SSRI or NDRI post adminstration (hours) after cocaine adminstration

[polysubstancer]

I was wondering if taking an SSRI would lessen or maybe attenuate the (oxidative?) stress and toxicity after finishing cocaine use session?
I also wondered if taking a low dose NDRI would also lessen the stress and toxicity after cocaine? This INCLUDES very low dose methylphendiate.
Finally, would a combination of low dose buproprion and an ssri (lets take zoloft, which is also a weak DRI) after finishing coke be harm reductive?

How long after the last dose of cocaine is administered would it be good to do this IF its safe?

Thanks

 

[Amu]

Cocaine is a triple re-uptake inhibitor, so no none of this would have any significant benefit, it is simply harmful to nasal membranes and cardiotoxic due to calcium-channel blocking properties, there are some neurotoxic properties such as hyperthermia and perhaps BBB changes, and also down-regulates DA/NE/SER neurons, but it is not significantly neurotoxic, though maladaptive cognitive changes have been reported with extensive use.

However, it's calcium channel blocking properties and vasoconstriction does harm the brain in high doses:
http://www.ncbi.nlm.nih.gov/pubmed/17093073

Here's an explanation of CoQ10 protecting against toxicity:
http://www.ncbi.nlm.nih.gov/pubmed/16733807

 

[polysubstancer]

yes, your points are noted. however, what of the abilify?

 

[Nagelfar]

Since cocaine is an SNDRI (serotonin-norepinephrine-dopamine reuptake inhibitor) and SSRIs (selective serotonin reuptake inhibitors) are just a shortened spectrum of affinity in the same range action, it shouldn't be any more risky than taking more cocaine (at least in terms of their staple/named function, the metabolic pathways of the specific drugs may need be compared, but it is not anything I would be overly worrisome about if they do not pose labeled concerns on their own in that matter). What would be contraindicated is any other effects certain antidepressants may have. For example MAOIs.