Hi,
I have been using Tramadol too frequently for my liking due to its amazingly fast AD effect (I am not too keen on the opioid-like effect from the mu agonism). Anyway, having read about the metabolism of Tramadol via the different enzymes and in an attempt to boost the survival of the parent drug (tramadol) instead of the metabolising into O-desmethyltramadol, I have ingested 750 mls of white grapejuice 24 hours prior to dosing a typical dose of 200mgs. Since one of the enzymes responsible for its metabolism is CYP3A4, I wanted to see if it would work.
Well, after a typical and common dose of 200mgs on empty stomach, I am finding that Tramadol's 5HTP releasing and NE reuptake properties have been profoundly potentiated. Typically, at 2 hours post ingestion I would start feeling the conversion of tramadol into the O-desmethyl version yet I am feeling at aprox T: +2.30, with a very agitated sensation and uncomfortable head high. Jaw tension is increased as so is agitation, so much that I am fearing of seizure activity as my muscles are twitching much more than commonly with this dose. My pupils are slightly more enlarged than usual so I am wary of any serotonin toxicity (I have cyproheptadine and benzodiazepines at hand). I did once experiment with this same susbatnces but at a dose of only 100mgs of Tramadol and again, found a very strong potentiation of the parent drug.
In any case, and due to the lack of literature regarding this matter, I am reporting this and would actually like to get some discussion going on and/or feedback on this mechanism of action and Tramadol's overall AD affinity, which I find is not as much discussed as its opioid effect. I would have otherwise posted this in trip reports but would like to have an open discussion in the aforementioned topics.
Thanks
I have been using Tramadol too frequently for my liking due to its amazingly fast AD effect (I am not too keen on the opioid-like effect from the mu agonism). Anyway, having read about the metabolism of Tramadol via the different enzymes and in an attempt to boost the survival of the parent drug (tramadol) instead of the metabolising into O-desmethyltramadol, I have ingested 750 mls of white grapejuice 24 hours prior to dosing a typical dose of 200mgs. Since one of the enzymes responsible for its metabolism is CYP3A4, I wanted to see if it would work.
Well, after a typical and common dose of 200mgs on empty stomach, I am finding that Tramadol's 5HTP releasing and NE reuptake properties have been profoundly potentiated. Typically, at 2 hours post ingestion I would start feeling the conversion of tramadol into the O-desmethyl version yet I am feeling at aprox T: +2.30, with a very agitated sensation and uncomfortable head high. Jaw tension is increased as so is agitation, so much that I am fearing of seizure activity as my muscles are twitching much more than commonly with this dose. My pupils are slightly more enlarged than usual so I am wary of any serotonin toxicity (I have cyproheptadine and benzodiazepines at hand). I did once experiment with this same susbatnces but at a dose of only 100mgs of Tramadol and again, found a very strong potentiation of the parent drug.
In any case, and due to the lack of literature regarding this matter, I am reporting this and would actually like to get some discussion going on and/or feedback on this mechanism of action and Tramadol's overall AD affinity, which I find is not as much discussed as its opioid effect. I would have otherwise posted this in trip reports but would like to have an open discussion in the aforementioned topics.
Thanks
