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Harm Reduction SSRI's and other drugs

To the poster. For me i did notice some odd interactions from Paxil and Alcohol. I was about 2-3 weeks into my Paxil rx. Had friends over and i am a big drinker so i did the usual and went hard. I felt really weird and just not right all night but after my friends left and it was just my brother, My girlfriend and I my mood went homicidal. I was hallucinating and attacking people that weren't there thinking people were attacking my girlfriend and me. ( and i have never had a issue of hallucinating, delusional or being a violent person or anything of this sort) to the point of my girlfriend and my brother being so worried and scared it was a 302 situation. Since i have not had any effect like this from any other SSRI meds or Drug/Alcohol mixture(s).

With Alcohol, Buprenorphine, Heroin, Klonopin, LSA,LSD, Mushrooms, Valium ,Xanax I never noticed a difference with Lexapro. I've been rx'ed Lexapro, Paxil, Effexor ( i think that is an SSNI though) and Prozac. With Prozac( 6 months)and effexor same as lexapro nothing negative with those drugs. I went on bupe Mat and was put on Paxil and Valium as well that was when that issue happened. So im leaning towards it being a bad reaction to Paxil itself but who knows for sure.

Be safe out there,

-B
 
ANewKindOfArmy said:
With Alcohol, Buprenorphine, Heroin, Klonopin, LSA,LSD, Mushrooms, Valium ,Xanax I never noticed a difference with Lexapro. I've been rx'ed Lexapro, Paxil, Effexor ( i think that is an SSNI though) and Prozac. With Prozac( 6 months)and effexor same as lexapro nothing negative with those drugs. I went on bupe Mat and was put on Paxil and Valium as well that was when that issue happened. So im leaning towards it being a bad reaction to Paxil itself but who knows for sure.

Be safe out there,

-B
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How long were you taking ur first SSRI before u took something that interacts with it? Tolerance has a lot to do with this. Alcohol doesn't affect serotonin except 5ht3 and as an agonist which is one reason it can cause nausea and vomiting. Though alcohol can interact with medications metabolism, the metabolism of SSRI and SNRIs aren't significant with ethanol as they aren't CNS depressants and thus not very harmful if their blood plasma levels are boosted..... Valium/xanax do not interact with SSRIs/SNRIs they potentiate each other(depends on person) to produce more sedation then either alone except those who get manic in SSRIs/SNRis.LSA,LSD, mushrooms are contradicted in ppl who take SSRis, it risks serotonin syndrome which by far is rarely fatal but is extremely unpleasant so much so it may call for a hospital visit.
 
Lysergamided said:
How long were you taking ur first SSRI before u took something that interacts with it? Tolerance has a lot to do with this. Alcohol doesn't affect serotonin except 5ht3 and as an agonist which is one reason it can cause nausea and vomiting. Though alcohol can interact with medications metabolism, the metabolism of SSRI and SNRIs aren't significant with ethanol as they aren't CNS depressants and thus not very harmful if their blood plasma levels are boosted..... Valium/xanax do not interact with SSRIs/SNRIs they potentiate each other(depends on person) to produce more sedation then either alone except those who get manic in SSRIs/SNRis.LSA,LSD, mushrooms are contradicted in ppl who take SSRis, it risks serotonin syndrome which by far is rarely fatal but is extremely unpleasant so much so it may call for a hospital visit.
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The thread posted by dirzted doesn't say that this is true and says that these hallucinogens are not likely to cause a bad interaction with SSRIs.

I personally have not experienced any sort of serotonin syndrome mixing my SSRI with LSD, Shrooms and Salvia multiple times each as well as LSA once and while I know that that is only anecdotal evidence I have heard many knowledgable posters on here say the same thing and these combos do not risk Serotonin Syndrome.

I don't know if you are are doctor, but I do not think that this statement is true.



