Stimulants SSRI + amphetamine (warning!)

[Zcourge]

Okay, second time I'm home laying in bed and still shaking a little bit.

The cause of this is following!! Don't take speed while tappering of the anti-depressants. In my case Cipralex.

My theory is that some SSRI downregulates the adrenergic receptors as well as serotonin receptors. That is. When you tappering of the AD, and meanwhile taking speed, you have no receptors for the noradrenaline and adrenaline of the amphetamine to bind to. In that case it causes too much of these substances in the Synaptic cleft.

SO when you upregulates the adrenegic receptors again, you will have a shitload of NORADRENALINE and ADRENALINE there. BOOM. HYPERREALEASE. Heart goes to 180 BPM.

Is this theory reasonable? Someone with medicine expertise or people with a similar experiences would be great! I'm kind of exhausted.. or not exhausted because I'm still shaky 38 hours after this experience, after coming home from hospital the second time.

I can say it feels like on movies when they inject adrenaline in someone hearts to make them alive. Also there's a drug called Adrenochrome which have been seen in Fear and Loathing in Las Vegas. Which has similar effects.

Cheers!

 

[Zcourge]

What happened on the hospital was following: heart raises, hypverventilation, too much oxygen in the body, then no oxygen to the muscles, so you are so tense in every part so you can't make it to the WC. Fucking pure adrenaline rush, if my theory is right.

http://www.youtube.com/watch?v=m6kFCNsnQpQ

 

[deltakappamu]

I mean.... Seratonin Syndrome is rare..but real?

 

[Zcourge]

Sure, I considered it too at first. But since my amphetamine is a sulfate and 96,5% pure, it wouldn't have much of an affinity to the serotonin receptors. And it was therapeutic doses, no more than 100 mg a day.

I have only medicated with amphetamine these three weeks, and I'm on the tappering 1,5 week. And my symptoms where much more likely to be too much adrenaline and noradrenaline in my body than a SS. My health values was very good when being in hospital, except hight heart rate and tremors.

More of a case of that adrenaline and noradrenaline theory. Because I noticed it took of the adrenergic high while on the AD. So maybe it built up for a release for when the receptors was built up.

At least I will think so. Afraid of I have damaged me if not.

 

[missmeyet?]

Are you asking if it is real? Absolutely, and it really is not rare by most any standards. It is just often downplayed because no one wants to screw up the huge financial situation due to the fact that soo many people are so frequently prescribed anti depressants (the same reason why big pharma and even doctors are still denying that "withdrawal syndrome" is an issue with these same drugs).

http://www.medscape.com/viewarticle/582862

"The Toxic Exposure Surveillance System reviewed cases from office-based practices, inpatient settings, and emergency departments and found that during 2004, selective serotonin reuptake inhibitors (SSRIs) caused significant toxic effects in 8187 persons, leading to 103 deaths. The true incidence of serotonin syndrome and associated morbidity are likely to be much greater. This syndrome may be underdiagnosed given the fact that SSRIs are not the only contributing class of agents. Moreover, it has been suggested that more than 85% of physicians are unaware that the syndrome even exists.

Serotonin syndrome is a condition caused most often by the concurrent use of 2 or more agents that enhance synaptic serotonin levels. A triad of clinical changes -- cognitive, neuromuscular, and autonomic -- characterizes this syndrome. Specific changes may include confusion, delirium, agitation, restlessness, muscular spasms, hyperpyrexia, diaphoresis, tachycardia, blood pressure fluctuations, mydriasis, nausea, or diarrhea. Symptoms often develop within 2 hours of the increase in the synaptic level of serotonin.

 

[Captain.Heroin]

Don't SSRI's normally block amphetamine/meth?

 

[Zcourge]

In my experience it does only block the adrenal high of it. Since some reflection now and some more reading, it says amphetamine does potentate the effects of the SSRI. So it could been that it increased my anxiety which lead to several anxiety attacks when tapering off.

 

[Zcourge]

Or more likely Torsades de pointe.