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stomach ulcers and drugs and alcohol

i got a stomach ulcer twice when i used to munch pills every weekend, once after 12 in one night, the last 2 containing glass which obviously aggravated things lol.

have you tried any other form of medication to treat it?
i was incredibly sick the second time and had to head to hospital for IV somac (Pantoprazole) after puking bile for most of a day, a week in bed and i was well enough to go back to work, but had to stay away from things like processed meat (ie. salami) and basically ate wheatbix, fruit and vegies for a few weeks.

i also tried pariet, but i think the somac was better, the anti nausea pills they gave me knocked me around more than the ulcer itself lol.

i'd be weary of any drugs if your still healing and want to enjoy your holiday, even to this day if i take a nasty NSAID (ie. mobic) i can have a fair bad reaction.
if you are confident you know whats in the pills, might be a different story though - i've no idea how MDMA on its own would effect things, but i'd still take it easy regardless.

i don't know what caused my initial problems to start with, i've never smoked tobacco, don't drink and was only doing pills at the time and had been for a solid year or two.
 
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Sorry this may seem not harm reduced, but i suggest taking codeine OTC instead of nsaids like nurofen plus, but MDMA high imo Just do it. Deal with any/if consequences later.

Mushies...fucked if I know but, I cant see it worsening anytrhing since your on the meds to fix it, and the fungi is really an antibiotic (CORRECT ME IF IM WRONG PLEASE) unless your inducing copius amounts I cant see a problem with any of the two mentioned.

As long as you know your md is what it is ists extensivly metabolised in the liver and excreted through the kidneys, cant see it hasving an effect on your stomach if you on the meds to counteract it.

Mushies I dunno, I just say imo, Ibuprofin must be worse for you than somthing grown in dirt/wherever.(gods creation). Maybe eat lots before consuming either. imo i wouldnt bother, but thats me n im a dick head.

Sorry prob not much help, but seriously cant see MD HIGH making ulcers worse, n if it does, it's probly worth it anyways... Sorry not much HR here but just my drunken anticts again.
 
lol your drunken ramblings are alright, should write a book and become a wordsmith
 
psytaco said:
i just don't want the worst case scenario of the ulcer getting so badly damaged that it leads to a hole in my stomach and I need emergency surgery. I'll be in the US and that kind of surgery would financially cripple me.
Click to expand...

Hope you have taken out travel insurance that comes with good medical cover. Worth the few hundred bucks...believe me :)
 
I always drink alcohol to potentiate codeine (CWE).

I've noticed problems with nurofen & panadol CWE. With panadol I get liver pain which is quite scarey, as well as pain in GIT (Gastrointestinal tract). I have no idea what part of GIT is in pain but it's bad in the morning.

With nurofen I do not get liver pain!!! , which is a positive but I do get GIT pain maybe a little worse than panadol.

I do 2 things to try and make the situation safer. I take an antacid (mylanta2go double strength) & I drink a lot of water. The water Idea I got from the directions on one of the nurofen generic packs. Said something about take with food or a large glass of water. I also do not touch alcohol for at least an hour, I try for 1hr & a half.

Anyway I"M still in pain the next morning, so maybe none of that helps very much, but the pain goes away after a day, and the symptoms dont' get worse wtih every CWE so I think things are ok with my GIT. lol git.
 
^ If you are really worried, then you could speak to your doctor and see if you could be prescribed a proton-pump inhibitor (PPI) such as Somac (pantoprazole) or Losec (omeprazole).

You can buy pantoprazole and omeprazole over the counter now, but they are expensive and PPI's need to be used for at least a week to start getting a decent reduction in gastric acid.

Otherwise, you could try using a H2 specific antagonist, like Zantac (ranitidine), which are less expensive but also less effective.
 
^ and just adding for those who don't know, both PPIs and H2-antagonists are stronger than antacids
 
bobbydarren said:
I always drink alcohol to potentiate codeine (CWE).

I've noticed problems with nurofen & panadol CWE. With panadol I get liver pain which is quite scarey, as well as pain in GIT (Gastrointestinal tract). I have no idea what part of GIT is in pain but it's bad in the morning.

With nurofen I do not get liver pain!!! , which is a positive but I do get GIT pain maybe a little worse than panadol.

I do 2 things to try and make the situation safer. I take an antacid (mylanta2go double strength) & I drink a lot of water. The water Idea I got from the directions on one of the nurofen generic packs. Said something about take with food or a large glass of water. I also do not touch alcohol for at least an hour, I try for 1hr & a half.

Anyway I"M still in pain the next morning, so maybe none of that helps very much, but the pain goes away after a day, and the symptoms dont' get worse wtih every CWE so I think things are ok with my GIT. lol git.
Click to expand...

keep an eye on that. the last thing you need is some sort of gastrointestinal infection or liver problems.

combining paracetamol and alcohol is supposed to be quite bad for your liver, so maybe cut out the alcohol.

on the plus side, at least your doing CWEs.

be careful dude, seriously this stomach ulcer is pissing me off and stopping me getting excited about my trip because I know that I can't have the kind of fun I would have if I didn't have it. Imagine a holiday where you can't drink:(
 
thats not as bad as imagining a holiday on a hospital bed while your stomach eats itself :)
 
Mr Blonde said:
^
Otherwise, you could try using a H2 specific antagonist, like Zantac (ranitidine), which are less expensive but also less effective.
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Yeah I take Zantac, but after the CWE mix has absorbed. Just incase it interferes with the codeine to morphine conversion thing. But in the meantime i'm dumping acidic ibuprofen and acidic codeine phosphate into my stomach, so I had hoped the antacid neutralises the liquid. I've put a pinch of bicarb soda into CWE & noticed a fiz, so it's definitely acidic,, but then again so is a can of coke, and that doesn't hurt people.

