Limpet_Chicken
Bluelighter
- Joined
- Oct 13, 2005
- Messages
- 6,323
I have been looking into psychoactive Amanita species recently, and want to know more about two compounds found therein in particular, stizolobic acid , and stizolobinic acid, but, seemingly excitatory amnino acid compounds.
The few references I can find suggest that they are competitive antagonists at the AMPA receptor in crayfish, and kainate receptor antagonists in frogs, but last time I checked, I am neither.
http://grande.nal.usda.gov/ibids/index.php?mode2=detail&origin=ibids_references&therow=230866
This seems to suggest, given wikipedias data on kynurenate, which I know little about (yet) seems to suggest that these might be antagonists at the glycine binding site on NMDA, and probably also a convulsant excitotoxin at high doses.
Care to discuss, or shed more light on this one people?
4-(2-amino-2-carboxy-ethyl)-6-oxo-pyran-2-carboxylic acid structure of stizolobic acid (I am unable to find the structure for stizolobinic acid)
Seemingly present in certain varieties of A.Muscaria at low, low levels, and at higher quantities by far in A.Pantherina, which might explain why that one has a reputation for higher toxicity, including memory problems for a while post use?
The few references I can find suggest that they are competitive antagonists at the AMPA receptor in crayfish, and kainate receptor antagonists in frogs, but last time I checked, I am neither.
http://grande.nal.usda.gov/ibids/index.php?mode2=detail&origin=ibids_references&therow=230866
This seems to suggest, given wikipedias data on kynurenate, which I know little about (yet) seems to suggest that these might be antagonists at the glycine binding site on NMDA, and probably also a convulsant excitotoxin at high doses.
Care to discuss, or shed more light on this one people?
4-(2-amino-2-carboxy-ethyl)-6-oxo-pyran-2-carboxylic acid structure of stizolobic acid (I am unable to find the structure for stizolobinic acid)
Seemingly present in certain varieties of A.Muscaria at low, low levels, and at higher quantities by far in A.Pantherina, which might explain why that one has a reputation for higher toxicity, including memory problems for a while post use?