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  • Trip Reports Moderator: Cheshire_Kat

SSRI's and E - first 'proper' roll - Passing out with Serotonin Syndrome

Morrison's Lament

Bluelighter
Joined
Feb 1, 2003
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Location
Berlin
I posted something about this in the Health Q&A the other day and someone suggested I write down the details in a trip report, as a warning to others as much as anything else.
As always, some background first:

I was 18, living in Devon (England), the year was 2000, and apparently the area was being flooded with good E. I hadn't tried it in any serious way, just half a lousy pill once in a while when I lived in Iceland in the preceding years, where the quality of E is rather suspect. I was a serious speed and cannabis user though, and had taken a lot of mushrooms in the past. For some reason I'd just never gotten into the E scene, but there I was in a country where the pill cost like 3 pounds a piece and there seemed to be clubs on every corner.


Everyone kept telling me how the first 'real' roll was the best and I should wait for a great pill and plan the evening. However, I was on SSRIs at the time, and it is known to reduce the power of a roll to almost zero in certain cases. So I gradually started taking less of them (over the course of nearly two weeks or so) and then stopped almost entirely a couple of days before the planned debut roll. I had noticed some side-effects from stopping entirely before, so I I was always taking an SSRI here and there, but not daily.

On cue, I was told that some kickass Mitsubishi pills just arrived. There was a rumour that they were MDA, but I honestly have no idea if they were, all I knew was that everyone else was rolling their asses off. I was advised to take not more than one pill to start with, but knowing that I had some SSRIs in my system I decided it wouldn't be enough and swallowed two immediately, followed by a third shortly after. I then walked to the club with my friends and on my way there I split another pill with a friend, so now I had three and a half very potent pills working their way through my system. I know, big mistake.

This shows how dangerous it is to know just a littlebit but not the whole story, I sort of knew the SSRI would dampen the roll and assumed this would just require me to take a larger dose of E. What happened instead was that I started getting extremely hot, my heartrate soared and I got a splitting headache. Some people at the club noticed that things were going pear-shaped, and were actually quite upset when they heard how much of the Mitsubishi I'd had in a single go. They basically sent me home with two sitters and a lot of hash, and it was just as well.

When we got home my stomache was hurting like hell, my vision was somewhat blurred, my heart was going crazy, the headache was getting quite intense, I was sweating profusely and my neck muscles were stiffening up. Eventually they stiffened so much, and got so sore, that I could barely turn my head. I also threw up a couple of times, but it was apparently too late to get much of the pills out.

I drank liter after liter of water, smoked a bunch of hash, took a couple of painkillers for the headache and basically tried to persuade my sitters that I was going to be OK. But by this time (maybe an hour and a half or so after I ate the pills, it's kind of blurry) I had started to pass out. Every time I went to the bathroom to pee (which was often because of all the water) I would pass out within a few seconds. I don't know if it was the dehydration element, the temperature element or what, but 9/10 times I barely had time to pull up my pants and flush before everything went black and I woke up on the floor.

I should also note that I was having spasms, but they were the least of my worries at the time. My legs jerked around a bit and once in a while my whole body violently jerked in a random direction. Sometimes I screamed suddenly when this happened, because the feeling of your body suddenly moving in spasms despite your trying to prevent it really caught me by surprise every time. I'd sit, holding my hands close to my body and trying not to move, and suddenly I'd throw my arms over my head and sort of fall backwards and arch my back in an instant (if that makes any sense).

This scared the shit out of everyone, but mostly felt just weird to me, the main negative was that it scared me knowing I couldn't stop these attacks with willpower.

These spasms became more frequent and so did the blackouts, but I was never totally unconscious for more than a minute or so at a time. I did hurt myself though because I kept passing out when standing up, so I landed on people and objects randomly, and also my jerks were leaving me with some aching muscles. I also woke up some people in the hallway and apparently trashed the communal bathroom by falling on everything and tearing down lightfixtures and toilet paper dispensers and such that broke my fall.


