"Study of bipathic effect of phenazepam." What?

[golden1]

http://www.springerlink.com/content/435528t0pwj40u47/

Phenazepam in ultralow doses significantly potentiated anxiolytic and anticonvulsant effects of therapeutic doses of the same drug both after preliminary or simultaneous administration, which attests to bipathic action of phenazepam. The combination of ultralow and therapeutic doses of phenazepam prevented the development of its specific myorelaxant and sedative side effects.

I can only read the first page and it isn't making any logical sense to me. Can anyone explain or take some guesses? I dont understand how a super small dose of phenazepam before taking a normal dose would reduce side effects and enhance the other effects? Also, bipathic? Is this real science or what?

 

[golden1]

http://resources.metapress.com/pdf-preview.axd?code=m2k0285174823603&size=largest

Experiments on male outbred albino rats showed that benzodiazepine tranquilizers phenazepam and flunitrazepam in ultralow doses (10-9-10-15 mol/kg) produced an anxiolytic effect in the conflict situation test. This effect was not accompanied by myorelaxing and sedative side effects typical of standard doses of tranquilizers.

even more confused lol

http://www.springerlink.com/content/j31124026578v026/

Phenazepam in ultralow doses produced an anxiolytic effect on male outbred albino rats in the conflict situation and elevated plus-maze models and inhibited q-activity in EEG, which is typical of tranquilizers. As differentiated from standard doses, phenazepam in this concentration did not affect other frequency bands. Our results suggest that phenazepam in ultralow doses acts as the anxioselective tranquilizer.

http://www.ncbi.nlm.nih.gov/pubmed/12881980

The conclusion is made, that the action of the drugs injected in supersmall doses is an universal property of psychotropic drugs. When administered in supersmall doses the pharmacological substances still exert their specific activity, but are devoid of side effects.

... lol the studies you find when you look up phenazepam! those russians

http://www.springerlink.com/content/p07058l40480t612/

In vitro incorporation of tranquilizer phenazepam in a concentration of 10-13 M into membrane fraction from mouse brain produced a prooxidant effect. In concentrations of 10-5-10-9 and 10-15-10-17 M this agent possessed antioxidant activity. Phenazepam significantly decreased the maximum rate of enzymatic reactions (10-5 and 10-15 M) and Michaelis constant (10-5 M) for acetylcholinesterase. Incorporation of phenazepam in ultralow doses into membrane modified its lipid components (estimated by lipid peroxidation) and functional state, and this effect was comparable with the influence of this substance in standard doses. This probably contributes to the physiological effect of ultralow doses of phenazepam in.

 

[skillet]

"A mixture of homeopathic dilutions C12+C30+C200 corresponding to 10^-27 M, 2.5 mL/kg."

Say no more 8(

 

[Hammilton]

because of the word homeopathic?

 

[skillet]

Well yeah, and because 10^-27 M! That's a single molecule per 1,600L of solution, or a 1 in 640,000 chance that a 2.5mL dose will contain a molecule. That's not ultra low dose, it's literally nothing,

 

[atrollappears]

Well, in other news, apparently saline is an effective anxiolytic devoid of side effects 8)