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Stability/longevity of NBOMe's in solution?

Addam

Addam

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Aug 23, 2010
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I'll be preparing a solution of 25D-NBOMe for IM use. For other substances I typically prepare each dose one at a time prior to use, but with this I'll be using liquid measurement and thus will have to have several doses prepared.
Obviously bacteriostatic water would be what I usually use, but for longer term storage is there another solution that would have more longevity? I'm not sure how I feel about using an alcohol solution as I will be using IM as the ROA. Anyone care to offer their opinions?
 
The molecule itself is pretty damn stable, that Benzyl Oxy group isn't any less stable than the rest of he 2C structure. Theoretically, once in solution degradation can happen faster. Bacteriostatic water is usually .5 - 1% Benzyl Alcohol. Are you more concerned with the stability of the molecule or about bacterial contamination of the solution? A .5 - 1% solution of benzyl alcohol/H20 will resist contamination for a long time.
 
Today I dissolved 25C-NBOMe in isopropanol (IPA) at 1 mg/ml not for dosing purposes but storage and putting it on a carrier. I took 4 mg of 25C-NBOMe in 4 ml solvent and wet 800 mg of mannitol so that a dose of 300-500 ug will be 60-100 mg including the carrier - for insufflation.
I just put the rest of the 25C in IPA in the freezer, but was just wondering if it would be smarter to evaporate that IPA before putting the material in the freezer.

It probably is but I am not all too worried, it's not that much anyway.

The 25C on mannitol will be dry in a while which makes this one of the most handy methods I can think of.

Mind you I wore a mask and gloves etc and did the procedure in the bathroom (shower), which reminds me I better rinse the shit out of it to be sure before someone goes in there with their naked ass and absorb it somehow.
This is probably really overcautious though.
 
amanitadine said:
The molecule itself is pretty damn stable, that Benzyl Oxy group isn't any less stable than the rest of he 2C structure. Theoretically, once in solution degradation can happen faster. Bacteriostatic water is usually .5 - 1% Benzyl Alcohol. Are you more concerned with the stability of the molecule or about bacterial contamination of the solution? A .5 - 1% solution of benzyl alcohol/H20 will resist contamination for a long time.
Click to expand...

Primarily concerned about bacterial contamination or the solution becoming stagnant and unfit for IM use. It might be stored in solution up to a year. Obviously it would be refrigerated.
 
Well the word I've seen around here is "30 days" but personally, if you are using sterile technique and micron filters I would say it is gonna last a loooong time. Bacteriostatic solutions premade in medicine often have exp dates a long while in the future (+1 yr) and truth be told thats probably just being cautious. Are you making your own bacteriostatic water? if so just error on the heavier side of the concentration. Benzyl alcohol is kinda nasty to ingest but not at those concentrations.
 
Solipsis said:
Today I dissolved 25C-NBOMe in isopropanol (IPA) at 1 mg/ml not for dosing purposes but storage and putting it on a carrier. I took 4 mg of 25C-NBOMe in 4 ml solvent and wet 800 mg of mannitol so that a dose of 300-500 ug will be 60-100 mg including the carrier - for insufflation.
I just put the rest of the 25C in IPA in the freezer, but was just wondering if it would be smarter to evaporate that IPA before putting the material in the freezer.
Click to expand...

This sound ingenious. Can one be confident that the mannitol is evenly dosed after evaporation though? I'd both like to try this, and am concerned with setting the stage for an accidental overdose.
 
So, are the NBome's as stable as the 2C-x ?

I read that it should be quite stable..
 
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Would dissolving 25C-NBOMe in pure water (say 15 mg in 10-12 ml) be sufficient for long term storage if I freeze the solution immediately before and after use? This supposedly works well for LSD solutions. This might also be a solution to any looking to store for IM use like the above poster.
 
It's hard to say, I expect so, but don't have any evidence to prove it. It's far more stable than LSD though...
 
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