• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio | someguyontheinternet

Stimulants of the Future

Status
Not open for further replies.
8)

Re: piperazines...i used to work for a "party pills" company in NZ, we assessed 1-BZP, 3Cl-PP, 3-TFMPP, 4-MeOPP, 4-FPP, 3,4-MDBZP, 1-Bz-4-Me-P, 2-BZP...most of them do have moderate stimulant/hallucinogen effects and many of them were safe and effective enough that they made it to market, but i wouldn't exactly say any of the simple piperazine derivatives are gonna be the next big stimulant of the future...if any of them were actually really fun drugs then the NZ government wouldn't have let them stay on the market for so long!

Also all of these piperazine derivatives give you a headache on comedown and some of them cause pretty severe nausea and vomiting in susceptible individuals, plus the ones with hallucinogenic effect feel mainly weird and creepy rather than an enjoyable trippy feeling. Thats the main reason that the NZ government has allowed them to remain legal so far, because the negative side effects are so prominant that at large or frequent doses you just mainly feel like crap, hence the abuse potential tends to be rather low...
 
^Piperazines are less desirable than the common stimulants available today such as:
cocaine
amphetamine
methamphetamine
methylphenidate
MDMA, rarely MDA
caffeine

Therefore, if they do hang in there and remain available until the future comes, it will be in spite of the fact that they are less desirable than the ones we often use today, not because of it.

Has anyone tried (d)-Bz-2-Piperidine HCl yet and known it?
I have. It is better than my previous two favorites, MDMA and meth.

Please refrain from personal flames or any other comment regarding the validity of my recent experience (the details of which you know nothing of) both unless and until you have repeated stated experience. I did less than a gram; stayed up for 4 to 5 days. Marked pupil dilation throughout. Tastes similar to ice but more minty. Looked like high quality powdered coke. Calmer and less jittery, paranoid and tweaky than meth but lasts just as long. Did two medium sized lines once and things started to get freaky; I was talking out loud nonstop in rhymes off the tip of my tongue from the depths of my soul without following a mould to see where this state of being would lead I could go on I guess ad infinitum but you shoulda by now have gotten the point assuming you read even the last few lines of this joint.
 
Last edited:
mad_scientist said:
8)

Re: piperazines...i used to work for a "party pills" company in NZ, we assessed 1-BZP, 3Cl-PP, 3-TFMPP, 4-MeOPP, 4-FPP, 3,4-MDBZP, 1-Bz-4-Me-P, 2-BZP...most of them do have moderate stimulant/hallucinogen effects and many of them were safe and effective enough that they made it to market, but i wouldn't exactly say any of the simple piperazine derivatives are gonna be the next big stimulant of the future...if any of them were actually really fun drugs then the NZ government wouldn't have let them stay on the market for so long!

Also all of these piperazine derivatives give you a headache on comedown and some of them cause pretty severe nausea and vomiting in susceptible individuals, plus the ones with hallucinogenic effect feel mainly weird and creepy rather than an enjoyable trippy feeling. Thats the main reason that the NZ government has allowed them to remain legal so far, because the negative side effects are so prominant that at large or frequent doses you just mainly feel like crap, hence the abuse potential tends to be rather low...
Click to expand...

Never got to try bzp but i heard it was a hard comedown.

cpp has the ability to cause nausea in some people even at a low 40 mg dose, while others can happily take 120 mg and feel no sickness, but it's always the same people so i guess its a sensitivity thing.

meopp is a pussycat, never had anyone complain of nausea right up to 300 mg and no comedown that i've ever heard of.

pfpp is one of those chems you take and 15 minutes later you can "taste" it, hard to define, it just "feels" dirty. no nausea but feel a bit grubby the following day.

never tried the others, variations on the theme i had been told by a long time kiwi seller.

they are a lot stronger and certainly longer lasting than a lot of the stuff around, especially when you read a couple of eu reports on confiscated pills around 20+ countries in europe. i guess buying pharms straight from the factory can spoli you.

seeing as how they have a 'zine now that is supposedly 100+ times stronger them morph with the same effect, the question was is this family capable of being tweaked to produce whatever you want?

is it just that so far "back room" engineers have'nt started playing with them?

maybe its a short history with most of the experience and commercialisation in the southern hemisphere?
 
