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aka farampator, 1-(benzofurazan-5-ylcarbonyl) piperidine

farampator had side effect issues in late stage clinicals but i believe that was likely attributable to using too high a dose (why they did that i have no clue as it would have from indication of prior assay appeared to be too high IMO)

so this may be a more stable form of farapator as the amide closed ring variant, which would increase oral potancy even more likely....
 
Aniracetam is an ampakine, too. I guess same with some others of the racetam familiy but not really sure about that.
 
It was my understanding that racetams *weren't* AMPAkines, but that the ampakines are structurally related.
 
aniracetam is an exceptionally weak ampakine and not practical for any real effects of that nature hence IMO should not be classed as one
 
Ketamine is an ampakine. gultamate antagonism is just one thing it does on the pathway to the ampa receptors. As is Lamictal, albiet it is weak.
 
What do you mean when you say ketamine and lamotrigine are weak AMPAkines? Do you mean that the two have some direct agonist effect at AMPA receptors, because I have never heard of that. Or, perhaps you mean that certain NMDA blockers and antidepressants increase the synaptic concentration of AMPA receptors and the ratio of AMPA to NMDA receptors?

I would be interested in any papers on the topic, as I take lamictal (and I know at least a couple other of people here do as well).
 
Middleway said:
Ketamine is an ampakine. gultamate antagonism is just one thing it does on the pathway to the ampa receptors. As is Lamictal, albiet it is weak.
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AFAIK, neither of these drugs are ampakines. They may have an effect on the nt's in the system, but that doesn't make the ampakines in any way resembling what the word is meant to cover.
 
Looked for ages, can't find where I saw it, maybe I misinterpreted what it said, hmmm but I am sure it did. Anyway...
 
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