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  • BDD Moderators: Keif’ Richards

Stimulant come downs and DPH

Renz Envy

Bluelighter
Joined
Sep 29, 2010
Messages
3,337
Quick question since I see a small issue here. A lot of people recommend DPH(benadryl) for coming down off of a stimulant and getting sleep.

Would DPH cause enough vasoconstriction to perhaps increase the strain the stimulant is putting on the body?
 
DPH can cause increased heart rate. I'm not sure if this is due to vasoconstriction or not. I know its annoying trying to go to sleep and your heart is racing, not because of the stimulants anymore but because of the drug you took to come down off the stimulants. YMMV...I'd be interested to see others experiences with this, however.

IME, it really depends on when during the come down you take it. If you're still "up" on stimulants, DPH doesn't seem to do much. The only antihistamines that do are promethazine and to a letter extent doxylamine.
 
It'll help you come down and fall asleep a little, in the sense that trying to put out a house fire with an eyedropper helps.
 
Best come down for me when I'm coming off amphetamines is Lunesta which is the z-drug I'm prescribed for sleep. It works GREAT! Instantly switches you from ''upper to downer'' so to speak. Next best thing i'd say would be alcohol. take a shot or a couple beers before sleep and im out like a fat kid in dodgeball
 
Best come down for me when I'm coming off amphetamines is Lunesta which is the z-drug I'm prescribed for sleep. It works GREAT! Instantly switches you from ''upper to downer'' so to speak. Next best thing i'd say would be alcohol. take a shot or a couple beers before sleep and im out like a fat kid in dodgeball

Okay, but the likely reason he's asking about DPH is because he has no access to z-drugs and benzos.
 
Nah I had already eaten my entire script of Klonopin and felt only a slight relaxation.

The DPH did work. 75mg put me to bed in about 45 minutes. I'm one of those "Easy sleepers."

GHB is the best come down drug for amphetamines in my opinion.
 
I'm not sure if you're recommending GHB to others to use as a comedown drug, Renz, but if you are, it's far too addictive. I know your intentions are good, but there are other drugs that can work in a similar fashion to GHB without being as addictive, like Phenibut or Baclofen. However, the main benefit is that GHB causes dopamine antagonism, which is perfect for coming down off of stimulants, but that antagonism can be achieved with other drugs, not necessarily antipsychotics.

Thanks for giving us your experiences on DPH as a comedown drug, I will recommend it to others who have trouble sleeping after taking stims. I agree with NT, though, that the anticholinergenic effects of DPH could mess with your heart rate and dry you out, perhaps Hydroxyzine is a better choice for this, lacking significant anticholinergenic actions, and instead acting as a sedative through D2 (dopamine receptor) antagonism and antiserotonergic actions, like 5-HT2C antagonism.

I recommend every stimulant user taking 1mg melatonin at night. Not only is it an extremely powerful antioxidant, but it tells your body it's time to sleep by affecting the circadian rhythm, rather than just knocking you out like antihistamines. Doxylamine could be a better OTC sedative than DPH, though, as it has more powerful anticholinergenic actions, less Dopamine agonism that would tend to keep you awake, and it tends to produce less of a hangover, despite its beneficially longer half life.

Also, every stimulant user should take 300mg chelated Magnesium before bed on an empty stomach, and 150mg on an empty stomach before dosing amphetamines. Beware, though, Mg can make your pH levels more basic, potentiating amphetamines. I offset this pH change with the 250mg Vitamin C in a Super B Complex after breakfast. Zinc on a full stomach after dosing amps is another great immune booster and REM-sleep increaser, and potassium supplementation is also beneficial by reducing risk of stim-induced strokes.
 
I'm not sure if you're recommending GHB to others to use as a comedown drug, Renz, but if you are, it's far too addictive. I know your intentions are good, but there are other drugs that can work in a similar fashion to GHB without being as addictive, like Phenibut or Baclofen.

Haha! This reminds me of the time I used a RC meth analog to quit synthetic cannabinoids >.>
 
Diphenhydramine is also very 'confusing'. Any dose over 50mg I always get some taste of delirium, weird thoughts and sometimes hallucinations. I can see stims only adding to this.
 
For me, DPH is useless as a comedown aide. only something strong like cannabis concentrates, benzos, or the like will help. Antihistamines lose the sedating effect and just add to depression/physical fatigue and add an unwanted trippyness. thats me though...
 
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