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SR-17018 made getting clean seriously easy

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Tetrapharmakos

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Finally was able to get a hold of some SR-17018 and it made coming off of 50mg+ Dilaudid/day surprisingly easy. Admittedly I did take a bit of pregabalin the first couple nights to help sleep, but it probably really wasn't needed and was more so my having anxiety that I might not sleep that led me to take it.

I used 75 mg doses of SR-17018 3x per day for 10 days, then begin to taper down the doses by 10 mg less each day doing 65, 55, 45, 35, 25, 15, 5, then stopped. Stopped taking any opiates at all and I feel completely fine which is amazing!

It's basically like taking Buperenorphine for a couple weeks, except, you can just stop. Highly recommend this as a tool for anyone trying to get clean.
 
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Does it feel like an opiate itself? I assume it helps WD symptoms. Will it work once WD sets in or does it only work preventatively? Seems like stopping too far in or too soon could land one in PAWS or depression but I’m very curious how this compares to something like iboga doses sub flood doses in succession either by itself or overlapped via Bernese method
 
Where were you getting that level of pharma dils from? Safe supply Canadian I presume?

Not direct sourcing obviously just curious
 
One of the most interesting drugs out there right now. I wish I knew about this when I kicked my opioid habit some months ago. Kicking was so god awful this time, I've been through a traumatic kick before but SR-17018 would have really made my recovery easier reading how this drug works on people.

I'm almost thinking about doing a little bit of opioids again and trying out some SR-17018, perhaps it's better to steer away from them though. Problem I have is that it's hard to stay away from other drugs now. Mainly dissociatives, alcohol or phenobarbital.
 
Voxide said:
Where were you getting that level of pharma dils from? Safe supply Canadian I presume?

Not direct sourcing obviously just curious
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I believe thats where the dealers have been getting them. I've heard they are very easy and very cheap to get legit pharma dils in downtown Vancouver. I'm not in Vancouver, I am a little ways away from there, but I believe that is where the dealers are sourcing it from through the safe supply situation
 
HealingEnergy14 said:
One of the most interesting drugs out there right now. I wish I knew about this when I kicked my opioid habit some months ago. Kicking was so god awful this time, I've been through a traumatic kick before but SR-17018 would have really made my recovery easier reading how this drug works on people.

I'm almost thinking about doing a little bit of opioids again and trying out some SR-17018, perhaps it's better to steer away from them though. Problem I have is that it's hard to stay away from other drugs now. Mainly dissociatives, alcohol or phenobarbital.
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If you are clean now if you ever do mess with opiates (Yeah, probably just don't lol) but if you do, I think Naltrexone will be better than SR.

"Ultra Low Dose Naltrexone" (microgram doses) will potentiate your dose, and prevent tolerance/dependence. I think if you keep using a lot you will still build an addiction but it will be slower.

But, if you use higher doses at night, "Low Dose Naltrexone" (1-5 milligram doses) it will clean your receptors every night really good, but, it only lasts a few hours...

(vs. a full 50 mg dose of Naltrexone used for alcohol cessation will block your receptors for 2+ days)

Especially if you stay at the lower end, around 1-2 mg. There are people who need opiates or Kratom for managing pain, and also use low dose naltrexone to manage their illness, and they are able to stop taking their opiate medication any time without issues.
 
This is awesome info thank you, are you in Canada or the States. I'm asking because I'd like to try this method to finally get off fent.
 
LSDiesel said:
Does it feel like an opiate itself? I assume it helps WD symptoms. Will it work once WD sets in or does it only work preventatively? Seems like stopping too far in or too soon could land one in PAWS or depression but I’m very curious how this compares to something like iboga doses sub flood doses in succession either by itself or overlapped via Bernese method
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Honestly it doesn't really feel like anything. Just stops withdrawals and I felt sober basically.
 
Is this legal in the states? How did you procure it? I'm not asking anyone to give me any, just curious if it's prescribed or OTC. I've been struggling with H/fent for 7 years, and I would like to stop without having to go through absolute hell. I've looked online but it was insanely expensive and was not in the form of single doses. Also how long did you take it? Thanks in advance glad you beat it.
 
