N&PD Moderators: Skorpio
stimulant without vasoconstriction ??
Hello, please help me. I want a some stimulant (some from research chemicals), but without fuckin vasoconstriction. I read about mephedrone, methiopropamine, atd... but i read a lot reports about vasoconstriction for almost every designer drugs(dont tell me, the legal drugs causes this shit, and illegal not?It,s strange) but a dont want risk! Know you anyone some good stimulant without this vasocoshition ?thanks verymuch and sorry for my bad english
negrogesic
Bluelight Crew
Most stimulants with long-term or 'practical' abuse potential will inherently cause this, personally i found phenmetrazine to have 'less' subjective vasoconstriction than other powerful stimulants, with a relatively favourable side-effect profile, 'light' body load etc.....
Then again, i only used it perhaps a dozen times, this stuff is not easy to obtain...
In a good lab setup the synthesis of this compound is not that difficult, there are a number of ways to approach this, but if i need to elaborate you already know too little......and no, it is not super easy like a methamphetamine synthesis. PPA is a common route, but i'd personally save the PPA for a reunion with N-methyl-4-piperidone and Mel...........can't elaborate on either..........
Modafinil, though not 'rewarding', does not appear to cause especially unpleasant vasocontriction, but again, it is subjectively of very low recreational value....
If you want to play with 'rewarding' psychostimulants, there are almost always some sort of intrinsic 'risk'..........
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negrogesic
Bluelight Crew
well........exogenous dopamine is technically more 'potent' in both the release and uptake of NE than exogenous NE......
^Xayo
Bluelighter
the reason why alot of designer drugs are more vasocontriscting than illegal substances is because the illegal substances are somewhat the "ideal" stimulants while the RC's have to be modifications of the illegal stimulant to get around the laws. With more modifications from the original compound there come more side effects with less potency. Ofcourse this might not be always the case
...
Bluelighter
Thanks. I was thinking about clenbuterol (which is not however specifically used as an antidepressant), for its probable vasodilatative effects despite its similarity to epinephrine see:
http://en.wikipedia.org/wiki/Adrenergic_receptor
negrogesic
Bluelight Crew
Take caution with clenbuterol. Yes it is technically a psychoactive drug (having central activity; CNS stimulation), but is very rarely used as a CNS stimulant due to its laundry list of side-effects, toxicities, narrow therapeutic index etc.
Furthermore, this compound is highly potent, dosed in the micrograms, and under NO circumstances should one handle the pure compound in non-laboratory settings, without a full face respirator, etc, etc. I believe it is at least considered a PG-III - aka UN class 6.1(b) toxic compound - and inhalation of the powder is a recipe for a fatal AMI (acute "heart-attack"). Even with therapeutic doses patients can develop SAS (subaortic coarctation, or perhaps coarctation of the aorta itself), which basically translates into; cardiotoxicity - bad for your heart.
Clenbuterol has legitimate uses in medicine (and for most cases, better alternatives), and possess somewhat less legitimate uses as an ergogenic-performance enhance; however usage for the sole purpose of CNS stimulation is RARELY seen. CNS-stimulation is a side-effect of this drug, is of low/unpleasant quality, and is not safe for this purpose (nor desirable). As far as I know, it has no "anti-depressant" properties; in fact i'd go as far as to say that it likely has opposite effect.
Again, I don't really understand what you are trying to ask here, but once again, I'd have to recommend modafinil.
nope. anything that could be considered a sympathomimetic, or that somehow indirectly stimulates increased sympathetic output has the potential to cause vasoconstriction (there may be a few exceptions to that, but they won;t be interesting).
why are you so worried about vasoconstriction? if you already have some kind of vascular problem, stay away from stimulants!
if you have to, i second modafinil. it's effects are mostly on the brain, but stimulatory side effects are still possible.
