Don't take much stimulants, but I've noticed when I do MPA different kinds of Opiates don't seem to have much effect the next day and a for a few days after (or taken in the same day). I'm a bit confused as I've seen people say Speed or Meth heighten the Opiate high but it seems to reduce it for me. Any similar experiences or explanations for this?
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OD Moderators: Keif’ Richards | negrogesic
Stimulants Stimulants block Opiates?
- Thread starter Ninae
- Start date
THE_REAL_OBLIVION
Bluelight Crew
MPA is what ? If you meant MPH, maybe so.
I know that binging on Dexedrine and IV'ing dilaudid here and there when I'd get too nervous was godly.
I know that binging on Dexedrine and IV'ing dilaudid here and there when I'd get too nervous was godly.
Tryptamino
Bluelight Crew
^MPA = Methiopropamine
Stimulants and opiates taken orally or nasally can seem to overpower each other if the dose is not balanced correctly. Also the specific kind of stimulant/opiate plays a part in whether they will synergize or cross-cancel.
Stimulants and opiates taken orally or nasally can seem to overpower each other if the dose is not balanced correctly. Also the specific kind of stimulant/opiate plays a part in whether they will synergize or cross-cancel.
I've mostly tried it with UEI (strongest Kratom extract) which usually is very powerful.
On another note, MPA is VERY bad for you, though, and will no doubt be known for it. I can just feel it affecting my body in so many bad ways it must be doing some serious damage. This is what I dislike about stimulants as opposed to downers like beenzos and opiates that just senf you asleep.
On another note, MPA is VERY bad for you, though, and will no doubt be known for it. I can just feel it affecting my body in so many bad ways it must be doing some serious damage. This is what I dislike about stimulants as opposed to downers like beenzos and opiates that just senf you asleep.
Znegative
Bluelight Crew
It depends on the stimulant, but no stim can actually "block" opiates (unless they also antagonized the opiate receptors as well), they can just overpower the opiate effects.
BlueHues
Bluelighter
I agree. That's one of the reasons I believe it can be dangerous to mix stimulants and opiates. It can seems like the two drugs are cancelling each other out and it can cause you to constantly re-dose one or the other in an attempt to feel high. The stimulants can actually prevent an opiate overdose, temporarily. But when the stimulants wear off, wham!
It's all about finding the right combination.
alprazolam and adderall seem to cancel each other out completely, IME. A waste to try and combine those two drugs. but that's another story altogether. Most of the time, I think you're better off just waiting until you're crashing off the stimulants to use whatever "downer" you happen to have.
Actually, I take that question back. I can remember using just MPA for days before opiates before and they worked great, like with no tolerance. I now think the effect is due to using Loperamide for days, causing some kind of huge opiate tolerance.
This is because a couple of months ago I took Loperamide after feeling a bit shitty after a week of Kratom use. I took between 100-150 mgs for 5-6 days and it worked great. Not that I was very high, but definitely above baseline and feeling pretty good, much better than from benzos anyway. But this time I felt nothing, or practically, just really boring. Even being able to dose on UEI at the same time didn't heighten the effects. Or, I'm sure if I was addicted I would manage to avoid that desperate feeling or any real withdrawal, but as I'm not and only use it occasionally I don't need it that way so it was just a waste of time.
Unless you were desperately in need of an anti-depressant for some reason, then I think it would help bring you closer to normal, but I'm just not going to touch any opiates for a while after dosing like that on Loperamide. So I guess it was just high opiate tolerance instead. As you say, stimulants are shortlived and shouldn't affect it that much. Though they do cancel out benzos when taken too much (while taking just a little with mainly benzos can be really good).
This is because a couple of months ago I took Loperamide after feeling a bit shitty after a week of Kratom use. I took between 100-150 mgs for 5-6 days and it worked great. Not that I was very high, but definitely above baseline and feeling pretty good, much better than from benzos anyway. But this time I felt nothing, or practically, just really boring. Even being able to dose on UEI at the same time didn't heighten the effects. Or, I'm sure if I was addicted I would manage to avoid that desperate feeling or any real withdrawal, but as I'm not and only use it occasionally I don't need it that way so it was just a waste of time.
