SSRI + amphetamine / methylphenidate potentiation? combinations? memantine?

[defqon]

A little input i can offer is about ssri+amphetamines.

Amphetamines actually potentiate SSRI's. studies have shown the adderall boosts the plasma levels of nearly every ssri. Prozac being the most effected at a 22-30% increase.

From personal experience with extensive amphetamine use as well as various ssri's and snri's, i can say that Adderall to me felt much stronger while on prozac. When i was taking prozac adderall would feel great. huge boost of mood and confidence. When i got off prozac it wasnt the same. I began taking nearly double the dose to get similar effects.

While on effexor (SNRI) amphetamines seemed to be unaffected. I noticed no difference from when i wasn't on an antidepressant/anxiety

On venlafaxine I feel like I need more amp than I would need without SNRI. This is very noticable in comparision to my friends who get the same stuff, use at least as much as me and seem to have greater effects with one dose than I get with twice the dose. My theory being that venlafaxine is a phenetylamine just like amp and there might be some kind of tolerance that I am building up with venlafaxine. Just a wild guess though.

My experience with MPH (taken without SSRI/SNRI only 2 or 3 times, thought it was pretty lame):
Fluoxetine (Prozac) - best effects, if I waited long enough and took 30mg it felt like mdma for one hour (at least thats what I thought at the time)
Escitalopram (Cipralex) - still potentiated effects (no idea what potentiates what) and very enjoyable. Also very useful for working/studying and having sex.
Venlafaxine (Effexor) - not much of the fun left, not even close to the effects I got on prozac. Still useful for working/studying/sex.

MDPV never did anything for me. ever.

 

[novelagent]

Quick Background:
I seem to respond well to stimulants, started methylphenidate and I've taken amphetamine in the past.

What combination that is least anxiety inducing?
/QUOTE]

Anxiety induced from a psychostimulant is an indicator of toxicity-- it is dose-dependent. If you're getting more anxiety from a psychostimulant, you're on too high of a dose.

Also, given your abuse history, I highly advise taking Vyvanse. When you take a short-acting stimulant, it's easy to think, "this task is especially boring, or hard, or I don't feel stimulated enough this very second." Vyvanse is more of a set it, forget it med-- you take it, and you don't have to think of it for the rest of the day (and if you were to try to re-dose it, well, you wouldn't, because it would cause insomnia).

Add Aricept, and you'll be all set. You may want to take only 5mg of Aricept, as the combination of Aricept and Vyvanse will likely cause anxiety at 10mg/day. Aricept will repair some of the damage from your brain from the medications, and your doctor will likely be supportive and prescribe it if he/she knows your history. Good luck.

 

[Cloroxtastebad]

On venlafaxine I feel like I need more amp than I would need without SNRI. This is very noticable in comparision to my friends who get the same stuff, use at least as much as me and seem to have greater effects with one dose than I get with twice the dose. My theory being that venlafaxine is a phenetylamine just like amp and there might be some kind of tolerance that I am building up with venlafaxine. Just a wild guess though.

My experience with MPH (taken without SSRI/SNRI only 2 or 3 times, thought it was pretty lame):
Fluoxetine (Prozac) - best effects, if I waited long enough and took 30mg it felt like mdma for one hour (at least thats what I thought at the time)
Escitalopram (Cipralex) - still potentiated effects (no idea what potentiates what) and very enjoyable. Also very useful for working/studying and having sex.
Venlafaxine (Effexor) - not much of the fun left, not even close to the effects I got on prozac. Still useful for working/studying/sex.

MDPV never did anything for me. ever.

Looks like we had about the same experience with these combos.
I may not have noticed the need for more while on venlafaxine simply because of my already very high tolerance. A high doss of venlafaxine could lesson the effects of amphetamine. Venlafaxine has some adrenergic effects that can create competition regarding dopamine and to a greater extent norepinephrine receptors.

This is also true for wellbutrin, though some reports suggest they are synergistc. I for one found they don't seem do have synergistic effects in anyway.

 

[tricomb]

Correct. I would avoid desoxyn and ssri's

Because of methamphetamines more prominent effect on monoamine oxidase it causes 5HT transportation to reverse, which leads to large quantities of serotonin being released in the synaps. Combine those effects with an ssri can certainly lead too serotonin syndrome.

