Started a new drug combo (please indulge me)

[streetsurfer]

Still battling with depression/social phobia. I just ge no plesure out of life and I am thinking seriously of going back on the ritalin/selegiline combo I have warned everyone off cos it is the only thing that.

(1) made me feel not sad
(2) energised me)
(3) made me not feel lonely

Even though it desroyed my memory, my organisational ability and gave me some parkinsonian like symptoms like leaving parts of words unwrit lik thi.

My latest attempt is thus.

Morning

20mg sideffexor XR
2.5mg selegiline
70mg caffene as gurana plus ginseng
Asprin, paracetamol, caffine synergistic combo
25mg Lamictal
4000mg fish oil Potentiated with black strap mollasses (uridine)

Lunch

20mg sideffexor XR
2.5mg selegiline
70mg caffene as gurana plus ginseng
Asprin, paracetamol, caffine synergistic combo
Megamulti
Vit E
25mg lamictal
folic acid

My question is, how real is the potential of toxic drug interactions because I am of the opinion that all these contraindications are by and large drug company propaganda to try and stop of finding effective treatment so we keep buying the latest and greatest and expensive and again inneffecive treaments.

Thoughts?

 

[Smyth]

Selegiline is selective for MAOIB wheras Effexor is a substrate for MAOIA. Im surprised taking ritalin and selegiline didnt cause hypertension which can be dangerous.

Certainly if u took Effexor in conjunction with a MAOIA (or mixed) inhibitor u might get serotonin syndrome. Although moclobemide is meant to be a safer choice of RIMA.

I see your concern but if the combination you are taking truly is dangerous u might not be taking a high enough dosage for hazardous interaction to come into force.

 

[djfriendly]

Best of luck, man. I just wanted to say I was very amused at your re-naming of "sideffexor."

 

[deeperSense]

what is the dangers of mixing amphetamine,cocaine,ketamine,MDMA crystals &wots the likely long term damage from this combo???

 

[rashandreflex]

ok a few questions...first, what brand of fish oil are you taking? it's really best to have at least a 2:1 epa:dha ratio....but the higher the better if you're using it for mood stability. i take omega brite which is 7:1. second, the dose of lamictal and the dose of selegiline you have listed are pretty low...i hesitate to say 'sub therapeutic' bc everyone's body is different, but you have room to move those up, so why not do that before adding something that is potentially dangerous? most of the literature i have read has said MAOIs and stimulants are a big no-no....i understand where you are coming from in terms of drug company propaganda, but personally in the case of mixing selegiline and ritalin, i would err on the side of caution and exhaust all other possible routes bc hypertensive crisis isn't really the same as 'these two may make you drowsy' or something. what other medications have you tried? have you done therapy? what kind of social support do you have?

 

[streetsurfer]

Funnily enough I never once got a hypertensive reaction to the contrary I had several dangerously HYPOtensive reactions (try 60/40) .

I don't want to go higher with the venlafaxine cos it turns my bowels to stone and I am working up with the lamictal. Also Tardive dyskenisa is a concern with the effexor

 

[nanobrain]

Morning

20mg sideffexor XR
2.5mg selegiline
70mg caffene as gurana plus ginseng
Asprin, paracetamol, caffine synergistic combo
25mg Lamictal
4000mg fish oil Potentiated with black strap mollasses (uridine)

Lunch

20mg sideffexor XR
2.5mg selegiline
70mg caffene as gurana plus ginseng
Asprin, paracetamol, caffine synergistic combo
Megamulti
Vit E
25mg lamictal
folic acid

My question is, how real is the potential of toxic drug interactions because I am of the opinion that all these contraindications are by and large drug company propaganda to try and stop of finding effective treatment so we keep buying the latest and greatest and expensive and again inneffecive treaments.

Thoughts?

ahem. cough. that there last bit is borderin on nanothink, ol' son, which aint never a good thing, ie yes i am paranoid, but am i paranoid enough?

now as to your recipe. do you sleep? as in REM? how's them dreams? how's, cough, your sexual function?

paracetamol is extremely hepatotoxic, at doses much lower than the misknown amount. after some of me rats died (used as a comparator drug in a test) and i saw the morphology micros, i flushed my stash. btw, it is contraindicated w/everything.

and if you want to retain semblance of humanity, get weaned of the 'sideffexor' - but then y'all know my opinions in re this one.

oh, gurana is a dirty caffeine source, may i suggest a 2x short black 3x sugar? and 500mg l-phenyl instead of the UFOSRI, in retrospect.

PS, w/that mix i'd stay well clear of 5-HTP.

 

[streetsurfer]

Sleep and sex, Started overseleping again. The only thing that normalised my sleep was prozac and that when I was on it and a meth binge and fuck fest gave me priaprism and and damaged my cock which it is only just getting over now a year later (funnily enough with the resumption of a ssri.

Labido is better now, usually zero, still pretty low but I have been taking DHEA for a week or so now so maybe that has something to do with it?

I knew paracetamol was hepotoxic but not quite that bad, I shall be far more carefull. Gurana is a bit iffy, maybe I will drop that, I just find that the selegiline potentiates it nicely


REM, - Train myself to forget my dreams, traditionally that are of a hopeless, helpless, persacutery nature.

I fucking hate effexor, I have seen it make people quite preditory and I think it may bring out a nasty streak in me also but what else do I use? prozac and citalopram were the only others that worked. Prozac gave me severe tardive dyskinesa even at sub theraputic levels and citalopram worked ok for a few years 3 or 4 years back but then stopped.
Do you think 5-htp instead? Would D L Phenelenaline be better than the L isomer?

 

[Olos Dreamwalker]

God damn Effexor XR, I've been on it for 6 days and the nightmares never leave my mind...they are horribly realistic, graphic, and often disturbing. I have found myself on several occasions now believing myself to have had some sort of conversation or fight with a family member, to then ask them about it, and have them stare at me and say it never happened. Sucks. Really. Friggin. Sucks.

 

[daddysgone]

Someone suggested that you try increasing your dosage of selegiline.
I must STRONGLY disagree with that suggestion.

I know that selegiline is selective for MAO-B, but as you start upping the dosage, it starts to become less and less selective, and begin to effect MAO-A.

Because you are taking effexor, you need to be SUPER careful to ensure you don't mess with MAO-A. I think it would be quite foolish to even consider upping your selegiline dosage as long as you are on effexor.

On another note, this "regimen" you are on...is this something you've come up with in conjunction with a doctor, or is it your own "recipe"?
I understand you are suspicious of the pharma industry, and you have every right to be, but I really think you need to consult with a doctor if you haven't already. You are starting to do some serious tinkering with potentially dangerous combinations of drugs. It would be unwise to forge ahead without talking to a doc. -DG

 

[Hammilton]

Always good to bring up four year old threads.