Stimulants of the Future II

[c0rt3x]

^^^You are playing with fire.

Rather researching than playing. ;-)

But yes, I know those kinds of Self-experimentation are always a risk. But as you know: "Now risk - now fun!". Keep in mind that not even Shulgin himself - who knows incredibly much about chemistry and pharmacology could be absolutely sure about the safety of his inventions...

no synthesis discussion! - nuke

But just in case you asked that question because you intended to warn me again because it is toxic - then think about the fact that kmno4 LD50 is 1090 mg/kg (rat (oral)

 

[vecktor]

Rather researching than playing. ;-)

But yes, I know those kinds of Self-experimentation are always a risk. But as you know: "Now risk - now fun!". Keep in mind that not even Shulgin himself - who knows incredibly much about chemistry and pharmacology could be absolutely sure about the safety of his inventions...



no synthesis discussion! - nuke

the LD50 of KMnO4 is irrellevant. the problem is more that ingestion of even small amounts of high valent manganese causes severe brain damage.
so I suggest _you_ think about that.

 

[indelibleface]

http://en.wikipedia.org/wiki/Ethyltrifluoromethylaminoindane

Just found this on Wikipedia. Any potential? Is this old news?

 

[Hammilton]

Not exactly, but it should have even less potential than MDMAI and Fenfluramine, so very little.

 

[/navarone/]

GOT IT!!
The easy to make low-cost non-neurotoxic fast-acting stimulant product of the future.
A potent substance that will make you run for miles without the slightest concern of it's effort.
Eyes as wide as a sattelite dish and Muscles so alert that siren lights will come out ur ears.
A rush of adrenaline that will invade your body like US Army troops.
Never in your life will you feel so fucking alive!

Gentlemen, i bring to you:

- The Capsaicin Suppository -

 

[/navarone/]

K... pardon me for the post above people.
Just felt like throwing in something stupid XD

Anyway for those who have not come across this page, i suggest to have a look at these.
They're two Wikipedia articles listing many and i mean many different sustituted amphetamines and metilendioxyphenyethylamines.

http://en.wikipedia.org/wiki/Substituted_Methylenedioxyphenethylamine
http://en.wikipedia.org/wiki/Substituted_Amphetamine

A few seem rather interesting from the description...
Many of them are more entactogen rather than stimulants...but still t's worth a look

 

[DMTime_warp]

Iv'e got one, it's based off nyphyrone/Napthylaminopropane and phenmetrazine.

3-ethyl-2-(naphthalen-2-yl)morpholine

 

[boohigh]

green cows again, eh?
What stand besides this picture - have you done some research and forget to include it in your post? Or maybe some middle-east gay community are baking it now and abusing the shit out of it?
What's your point?

 

[nuke]

I'm not touching anything of these naphthyl compounds until I've seen some long term toxicology data.

 

[Hammilton]

I'd be careful about them too, especially any with a tertiary nitrogen a la mdpv (Halfpenny, P.R.; Horwell, D.C.; Hughes, J.; Humblet, C.;Hunter, J.C.; Neuhaus, D.; Rees, D.C. J. Med.Chem., 1991,34, 190.)

 

[DMTime_warp]

Probably a good idea since the napthyl compoudns are rather new, what about oxazolidine compounds, im searching for info on 4-methyl-5-phenyl-1,3-oxazolidine at the moment, haven't come across any good documentation yet but the structure is similar to pemoline/4mar that could mean it is possibly hepatoxic and potentially neurotoxic though.

 

[Hammilton]

The difference between a naphthyl mdpv and the kappa agonists in that paper isn't that great. At least I don't think so. I don't have the paper with me right now.

 

[DMTime_warp]

Napthylaminopropane, apparently is under investigation for the treatment of alcohol and stimulant addiction. It is apparently a non-neurotoxic triple releasing agent(dopamine, serotonin, norepinephrine) which brings me back to a subject on a thread about MDAI in which people were trying to figure out if combining a DRA would make MDAI(SSRA) neurotoxic. My only real concern is if this compound forms a carcinogenic napthylene epoxide, although i beleive with the beta-blocker Pronethalol it is due to the beta hydroxy during metabolizing process. I'm not so sure I like the fact that it has an affinity for the 5HT2c receptor. Back when I was taking amphetamine I became really malnourished due to it's anorectic effects.

http://en.wikipedia.org/wiki/Naphthylaminopropane

 

[Rectify]

4-ethylmethcathinone might be rewarding much like 2ce vs 2cd.

 

[Hammilton]

Yeah, but the 2C reference is completely irrelevant. Without a dimethoxy group it won't have any 5HT2a affinity (or at least no relevant affinity given the stimulant potency) so there's obviously no way to extrapolate from those two substances to methcathinone derivatives.

 

[innerfinnisher]

Since "chloral hydrate" posted another methylphenidate like compound please think again about my "(Methyl-)Amphenidate" idea:

The idea behind it was the following:

Since Methylamphetamine is primary a dopamine releaser and Methylphenidate a dopamine reuptake inhibitor I thought why not try to combine both mode of actions together in a single molecule? I think it was at least worth a try.

@Hammilton: Although I really value your knowledge - I have to please you not to get impolite again only because you disagree with a idea or the fact that someone can't explain the pharmacological background of a thought as well as you. Thanks.

This is a sage combination from a pharmacodynamic perspective. It may be counter intuitive to some but studies have already published detectable biochemical alterations that would readily be beneficial to the CNS.

 

[hamhurricane]

^^^
are both those nitrogens necessary? i would leave out the second one, as it is not present in MPH or AMP and make it look like pheniprazine or some other hydrazine antidepressant - which are often hapatotoxic, and obviously potent MAOIs...not sure if those effects would be retained with the beta-sub but why risk it?

 

[/navarone/]

A little question...
Is amphetamine-like DAT inhibition selective? or does it increase dopamine levels throughout all the dopamine system?
I'm asking this because general stimulants normally tend to give nasty psychological side effects, one of the nastiest is psychosis which i find it unbearable. I'm not really sure which dopamine receptor is responsable for psychotic symptoms but a little voice tells me that it would be better if the drug was a selective agonist rather than a general DRI.

 

[TheAzo]

Has 4-Methyl-(meth?)amphetamine (ie, the amphetamine analog of mephedrone) been investigated as a recreational drug?

It seems unusual that the cathinone would be prepared without the amphetamine already being known (since all the other cathinones are imitations of much more fun amphetamines).

The substance is known, is neurotoxic in lab tests (but so is 4-chloro-amphetamine, but there are reports of it being used long term as an antidepressant), but was proposed as an appatite suppressant "Aptrol", but I wasn't able to find much info on it (web searches are complicated by the fact that it's an easy mispelling of "patrol").

I feel like someone, somewhere, must have tried to get high off of it.

 

[boohigh]

Yes, 4-methylamphetamine had a little poplularity in Moscow, two years ago, i have personally shoot it in doses from 50 to 100 mgs. Effects was mdma-like with CEV and calm stupefying euphoria. Also tried this intranasally in small 5-15 mg doses - worked quite well for listening a concert. There was number of scary reports with people founding themselves day after without a wear, fully amnesiac from using it with alcohol. also it was prone to gave prolonged depression afgter use with suicidal thought to people who are generally very antisuicidal. It was a scary stuff.