Helios. said:
^Piperazines are less desirable than the common stimulants available today such as:
cocaine
amphetamine
methamphetamine
methylphenidate
MDMA, rarely MDA
caffeine

Therefore, if they do hang in there and remain available until the future comes, it will be in spite of the fact that they are less desirable than the ones we often use today, not because of it.

Has anyone tried (d)-Bz-2-Piperidine HCl yet and known it?
I have. It is better than my previous two favorites, MDMA and meth.

Please refrain from personal flames or any other comment regarding the validity of my recent experience (the details of which you know nothing of) both unless and until you have repeated stated experience. I did less than a gram; stayed up for 4 to 5 days. Marked pupil dilation throughout. Tastes similar to ice but more minty. Looked like high quality powdered coke. Calmer and less jittery, paranoid and tweaky than meth but lasts just as long. Did two medium sized lines once and things started to get freaky; I was talking out loud nonstop in rhymes off the tip of my tongue from the depths of my soul without following a mould to see where this state of being would lead I could go on I guess ad infinitum but you shoulda by now have gotten the point assuming you read even the last few lines of this joint.
Click to expand...

certianly agree on most you got there, its that leagal angle that spoils a good day. ritalin has always felt a tease to me, it feels like your on the way but you never seem to make it. you must be able too get hell coffee where you are! just kidding, caffeine has always given me more cramps than amps.

really interested in your chem there, any names, places? on site os your call :)
 
Speaking of that article, why does nocaine have the opposite stereochemistry from cocaine at the 3 position? I thought 3beta, 4beta would have conferred the most potency.
 
It was argued that the 3-alpha stereochem makes the compound less addictive. You can find alot of the discussion if you run a search on JPET.

However an interesting document that I want to show you is shown here: %)
 
Last edited:
Smyth said:
It was argued that the 3-alpha stereochem makes the compound less addictive. You can find alot of the discussion if you run a search on JPET.

However an interesting document that I want to show you is shown here: %)
Click to expand...

thanks for the info. i remember some saying tropane synths were not for the faint hearted? as i'm not capable, i use a couple of small companies in china to turn dreams into reality and they are a gen or so behind, confidence wise if not in technique, and often won't attempt anything tricky, or reported to be so.

that's why i hoped someone well schooled could give me an honest opinion as to which coc analog(s) were the best combination of potency with a not-too-frightening synthesis :)
 
I'm going to try not to tresspass here, but one word "Mannich".

everhopeful said:
thanks for the info. i remember some saying tropane synths were not for the faint hearted? as i'm not capable, i use a couple of small companies in china to turn dreams into reality and they are a gen or so behind, confidence wise if not in technique, and often won't attempt anything tricky, or reported to be so.

that's why i hoped someone well schooled could give me an honest opinion as to which coc analog(s) were the best combination of potency with a not-too-frightening synthesis :)
Click to expand...
 
It's easy to split off only one of the 2 methoxycarbonyl groups thermally. So this is a very viable route.
 
^
Wow, you guys sound like scientists. I think that amphetamines have potential to become more potent and last much longer. I don't know how much longer you want them to last though, i couldn't imagine a high lasting more than 48 hours. It would also be cool to see something neat happen to weed. Like if they combined weed with some really cool plant that completley altered the effects. Im sure they already have just haven't mass produced the idea yet.
 
^ Haha, same here. I wonder how I will tackle hierarchy and the intrigues, that come in both the academic world and the commercial world, when I have graduated. I've got the impression the big corporate world attract many careerists who mind their wallets and prestige more than their fellow humans. And the academic world also seems somewhat deranged.

All I want is a playground (i.e. lab) and not too much stress. I wonder if that equation will be solvable. :\ ;)
 
Last edited:
Moderators: Delete this post if it crosses the line.

everhopeful said:
cheers i'm on it. i'll let you know what turns up/out. thanks again :D
Click to expand...

Also, altering the reaction temperature alters the isomeric composition of the final product, so using dry ice to cool the reaction will give a different product than just using ice water. If you do some searches in article databases there are a few articles that discuss these analogs and contain activity measurments of both structural and stereo isomers.
 
Status
Not open for further replies.
Top