The other person who was talking about danger of paracetamol and alcohol and the liver. Yeah I've read about that. Apparently when the liver is taking care of alcohol, paracetamol even at recommended dosage is harmful to the liver, But if you take the paracetamol first, then take the alcohol, there's not a problem. It's why I leave at least an hour until I drink alcohol after CWE, I figure the liver has done processing the paracetamol by then.

Here is a story about liver failure when taking recommended dose of paracetamol with alcohol already in the system

http://www.thehealthierlife.co.uk/n...-urinary/liver-failure-paracetamol-00237.html

EDIT: actually just read that.. it's a simulated scenario. not a real story.
 
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Ranitidine (Zantac) does inhibit the CYP2D6 enzyme [1]. A better option may be to use antacids, which by lowering the pH of the stomach [2] can help to increase absorption [3] since codeine is a basic drug with a pKa of 8.2 [4].

Researching for this post I found a cool link: Determine drug absorption by pKa. At the stomach's normal pH, codeine is completely ionized and not easily absorbed. By taking an antacid, you can raise the pH to 6 or 7 http://biology.clc.uc.edu/courses/bio115/protocols/pepsin.pdf"[2, at which up to 5.9% of codeine will be non-ionized and therefore lipid soluble and able to cross cell membranes. Once it reaches the blood plasma it becomes further non-ionized (~11.1% ), from where it reaches the liver and is metabolized into morphine.

[1] Martínez C, Albet C, Agúndez JA, Herrero E, Carrillo JA, Márquez M, Benítez J, Ortiz JA,
Comparative in vitro and in vivo inhibition of cytochrome P450 CYP1A2, CYP2D6, and CYP3A by H2-receptor antagonists.
Department of Pharmacology, Medical School, University of Extremadura, Badajoz, Spain.

[2] J. L. Stein Carter,
Pepsin Digestion Of Proteins And Effects Of Antacids
University Of Cincinnati

[3] allapharmacology

[4] Mark Earll
A guide to Log P and pKa measurements and their use
Mark Earll's Analytical Chemistry Site

Wow, referencing is hard work. ;)
 
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rofl:D

i actually had to fix ref #2 not 5, don't know where i pulled a 5 from. it was an effort and a half.

keep the noise down in there;)
 
Mr Blonde said:
Ranitidine (Zantac) does inhibit the CYP2D6 enzyme [1]. A better option may be to use antacids, which by lowering the pH of the stomach [2] can help to increase absorption [3] since codeine is a basic drug with a pKa of 8.2 [4].

Researching for this post I found a cool link: Determine drug absorption by pKa. At the stomach's normal pH, codeine is completely ionized and not easily absorbed. By taking an antacid, you can raise the pH to 6 or 7 http://biology.clc.uc.edu/courses/bio115/protocols/pepsin.pdf"[2, at which up to 5.9% of codeine will be non-ionized and therefore lipid soluble and able to cross cell membranes. Once it reaches the blood plasma it becomes further non-ionized (~11.1% ), from where it reaches the liver and is metabolized into morphine.

[1] Martínez C, Albet C, Agúndez JA, Herrero E, Carrillo JA, Márquez M, Benítez J, Ortiz JA,
Comparative in vitro and in vivo inhibition of cytochrome P450 CYP1A2, CYP2D6, and CYP3A by H2-receptor antagonists.
Department of Pharmacology, Medical School, University of Extremadura, Badajoz, Spain.

[2] J. L. Stein Carter,
Pepsin Digestion Of Proteins And Effects Of Antacids
University Of Cincinnati

[3] allapharmacology

[4] Mark Earll
A guide to Log P and pKa measurements and their use
Mark Earll's Analytical Chemistry Site

Wow, referencing is hard work. ;)
Click to expand...

Interesting about the codeine pH. A little after starting this thread I took some panadeine extra (500mg paracetamol, 15mg codeine) only took two tablets, and the same amount the next night. Anyway, it quite badly aggrevated the ulcer. do you think this was the codeine? I was under the impression that neither codeine nor paracetamol were bad for it.

Anyway, I have significantly cut back on coffee (one cup in the morning, maybe a 2nd cup at lunch) and most smoke 3 cigarettes a day (will cut down from there). It is actually feeling alot better. the cigarettes seem to be the thing that makes the biggest difference actually.
 
^ Neither paracetamol nor codeine should aggravate the ulcer. A google search for information about binders and fillers aggravating ulcers turned up a Google Books result that seemed interesting; a handbook on pharmaceutical tablet making, but I can't access the part of the text that was about which ingredients aggravate ulcers.
 
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