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Stimulants of the Future

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stinky stim of the future

I haven't seen anyone using sulfur as an isoster in compounds related to cathinone. No doubt producing some stinky, low potency, possible stimulants. Single reaction should be able to replace the oxygen with the sulfur.
 
Survival0200 said:
How many years of organic chemistry do you have to read to be able to follow up and understand all the things in this topic? :\
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2 semesters of O-chem and 1 of cell biology for me, plus abundant time studying on my own.
I don't follow every bit, but I get enough out of it to know everything they are talking about, to some extent
 
^^ Survival
I've never been to an o-chem or bio class in my life.. Most of this thread isn't o-chem anyway, it's psychopharmacology, structural/receptor geometry, neurobiology, and SARs.
 
Finding this thread will either be the most rewarding or frustrating experience I have had in years, only time will tell. I have spent a major portion of my life (yes I know I should get out more) trying to find a quality "legal" speed. I have tried a lot of the chems mentioned here, including some of the rarer ones like 2diphenymethylpiperadine, and some even rarer like 4-phenylpiracetam (should have soon). My knowledge is all empirical/practical, I have no chemistry to speak of. I would be happy to share my experiences, sourcing etc with you to have your input and ideas.

From a users point of view (this one anyway) some pns activity is good, it's how some among us measure onset. A "clean" cns only stimulant like 2-dpmp can be a little like masturbating with a local anaesthetic, lots of action, going forever, but not "feeling" a lot! I'm not saying making your own toothpaste from the inside (the dreaded tooth grit) or wearing a hole in the carpet from an uncontrollable leg tremors is a good thing, just a happy medium would be nice.

Is it ok to leave a message for someone who has left some juicy info?
 
Survival0200 said:
How many years of organic chemistry do you have to read to be able to follow up and understand all the things in this topic? :\
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2 Years - Organic chem I and II ;)
 
^ =D

I was wondering, what do you think about the future of ADD drugs? Will all companies go the Strattera-way just to satisfy the drughaters? Or will a company actually get a new stimulant out there that's better (in one or more ways) than the current ones? Will any companies dust off some old compounds with less side effects than ritalin/speed? Or will they just keep cashing in on the workhorses?

Tweak more...get more done.
 
That's a good question. There are plenty of compounds in the literature with improved properties compared to methylphenidate. But I guess it's really hard to bring any stimulant compound with the slightest abuse potential to the market. Methylphenidate is a really crappy drug (short half-life etc) but is still the principal compound for the treatmanet of ADHD.

I think the underground market is more likely to come up with something new/old recycled.
 
^how's about a mothball your way with a naphthyl pyrrollidin deriv aka 1-naphthalen-2-yl-pyrrollidin-1-yl-pentan-1-one?

seems fairly epic as in nanomolar DAT / SERT / NET efficacy? although the SERT activity may make it less suited for the, ahem, ADD. now what were we talking about? ooh, look, a possum!
 
^Have u even tried stuff like MDPV? It's a pure reuptake inhibitor and thus feels very different from amphetamines, which are releasers. I havent heard of any DA agonists being abused. The tetralin scaffold provides a wealth of such compounds. Compounds like apomorphine induce vomiting but I think the D1/D2 ratio may be a factor.
 
^no comment, but subjectively some say the pyrovalerones blow doors off amps. the MDPV has almost nil SERT effects...
 
nanobrain said:
^how's about a mothball your way with a naphthyl pyrrollidin deriv aka 1-naphthalen-2-yl-pyrrollidin-1-yl-pentan-1-one?

seems fairly epic as in nanomolar DAT / SERT / NET efficacy? although the SERT activity may make it less suited for the, ahem, ADD. now what were we talking about? ooh, look, a possum!
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Yeah, low SERT activity will also increase the abuse potential compared with ones working purely on catecholamine transmitter systems. Not good for an ADHD medication


no comment, but subjectively some say the pyrovalerones blow doors off amps. the MDPV has almost nil SERT effects...
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In a paper about the pyrovalerones I read, the 3,4-dichloro compounds seem to be the substiutution pattern for maximum activity. Don't know if that'll confer neurotoxicity though and something a few times the potency of MDPV is frightening to think about - I've just been told of a xxxxxx (insert own insult/expletive) who dumped half a gram of MDPV into a glass of beer and drank it all! Then complained of not sleeping for days - god save us from such things...
 
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Any more on these?

The last two are very simple compounds that are esters of pseudotropine. The benzoate ester is also known as tropacocaine and has a potency of about 0.1x that of cocaine. replacing benzoic acid with 4-fluorobenzoic acid gives a compound of aprox 0.4x the potency of cocaine; considering how easy it is to synth (and not from monitored reagents - you can actually start from atropine and get to 3-pseudotropyl 4-fluorobenzoate in a few easy steps), I'm really surprised that it hasn't shown up in street cocaine. Maybe the market is so saturated that no one thinks it's economically viable[/QUOTE]

Are you saying these would/should have the same cns and pns package as cocaine?

Has anyone heard/seen anything further on these?
 
C6H6 said:
I'm surprised nobody mentioned amfonelic acid yet. It's a well documented, potent stimulant. One publication even concludes that it's more addictive than morphine.
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Anybody tried this one? It's available on line, if you don't mind the "hand over your car keys" price tag.
 
^^Reread the thread, someone mentions an assay. Until they work on the potency issue or pharmaceutically mass produce it, I don't think it'll be available to laymen like me.
 
fastandbulbous said:
Rather than go for 2-benzylpiperidine, the logical target should be 3-benzylmorpholine as of the the diphenylmethyl substituted heterocyclic compounds, the original paper reported the morpholine derivative to be by far the most potent locomotor stimulant in trials.

This has the extra advantage of being a few easy staps from phenylalanine (via phenylalaninol) rather than having to fuck around with expensive things like pipecolic acid & nast organometallic compounds (Grignard or organolithium)

BTW 3-benzylmorpholine has the same phenethylamine skeleton as 2-benzylpiperidine, it's just the numbering starts from a different place due to the heterocyclic oxygen atom
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Could you point me to these trials please?
 
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