Here is what the Blue Light thread on Anti Depressant and Recreational Drug Interactions says about mixing SSRIs and Psychedelics:


"Hallucinogens (LSD/Acid, psilocybin/Shrooms, Tryptamines, 2-ct-2,DPT, DMT etc, Salvia): These drugs can be safely combined with the SSRIs. Most people report that they need to take MORE of a hallucinogen to get normal effects. Thus, if you are taking an SSRI, you will probably need more of the drug to reach threshold effects. Some people find that they need to take more LSD, but that shrooms affect them normally. So be careful to start at a normal dose and only take more if you find that you need to.
NOTE: Do not take 'ayahuasca' while on an SSRI. Do not combine SSRIs with any kind of MAOI, such as harmaline."
 
Lysergamided said:
How long were you taking ur first SSRI before u took something that interacts with it? Tolerance has a lot to do with this. Alcohol doesn't affect serotonin except 5ht3 and as an agonist which is one reason it can cause nausea and vomiting. Though alcohol can interact with medications metabolism, the metabolism of SSRI and SNRIs aren't significant with ethanol as they aren't CNS depressants and thus not very harmful if their blood plasma levels are boosted..... Valium/xanax do not interact with SSRIs/SNRIs they potentiate each other(depends on person) to produce more sedation then either alone except those who get manic in SSRIs/SNRis.LSA,LSD, mushrooms are contradicted in ppl who take SSRis, it risks serotonin syndrome which by far is rarely fatal but is extremely unpleasant so much so it may call for a hospital visit.
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At the time of the Situation i was talking about i was about 2 weeks into taking Paxil. As i said i really didn't think it had anything to do with the mix of Paxil,Valium and Alcohol. I honestly think it was just a very very bad reaction to Paxil itself. As with most SSRI's i have been rx'ed i expected they took time to build up in the blood to get Levels to be effective. I did notice early on feeling overly angry(i am not an angry person) and just generally odd aggressive behavior and i am not an aggressive angry person but it threw me off because of the thought of it needing time to build up i figured eh maybe it was just me. Then that night as i said from the start of the day i felt off. Then that straight up psychotic breakdown. So i've been adding it up to a bad reaction to the med itself finally reaching a strong enough blood level and not so much a mix but i cannot be sure completely you know?

With LSA, My buddy was on around 150mgs of Effexor ( alot i know as i was only on 37.5mg) Seemed to take LSA quite often and at high dose. He was definitely having strong effect from it. He luckily never had serotonin syndrome. Obviously i am not saying it is safe but in his case maybe pure luck never happened. Nor did it with myself but i didn't take LSA nearly as often as him. With psilocybin mushrooms no SS for my friend nor myself. the Mushrooms i have eaten only a couple times while i was rx'ed SSRI's (NI) in the 1/8th of an ounce and 1/4 ounce doses.

If this didn't answer your question i'm sorry if i misunderstood the actual question.

Be Safe,
-B
 
This is just personal experience, so do take it as such. I have taken two types of antidepressants; zoloft and mirtazapine.

Alcohol: I never noticed much difference in the intoxication when drinking on antidepressants vs. without them. My hangovers were a lot more manageable whilst on antidepressants.
Benzos: they worked as normal and there were no increased side effects.
Methampetamine: I have been told that this can be dangerous. However, I didn't notice an increase in side effects nor a reduction of the effects of methamphetamine.
Opiates: worked as normal.
MDMA: There is a chance of serotonin syndrome. However, what I experienced were significantly diminished effects. One pill felt as though I had just had a few red bulls. There was no increased euphoria, no increased empathy but instead just a slight rise in energy.
Mushrooms: I found that there were slight diminished effects but they still worked quite well.

My experience with serotonin syndrome: this happened after combining alcohol, adderal and unknown 'ecstacy' pill bought in a club. In Australia during 2010, MDMA was very scarce and I stupidly bought a pill and split it with my girlfriend. Generally half a pill would do little for me (particarly whilst on an SSRI). After half an hour I felt quite spaced out, weird and sedated. This led me to believe that it contained DXM. After going to bed I woke up feeling terrible. I was sweating very badly (despite it not being hot) and had a lot of nausea. The following day I felt very anxious, paranoid, hot and my legs had began to involuntarily move in small jerks. The following day I was experiencing urges to hurt others and myself. At this point I went to a doctor, was given valium and told it was likely that I was experiencing a mild case of serotonin syndrome. Fortunately, it resolved itself after a few days.