At one point I came crashing through the door of my room and scared the shit out of of my two friends by falling face down on the floor in front of them, the later told me the lock on the door broke on impact and sent a shower of splinters flying. I woke up with two very worried potheads standing over me saying something like: "Oh, shit, this time he really IS dead!"

In any case, the horribleness of it not withstanding, I learned a lesson about SSRIs and E. Even if you think they're out of your system, and even if you think taking a douple or triple dose will even things out, I advise you to think carefully about mixing the two under any circumstances. I got very lucky that time, but the experience pretty much put me off E for life. I've done it a few times since then, but the feeling always reminds me of those horrible 12 hours or so that I spent half-conscious wondering if I was about to OD or what the hell was going on.

Peace out comrades,

--- G.

EDIT: Noticed that since the software change the old posts aren't paragraphed any more, fixed that to make it readable again.
 
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Now I may be wrong here, but everything I have previously read about SSRI's suggests an INCREASE in the effects of E.
With your seratonin reputakes blocked off by the SSRI you maintain a higher level of seratonin than normal. These higher levels are caused by slowing the rate at which your brain disposes of seratonin.
Some people take an SSRI as they are coming down to draw the process out, and thus increase the length of the experience.
But anyhoo... Glad to hear that you survived. Deffinitely sounded like a close call though.
 
Damn, that was some shitty night :( . I had a girlfriend of mine who had a similiar experience.
Luckily not that bad, but she was quite out of it even a few days later.
I still doubt it was MDMA, it could seriously be PMA. Ah well look at my response over in healthQ&A
Shyrac, that's correct. But MDMA doesnt get where it needs to function when you are on a SSRI. So when you are on SSRI's and your transporters are blocked through it no MDMA can enter the cell through the transporters. SSRI have more affinity for the transporters then MDMA.
So in theory you can't get high when you are on a SSRI. But you can extend you're high when you use a SSRI halfway through your MDMA journey. Although I never heard of the latter.
 
Originally posted by Shyrac:
Now I may be wrong here, but everything I have previously read about SSRI's suggests an INCREASE in the effects of E.
But anyhoo... Glad to hear that you survived. Deffinitely sounded like a close call though.

I think you're talking about MAOI drugs, not SSRI's
 
The only really enduring effect I've noticed is that I am practically incapable of enjoying a roll. It just put me off E, whenever I feel it coming on it feels like I'm about to fall into that same spiral, even though I rationally know there's almost no chance of that being the case. I went back to my old friends speed, weed and 'cid :)
I've asked over in Health Q&A about possible enduring effects, but people seem to be generally pretty confident that it's unlikely. When dealing with human biology and recreational drugs I guess that's about as confident as you can be without lying ;)
In any case, thanks a lot for the responses! It's interesting that not only have others had similar experiences, but lived to tell about it :)
--- G.
 
Thanks for the post.

Sorry to hear about your bad experiences, but thanks for serving a warning for others intending on consuming this dangerous combo.
 
I think that the same thing could have happened to someone not taking any antidepressants at all if they took that much... I know everyone's body tolerates drugs differently, but this is coming from someone who's been rolling for a pathetically long time and who has tried just about every antidepressant on the market, save for MAOIs. You practically took 3-1/2 at once, that's never good.
 
Sorry, haven't checked the thread much recently :)

I realize I took too much, and there was even speculation there was PMA in them, but from what I am told the SSRI-MDMA combo can indeed lead to Serotonin Syndrome in those kinds of amounts. I'm not a doctor, but I think it is not common for people to develop these symptoms from just taking too much E, most reports I've read on it involve anti-depressants (but not necessarily E, interestingly).

In any case, I'd just hope people would err on the side of caution and not mix the two. After all, it is a waste of money since the pills don't actually get you off :(

--- G.
 
Actually, serotonin syndrome is more often non-fatal than fatal. I've twitched out a few times myself on just way too much X along with way too much other stuff.
 
my girlfriend was on prozac one time when we rolled, and she also took a prozac after she rolled to prevent possible brain damage and also got serotonin syndrome

be careful folks


btw she did feel the mdma, though not as much
 
wow, i'm from Cornwall and had also got pretty fucked in the head from some very strong mitsubishi's a while back
 
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