• 💊 OTHER DRUGS 💊 Welcome Guest
    Posting Rules Bluelight Rules
    Notable Threads 1 Notable Threads 2
    Dangerous Combos Addiction Support
    Emergency Services Benzo Guide v.1
    Addiction Stories Scary Case Studies
    Biology, Pharmacology & Drugs 101
  • Select Your Topic Then Scroll Down
    Alcohol Bupe Benzos
    Cocaine Heroin Opioids
    RCs Stimulants Misc
    Harm Reduction All Topics Gabapentinoids
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums

Bupe study on half-life of IV bupe

J

jm357357

Greenlighter
Joined
Jul 1, 2010
Messages
27
I have recently been hearing a lot of differing opinions on bupe's half-life when IV'd, I was doing some research and found this study:

http://www.naabt.org/documents/buprenex_PI.pdf

It clearly shows a mean half-life of 2.2 hours
(with a range of a little over 1 hour to almost eight). I have personally noticed that after taking 2mgs 4x one day through this route and easily breaking through twelve hours after last dosage. But I keep hearing people say that ROA does not matter much when it comes to half life. If it truly does have this effect when IV'd how would this effect dosing protocol, and is there any possibility of OD'ing by using this method? Because I know this would end up being a very attractive option to people that are using bupe but still chipping with their DOC.

I edited this: I originally posted the wrong link which used dosages of 0.3mg, this study uses 1.2mgs http://jat.oxfordjournals.org/content/20/6/369.full.pdf
 
jm357357 said:
I have recently been hearing a lot of differing opinions on bupe's half-life when IV'd, I was doing some research and found this study:

http://www.naabt.org/documents/buprenex_PI.pdf

It clearly shows a mean half-life of 2.2 hours
(with a range of a little over 1 hour to almost eight). I have personally noticed that after taking 2mgs 4x one day through this route and easily breaking through twelve hours after last dosage. But I keep hearing people say that ROA does not matter much when it comes to half life. If it truly does have this effect when IV'd how would this effect dosing protocol, and is there any possibility of OD'ing by using this method? Because I know this would end up being a very attractive option to people that are using bupe but still chipping with their DOC.

I edited this: I originally posted the wrong link which used dosages of 0.3mg, this study uses 1.2mgs http://jat.oxfordjournals.org/content/20/6/369.full.pdf
Click to expand...

Just FYI...the first link you provided is not a study, it is a drug guide for administration of Buprenex which is the injectable form of buprenorphine. It comes in doses of .3mg per mL.

And yes, looking at the study you provided (the second link) it definately shows that there is a much shorter half life when using bupe by IV. What exactly is your question about ODing per this information? I'm not sure I understand what you are asking and I would like to help!
 
I use buprenorphine IV, I find it does have a shorter half-life when used this way. I dose twice a day, once when I wake up and once in the late afternoon. Some times when I wake up before I take my dose I feel some mild withdrawal symptoms. For me it seems the half-life of IV bupe is between 10-16 hours, compared to the 24-36 hour half-life of sublingual bupe. It surprised me that the link said that the average half life of buprenex was 1-2.2hrs, that seems way too short. It could be because of the very low dose (.3mgs) but I'm not sure.

What you're asking about dosing, when using bupe IV you only need about a quarter of what you would if you were taking it sublingually. I'm not really sure what you're asking about ODing, but if you have an opiate tolerance, it would be pretty hard to OD on bupe, I don't know if it would even be possible. Someone with no tolerance though shouldn't take more than 1mg.
 
I forgot to write it out fully, sorry. I meant that if someone is assuming that it has the same half-life as other ROAs and then tries to break through it with their DOC and takes a much larger amount it could mean trouble. I would think that even if someone used a fairly large amount IV (like 4mgs) that 24 hours later maybe they shouldn't try to take a ton extra of there DOC. I also thought it was interesting that both studies suggested the same half-life even though one used 1/4 the dose.
 
It's always a bad idea to use much more of your DOC than you normally would. Just wait a couple days til the bupe is out of our system.
 
Deidra..it doesn't say the half life is 1 to 2 hours....it says it ranges fro 1.5 to 8 hours. And half life is not the same as when you feeling the drug wears off (you said 12 hours later you experience mild withdrawals..that just means the amount of drug in your body has diminished enough you are beginning to feel WDs).

OP..you don't have to wait til the bupe wears completely off to take other meds. Yes, some people take large doses attempting to break through the bupe so I guess if you IV bupe that could be an issue. I take other meds on top of my bupe all the time (though I take a much lower dose of bupe than most people). I normally start out at whatever my regular dose of drugs would be if I weren't taking bupe..if that doesn't do the trick then I take some more.I guess that would be my suggestion..to go slow and start low...I know it messes up the initial rush sometimes...but better than being dead.

*edit*

Ok I just woke up so shouldn't be posting til my brain is clear! Had started this post before I fell asleep and just started up again as soon as I woke up. I need to reiterate that the amount I take is not really a blocking dose...no more than 2mg. If I take 2mg IV I usually wait about 6 hours before I take oxy or whatever just in case...that way its not wasting some of it.
 
^missmeyet, my bad I guess I skipped that part. And I don't mean to be a dick but it's deiDARA, not deidra like some redneck lol.. deidara is a japanese name. For some reason people keep calling me deidra and its starting to piss me off =D
 
I find drugs administered IV to last exactly as long as when administered any other way. Minus the first hour of "come up" of course. The same goes for buprenorphine. Actually, an IV dose of bupe would last me longer than the same dose administered any other way, probably due to much increased BA.
 
I IV my bupe all the time and notice ZERO shorting of HL. I can easily go days without a dose and feel fine.

I took my last dose a hour ago and I could go until Sunday before Id start feeling uncomfortable.
 
I always felt withdrawal symptoms the same amount of time after dosing bupe no matter the ROA. So, though I have read those studies dictating the much shorter half-life of IV bupe, I've never experienced it. You'd think if that was really the case and it really was such a great difference in half-life that people dependent on bupe would get sick much faster if they IV it than if they dose sublingually but I've never seen that to be true with myself or anyone I know.
 
deidara said:
^missmeyet, my bad I guess I skipped that part. And I don't mean to be a dick but it's deiDARA, not deidra like some redneck lol.. deidara is a japanese name. For some reason people keep calling me deidra and its starting to piss me off =D
Click to expand...

I apologize girl..I will for sure make not of it..I usually tend to be careful of that because IRL people have mispronounced and spelled my name my whole life.

I agree as far as I do not notice IV bupe wearing off any faster. It did compare it to several other studies that came up with pretty much same data so I don't know what the deal is. I just know that I have no problem taking other opiates/opioids 6 or 7 hours after an injection of bupe. But maybe because it is such a small dose that I inject.
 
You must log in or register to reply here.
Top