I've taken SSRI's with Desoxyn, often the two together in the same morning handful of pills and vitamins, and never had any problems. Did you have a problem mixing the two? I've never heard of anyone getting SS by combining the two that's why I'm curious. I don't take anti-depressants anymore as they are ineffective beyond inducing side effects, however I took the combination for quite some time which is why your post is concerning to me.

 

[Tussmann]

I've taken SSRI's with Desoxyn, often the two together in the same morning handful of pills and vitamins, and never had any problems. Did you have a problem mixing the two? I've never heard of anyone getting SS by combining the two that's why I'm curious. I don't take anti-depressants anymore as they are ineffective beyond inducing side effects, however I took the combination for quite some time which is why your post is concerning to me.

You took SSRIs for depression and not anxiety? That may open up some dialogue.

 

[Cloroxtastebad]

I've taken SSRI's with Desoxyn, often the two together in the same morning handful of pills and vitamins, and never had any problems. Did you have a problem mixing the two? I've never heard of anyone getting SS by combining the two that's why I'm curious. I don't take anti-depressants anymore as they are ineffective beyond inducing side effects, however I took the combination for quite some time which is why your post is concerning to me.

I'm sure you could/can combine the two without problema almost everytime, in some cases the doc will prescribe them together, though the risk is there. Its significantly higher than mixing other amphetamines and ssri's. It is is also very dependent on what ssri you are taking. Though they act very similar, their effects on 5HT can vary drasticaly.

I'm certainly not saying you cant, but given the option of say, desoxy, or dexedrine, the safer would be dexedrine just because of the little chance of SS from methamphetamine and a serotonin reuptake inhibitor. While amphetamines raise the peak plasma level of nearly all ssri's they have very little serotonergic effects. This is true for most, but methamphetamine stops the transportation of 5HT as well as well as not allowing uptake.

Its also very dose dependent on the ssri side of things. Some may take 20 of fluexotine or 60mg, or 50 Mg of sertraline up too 200mg. There are many variables, I was simply trying to offer the safest advice.

 

[JackiesBabyy]

NDRIs + Adderall gives mixed results, some say it potentiates the adderall while some say it lessens adderall's effect.

 

[Kenbabbs23]

I was on celexa 20 mg with 40mg of dexedrine daily. The celexa worked well at fighting anxiety to the point of feeling dopey and tired even with the dex. I switched to prozac and and actually needed low dose benzos for the first week. According to my doc he finds anectdotaly that prozac is more activating. Celexa is great for anxiety. I need an ssri to help with some of the agression i get from amphetimines and just stare at walls with only an ssri.

 

[tenshu2k]

As an update, switched from Methylphenidate to Adderral (~ 30mg) and SSRI (10mg Lexapro). Anxiety greatly reduced.

Just got Memantine and Aricept in as well, however, a little hesitant to try without a little more research.

 

[Anoymator]

As an update, switched from Methylphenidate to Adderral (~ 30mg) and SSRI (10mg Lexapro). Anxiety greatly reduced.

Just got Memantine and Aricept in as well, however, a little hesitant to try without a little more research.

To me, ritalin is anxiety in a bottle.

 

[blight12]

I take paxil and high dose meth, never had or worried about SS, is this a real concern?

I have anxiety from mdma abuse and most stims make it worse or dont help much unless the right specific dose is identified or mixed with booze.
Recently been using meth and surprisingly notice zero anxiety at all and zero need to take the edge off with booze, which is strange considering some anxiety seems unavoidable due to fundamental reasons due to how stims function.
Meth seems to completely evaporate or distract from any anxiety or triggers. I notice though that this can be risky as legitimate concerns like health or weird side effects are disregarded where they would certainly be noticed/concerned with on other stims

 

[MeDieViL]

I take paxil and high dose meth, never had or worried about SS, is this a real concern?

I have anxiety from mdma abuse and most stims make it worse or dont help much unless the right specific dose is identified or mixed with booze.
Recently been using meth and surprisingly notice zero anxiety at all and zero need to take the edge off with booze, which is strange considering some anxiety seems unavoidable due to fundamental reasons due to how stims function.
Meth seems to completely evaporate or distract from any anxiety or triggers. I notice though that this can be risky as legitimate concerns like health or weird side effects are disregarded where they would certainly be noticed/concerned with on other stims

Serotonin increase def blocks anxiety of stims in several reports ive read, lexapro also helped rit anxiety for me, they are not the magic bullet tough.