Unless you were desperately in need of an anti-depressant for some reason, then I think it would help bring you closer to normal, but I'm just not going to touch any opiates for a while after dosing like that on Loperamide. So I guess it was just high opiate tolerance instead. As you say, stimulants are shortlived and shouldn't affect it that much. Though they do cancel out benzos when taken too much (while taking just a little with mainly benzos can be really good).
Jabberwocky
Frumious Bandersnatch
I don't have too much experience with stims compared to opiates, but i do know that stims basically "block" opiates' subjective effects for me. I remember a time, during my heavy oxy usage (long-term, high / daily usage w/o interruption) that i partied with someone who was heavily into stims, and i did the 'when in rome' approach with them lol. I remember going home, like 2d after starting that party, and out of nowhere realizing that i hadn't taken any oxy in *days* (I was using 150mg+ daily long-term / rx'd). I took a couple b4 crashing into my bed, but it wasn't even out of a desire/craving, it was to help ensure i wouldn't wake up in ridiculous withdrawals. In the ~hr that it took me just to get my ass into bed (yay for amph psychosis 
), i never even noticed the 60mg oxy that was my 1st dosage in days.
full subjective blocking of opiates on high-dose amp for me.
), i never even noticed the 60mg oxy that was my 1st dosage in days.full subjective blocking of opiates on high-dose amp for me.
amphetamines release vast quantities of biogenic amines such as dopamine, NE, and sert in addition to the other effects it has such as binding to DAT. however, like amps, opiates also increase extracellular levels of dopamine and sert. despite both drugs leading same result, they have different mechanisms of actions explaining why they release these monoamines.
when taken together (amps and opiates) the spontaneous release of dopamine and sert from each drug synchronizes to exponentially increase extracellular dopamine levels caused by each drug. in other words 1+1=3
so in theory if one wants to combine amphetamines and opiates, taking less of each is advised to get optmial results. for example, if you usually took 50mgs addy alone to get high, or 50mg oxycodone by itself to get high, you would cut each dose in half when combined such that instead of 50 and 50, you take 25mg addy and 25mg oxycodone
although amps decrease sedation caused by opiates, they definitely increase the euphoria in theory. for myself, i LOVE LOVE LOVE LOVE taking hydrocodone or suboxone with amphetamines, the feeling is fucking awesome! however because oxycodone makes me stimulated enough, i feel like it doesnt synergize well, like i just feel high on oxy and high on amps, not feeling super high from being on both.
when taken together (amps and opiates) the spontaneous release of dopamine and sert from each drug synchronizes to exponentially increase extracellular dopamine levels caused by each drug. in other words 1+1=3
so in theory if one wants to combine amphetamines and opiates, taking less of each is advised to get optmial results. for example, if you usually took 50mgs addy alone to get high, or 50mg oxycodone by itself to get high, you would cut each dose in half when combined such that instead of 50 and 50, you take 25mg addy and 25mg oxycodone
although amps decrease sedation caused by opiates, they definitely increase the euphoria in theory. for myself, i LOVE LOVE LOVE LOVE taking hydrocodone or suboxone with amphetamines, the feeling is fucking awesome! however because oxycodone makes me stimulated enough, i feel like it doesnt synergize well, like i just feel high on oxy and high on amps, not feeling super high from being on both.
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THE_REAL_OBLIVION
Bluelight Crew
I wonder what you guys are on, like I said, I would shoot Dilaudid everytime my body would start telling me I had gulped one too many Dexedrine and I felt godly good, and it was definitely a synergism between the 2 as it felt much much stronger than Dilaudid alone...oh well, everybody is different I guess.
Jabberwocky
Frumious Bandersnatch
^if you were taking oral dexedrine, perhaps you weren't sped enough? I dunno. In the experience i mentioned, we were doing heroic amp doses (smoked).
THE_REAL_OBLIVION
Bluelight Crew
When I binge on my scripted Dexedrine, I take around ~150mg in 3 days of 5mg IR pills and 10mg spansules...believe me it is very effective at spunning me the fuck out after just day 1.