Sr 17018 / RC opioid detoxes

[4DQSAR]

Yeah - I find myself repeatedly having to point out when a paper asserts properties of a compound, they are mostly in vitro or occassionally in vivo using lab mice and don't even get me into the stains used. I was actually surprised to find a primate model and of the three, that showed the least (useful) activity.

I also find myself having to advocate for www.alltrials.net. That charity has only one goal - to legally require researchers to provide ALL the data collected in medical studies. Most people don't know that they are able to supress negative results.

Why does that matter? Well Blers in the UK may remember the CD28-SuperMAB (Theralizumab) scandal. There were serious errors right through the studies but the end result was that six volunteers were hospitalized on 13 March 2006. At least four of them had multiple organ dysfunction.

The thing is, a previous study had uncovered exactly the same issues i.e. the drug was toxic at a dose 500 times lower than that in animal models. But since no study was published, the mistakes were repeated.

If you think about it, a pharmacutical company actually has good reasons not to publish a negative study. Firtly it suggests to shareholders that maybe a billion pounds was wasted, secondly it undermines the reputations of the researchers and thirdly (and possibly most importantly), a pharmacutical company benefits from a competitor wasting a billion pounds.

So if you do one thing today, please, please, please sign the petition and provide what support you can afford. Because next time it could be you or a member of your family who ends up dead.

For context, the previous most infamous example was a large study in children of a novel antibiotic called Trovan (trovafloxin) where even the control group were not provided with the optimal dose of an older antibiotic. I've mentioned this before concerning the fact that Prozac famously was found in studies to be as effective as amitryptaline... yeah, when the lowest dose of amitryptaline was compared with the highest prescribable dose as Prozac!

 

[KrakenCat]

place rhyme with grift by any chance - no pun intended

If I'm thinking of the same reviews, I'm pretty sure those were from people who bought it hoping it would have traditional opiate effects only to be sorely disappointed. But no it does not rhyme with grift. Luckily it's available for a hell of a lot cheaper than grift is gouging for

 

[notsmokeymcpot42088]

Yeah - I find myself repeatedly having to point out when a paper asserts properties of a compound, they are mostly in vitro or occassionally in vivo using lab mice and don't even get me into the stains used. I was actually surprised to find a primate model and of the three, that showed the least (useful) activity.

I also find myself having to advocate for www.alltrials.net. That charity has only one goal - to legally require researchers to provide ALL the data collected in medical studies. Most people don't know that they are able to supress negative results.

Why does that matter? Well Blers in the UK may remember the CD28-SuperMAB (Theralizumab) scandal. There were serious errors right through the studies but the end result was that six volunteers were hospitalized on 13 March 2006. At least four of them had multiple organ dysfunction.

The thing is, a previous study had uncovered exactly the same issues i.e. the drug was toxic at a dose 500 times lower than that in animal models. But since no study was published, the mistakes were repeated.

If you think about it, a pharmacutical company actually has good reasons not to publish a negative study. Firtly it suggests to shareholders that maybe a billion pounds was wasted, secondly it undermines the reputations of the researchers and thirdly (and possibly most importantly), a pharmacutical company benefits from a competitor wasting a billion pounds.

So if you do one thing today, please, please, please sign the petition and provide what support you can afford. Because next time it could be you or a member of your family who ends up dead.

For context, the previous most infamous example was a large study in children of a novel antibiotic called Trovan (trovafloxin) where even the control group were not provided with the optimal dose of an older antibiotic. I've mentioned this before concerning the fact that Prozac famously was found in studies to be as effective as amitryptaline... yeah, when the lowest dose of amitryptaline was compared with the highest prescribable dose as Prozac!

Thank you for advocating for a safer future.

Question: When I was on triple digit c-lam daily I was offered to be a "Medical study" (On the low of course) when asking what that entailed it was basically do all the work and than show up here when it is convenient for us so we can run a myriad of tests on you. I presume if any "unknown" results were to be produced my anonymous status would be gone fast. I really would have liked to help but it was ALL RISK no UPSIDE. (This was local and perhaps would have been under the table I am not sure as it was not an offer I pursued).

HOWEVER I agree with everything you just said -- there was an meo-pcp (I forget the #) that converted to a pretty serious poison in your body. Copped some from a friend - THAN looked it up and threw it out.

This is a noble pursuit 1000% -- I presume this is the UK? I wonder if you could set up something similar stateside as a 'non profit' organization. (I know you are not the guy to ask just kinda thinking out loud, any lawyers no why I couldn't speak up).

The dream is something like the Netherlands has safe H injection sites with no get cut.

(Speaking to another user "Im sick of hearing real H doesn't exist and can't be found-- you just mean you can't get it; try getting a better plug") If you are stateside they tend to hit the keys with fet before they reach the US. (Pretty sure I saw a dealer laugh on VICE and say "Yea the ones marked have the fet; those go to the US" (Because they hate us? Likely Harder to smuggle into the US? maybe a little) -- THERE ARE DEF PARTS OF THE COUNTRY WHERE NON FETTED H DOES NOT EXIST. Believe me I saw like 20-30 batches from different places come back positive in a row. Not talking a couple of stamps either, fingers and bricks.

Hell I remember when the vinegar smell disappeared; first time I copped I did not think H had any more of a scent than coke -- vehicle smelled pretty vinegar for the whole ride back. IT IS MORE REGIONAL than "Plug based". If you still getting H with H as the only active ingredient JUST KNOW YOU LUCKY.

 

[4DQSAR]

Yeah - I realize how bad things had got when someone told me about this:

Guinea Pig Zero Jobzine

STATEMENT OF PURPOSE Guinea Pig Zero is an occupational jobzine for people who are used as medical or pharmaceutical research subjects. Its various sections are devoted to bioethics, historical...

guineapigzero.com

Now you telll me if an average person can possibly give informed consent? That is why when the whole pharmacutical industry was a bit more ethical, members of the drug discovery team were the first-into-man models. Then a decade later it had slipped and then junior doctors were employed and now, now they just use anyone who is desperate enough risk their lives for a little money.

Of course the US is a legue ahead in no-morals. They used to use (and may still use) prisoners. But now, apparently, someone realized that prisoners are often quite well read when it comes to the law (checking to see it bank robbery might be legal in certain circumstances, I assume) so now we have Guinea Pig zero - which is more or less like the UK.

Don't forget - the cases we know of only came to light because things went so bandly wrong that the media found a story. It's not like journalism is uniformly ethical. The case in Nigeria saw journalists threatened and allegedly one was even murdered to hide the truth. In the UK case, it's hard to keep a secret in a hospital - not when six people end up in the ICU and I assume used up almost all the beds.

But just how many cases has the pharmacutical industry managed to hide. Graham Chapman retold the story of being offered a part in a medical trial and on reflection, decided not. Good thing as the medication tested apparently caused impotence - forever. But that one didn't make it into the press. But read the jobzine. They reflect that they are used to find the maximum tolerable dose i.e. they get poinsed for a living. Yet even when it's not sort of in the public domain... few people care.

They don't realize that yeah, you really could die and it not become known. Pharmacutical companies always use a third party to conduct the human trials - very unethical businesses who I'm sure are expert in keeping vitcims from talking.