Stepping up a level to ADD!

[tyrael]

Morning my fellow ADDers. Just thought I'd come in and say hi since you'll probably be seeing more of me around here - asking annoying beginner types questions, so bare with me!

After a slight hiatus from it all (use/culture/study/etc) I'm back with a vengeance! So in addition to my (imho ) rather solid, foundational understanding of chemistry and pharmacology, I have just began my (second degree) B.Hlth.Sci, majoring in Pharmacology. (may do a second major yet, haven't decided)

Please be patient since I'm sure (at least to begin with) I'll ask some pretty rudimentary (at least for you guys in ADD) questions.


Peace out!

 

[tyrael]

Actually, I do have a request - what I'm after is a reference listing functional groups and their attributes/properties yet from a pharmacological/medical point of view.

I understand a few, and I'm sure I could search/collate however preferably I would like one reference with them all!

 

[i are spectre]

there isnt a specific effect from a compound with say one of each functional group, physiologically anyway.

it depends on the structure. a lot form dimers with ligand gated channels, activating G proteins and other ion channels. there are many compounds that are structurally different yet offer near equal effects, and there are compounds that are merely identical and have very opposite effects.

there is no list of what a functional group does to a living system. it depends on the entire compound, it's stereochemistry, metabolic pathway, and conditions of the living system and/or environment.

 

[tyrael]

Hmm, ok. The reason I ask for example is that I know (generally?) an acetyl functional group allows a compound to cross the BBB easier. ??
Nothing like this?



Cheers for the reply on any account!

 

[atrollappears]

Basically anything that will even out the polarity of a molecule will allow it to cross the BBB better, i.e. the N-methyl on methamphetamine (which accounts for its effects because amphetamine is more potent in the brain).

(I think.)

 

[ebola?]

(which accounts for its effects because amphetamine is more potent in the brain).

(I think.)

D-methamphetamine has smaller ec50 values than d-amp for all 3 monoamines.

ebola

 

[atrollappears]

D-methamphetamine has smaller ec50 values than d-amp for all 3 monoamines.

ebola

http://www.biomedcentral.com/1471-2210/6/6/figure/F1

This graph shows, in terms of transport activity, that amphetamine is more potent than methamphetamine on NA, equipotent on hDAT/ever so slightly more potent on mDAT, and less potent on serotonin (which I'm still not convinced is relevant to either's therapeutic or recreational use in humans). But these are the racemates, and I admit EC release values tell a better story than IC transporter values.