Be careful mixing SSRIs with drugs.
 
I'm on lexapro and I do psychedelics all the time with no negative effects. Alcohol, weed, MXE, and kratom are also no problem. I intentionally avoid MDMA and similar drugs as well as DXM. Stims aren't really my thing but I've done them without issue as well.
 
moneyboy said:
I am on an SSRI for a relatively long time, as far as I am concerned I can consume allmost anything.

psychedelics and weed go very well with SSRI from my personal experience, when it comes to amphetamins I'd be carefull and take rather small amounts to check for interactions. one thing surely to avoid in the beginning is tramal, because it acts as an serotonin releasing agent so you may get sympthoms of serotonin-syndrome (can include high fever, vomiting, diarrhoe, dizziness, agitation and more). personally I did tramal anyway (since I am a real bad ass and try all the combinations that are risky), got a slightly strange feeling in the head while began to experiment with it but no big problems. I consumed rather small amounts of tramal (50 - 100 mg) to stay on the safe side.

If your depression is related to your substance-abuse then you should stick with the SSRI for a period of time and keep away from other substances.
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Really? I was on celexa for 3 years and it totally lessened my acid trips and made MDMA rolls non-exsistant. I'm now off it going to try DMT and didn't know what happens with SSRIs and DMT...

but good idea staying away from opiate as I am addicted to it and it sucks/...
 
I used to be on fluoxotine and that shit was useless. It made me more depressed and suicidal when I was on it :|
 
DoeJohn said:
I used to be on fluoxotine and that shit was useless. It made me more depressed and suicidal when I was on it :|
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Thanks for the off topic anecdote. Any relevant information to add? Did you do any other drugs while on fluoxetine?
 
Doldrugs said:
I'm on lexapro and I do psychedelics all the time with no negative effects. Alcohol, weed, MXE, and kratom are also no problem. I intentionally avoid MDMA and similar drugs as well as DXM. Stims aren't really my thing but I've done them without issue as well.
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I remember reading somewhere that MXE is dangerous to mix with an SSRI.

So the general consensus is:
MDMA- no go
psychs- yes, but they might lessen the experience
benzos-yup
opiates-yup
stimulants- tread lightly, best to stay away from RC's

Does the amount of time that I'm on Celexa affect the way other drugs will interact? I'm assuming it would be safer to avoid chems until I build a tolerance to the Celexa, correct?

Also, I've drank 2 beers a night for the past three nights. I didn't notice much difference in the effects, but the warning is still stuck in my mind. Is it possible that Celexa will cause internal problems when mixed with alcohol? (i.e. stomach bleeding, liver damage)
 
ksralyv2mch said:
Really? I was on celexa for 3 years and it totally lessened my acid trips and made MDMA rolls non-exsistant. I'm now off it going to try DMT and didn't know what happens with SSRIs and DMT...

but good idea staying away from opiate as I am addicted to it and it sucks/...
Click to expand...

I don't know Celexa too well, I've taken it only for some weeks but it made me very tired, so I switched to another SSRI. While I was on Venlafaxin I had no problems with LSD or psilocybin mushrooms, but I have no experience with MDMA.

I'd also like to add that as longterm user of Effexor I had no significant problems with several RCs including RC-benzos, Benzofury, Synthacaine, MPA, 3-fpm and Ethylphenidate. This might not be the case though if you're new to SS(N)RIs, everyones brain chemistry is a little different, so I would never recommend to mix.
 
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Yah for sure I couldn't sleep for a long time either. Once you build up an immunity to it though the sleep will come back. Also if you miss dreaming try taking Apple Juice. Also Melatonin helps sleep to, but it requires a bit of planning. It takes like an hour to kick in. You can get Melatonin at walmart.
 
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