SSRI's- anticholinergic effect?

[MDP]

Hey,
To my knowledge, Paxil (Paroxetine) is the only SSRI with anticholinergic activity. Unlike TCA's, SSRI's do not have these side effects, with the exception of Paxil.

 

[shibireru]

Of all SSRIs I believe fluoxetine is the worst as far as anticholinergic side-effects are concerned.

I was on 60 mg of the crap for over a year and the entire time I was hardly capable of coherent thought and my memory was pure shit. I improved rapidly after discontinuation.

^ as a user of SSRI's I can say that the LNS comes on when you're starting the medication or upping your dose. I've been on citalopram 20mg for a couple months now, and erection dysfunctions are not as much of a bother as I would have supposed they would have been.

How about libido?

 

[rickolasnice]

Diphenhydramine is actually the founding father of SSRIs, it was the basis for fluoxetine I think. The full paper about it is available online, I forget the name, though.

Beat me to it.



diphenhydramine does indeed have slight S(S?)RI properties.