stress neurochemicals and thier antagonists

[thisusername]

stress can cause detrimental effects on the brain and body. What neurochemicals cause stress and what are some antagonist of said neurochemicals.

 

[The Monkey Mantra]

ACTH, Cortisol, CRF-1, CCK... anyone got any more? There are antagonists for CCK (proglumide) and CRF-1 (a few, not marketed yet). The CRF-1 antagonists are putative antidepressants. Keep in mind that the standard-issue SSRI's and stuff like tianeptine do a respectable job at reversing the neurotoxic effects of stress on the hippocampus.

 

[Tsukasa]

Norepinephrine and epinephrine- antagonized by alpha and beta blockers

Cortisol - ???

 

[mitragyna]

ACTH, Cortisol, CRF-1, CCK... anyone got any more? There are antagonists for CCK (proglumide) and CRF-1 (a few, not marketed yet). The CRF-1 antagonists are putative antidepressants. Keep in mind that the standard-issue SSRI's and stuff like tianeptine do a respectable job at reversing the neurotoxic effects of stress on the hippocampus.

Another interesting thing about Cholecystokinin I just found out about: "Recent evidence has suggested that it also plays a major role in inducing drug tolerance to opioids like morphine and heroin, and is partly implicated in experiences of pain hypersensitivity during opioid withdrawal.[1][2]"

 

[The Monkey Mantra]

Mitragyna, indeed it is. You can definitely prescribe someone a CCK antagonist an prevent morphine tolerance. It works, for a limited amount of time, before you just get tolerant to the antagonism. Ain't no way off the hedonic treadmill!

 

[Limpet_Chicken]

ACTH release is suppressed by some glutethimide analogs, not that one wishes to fucvk about with anticancer meds NH-glutethimide)