ebola?
Bluelight Crew
stimulant potentiation via deprenyl (selegeline)
First off, I want to consider this hypothetically, as I'm pretty sure that these combos are dangerous.
My layperson speculation about what's going on:
At doses where deprenyl is entirely selective for MAOB, you first might have direct potentiation, as MAOB is responsible for the metabolism of phenethylamine derived drugs. Second, you would have increased effective dopaminergic release, as MAOB is prevented from catabolizing dopamine. Depending on the time-course of MAOB's action, you'd have potentiation of immediate stimulant effects and/or increased duration. Anyone know which of these we'd expect? Third, you'd have reduced neurotoxicity, as deprenyl would prevent MAOB from catabolizing dopamine, which would release various free-radicals. Finally, you'd have possibly dangerous increased temperature, pulse, and BP when deprenyl prevents the breakdown of dopamine in the non-brain body. This effect could exacerbate neurotoxicity.
ebola
First off, I want to consider this hypothetically, as I'm pretty sure that these combos are dangerous.
My layperson speculation about what's going on:
At doses where deprenyl is entirely selective for MAOB, you first might have direct potentiation, as MAOB is responsible for the metabolism of phenethylamine derived drugs. Second, you would have increased effective dopaminergic release, as MAOB is prevented from catabolizing dopamine. Depending on the time-course of MAOB's action, you'd have potentiation of immediate stimulant effects and/or increased duration. Anyone know which of these we'd expect? Third, you'd have reduced neurotoxicity, as deprenyl would prevent MAOB from catabolizing dopamine, which would release various free-radicals. Finally, you'd have possibly dangerous increased temperature, pulse, and BP when deprenyl prevents the breakdown of dopamine in the non-brain body. This effect could exacerbate neurotoxicity.
ebola
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