It's not something that is illegal to possess. It isn't a drug that has been through human clinical trials and can be legally sold for purposes of human consumption.

The "insanely expensive" places you are talking about likely would not sell to you regardless even if you were capable and willing to pay those insane prices. They are biochemical manufacturers who take custom orders to manufacture chemicals for research institutions. It's insanely expensive because you are essentially renting the lab equipment and chemists required to manufacture it.
 
What about lingering withdrawal symptoms/PAWS (post-acute withdrawal symptoms). If a substance speeds up or even largely negates acute withdrawal symptoms, what about the post-acute? (For instance the boredom, anhedonia etc that creeps over an opioid addict long after the acute withdrawal is over.)

There's a dopaminergic component to opioid withdrawal, so even if say opioid receptors were brought back to homeostasis, what about the sudden lack of the dopaminergic activity by which opioids, in part, produce their reward? That's where the boredom, anhedonia etc creeps in, leading the addict back to the drug.

And in some cases, like I suspect myself, it may be that one's baseline homeostatic opioid receptor function is just naturally underactive. I feel like I can recall moments as child/teenager that felt, in retrospect, in some ways alot like opioid withdrawal (long before I ever touched opioids). When I was 16 and first tried morphine I was absolutely shocked. It was as if, "where has this been all my life"? "This is that missing piece".

So even at homeostasis I think my opioid receptors (MOR in particular) were never functioning at an average level, or perhaps my body didn't produce sufficient opioid peptides, or maybe both. Anyway, curious what the post-acute withdrawal is like from SR.

Also, how long were you on the dilaudid before switching to the SR? What ROA?
 
Delam said:
I'm really interested in this to help me kick my long term and problematic kratom addiction. Just need to look into it and try and source some in the UK.
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How bad is a Kratom withdrawl?

If Pre-gabs helped me in a Heroin withdrawl (I am also UK based btw) I would say pre-gabs would totally smash a Kratom withdrawl to pieces & would be over in days.
 
negrogesic said:
What about lingering withdrawal symptoms/PAWS (post-acute withdrawal symptoms). If a substance speeds up or even largely negates acute withdrawal symptoms, what about the post-acute? (For instance the boredom, anhedonia etc that creeps over an opioid addict long after the acute withdrawal is over.)

There's a dopaminergic component to opioid withdrawal, so even if say opioid receptors were brought back to homeostasis, what about the sudden lack of the dopaminergic activity by which opioids, in part, produce their reward? That's where the boredom, anhedonia etc creeps in, leading the addict back to the drug.
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That is the worst part imho.
I have been actual dopesick several hundred times, I can deal in a way with the vomit, cramps, lack of sleep etc but The PAWS kicks my ass.
 
SR-17018 is an experimental mu-opioid receptor (MOR) agonist being researched for pain relief, with a goal of fewer side effects like respiratory depression, tolerance, and dependence compared to traditional opioids such as morphine and oxycodone.

Key Characteristics
  • Mechanism of Action: It acts as a biased agonist at the mu-opioid receptor, primarily activating the G-protein signaling pathway while producing much less activation of the β-arrestin 2 pathway, which is associated with many negative opioid side effects.
  • Analgesic Effects: In animal studies, it produces antinociception (pain relief) with potency similar to morphine in some pain models.
  • Reduced Side Effects:
    • Respiratory Depression: Studies indicate it causes much less respiratory depression than traditional opioids.
    • Tolerance and Dependence: In certain tests (e.g., the hot plate assay), mice treated chronically with SR-17018 do not develop tolerance as readily as with morphine or oxycodone. It also causes fewer physical withdrawal signs in some models.
    • Abuse Liability: In primate studies, SR-17018 has a lower reinforcing strength (abuse liability) compared to heroin.
  • Pharmacokinetics: It is orally bioavailable, has a brain-to-plasma ratio of approximately 3:1, and a half-life of 6-8 hours.
  • Unique Properties: It can reverse morphine tolerance and prevent withdrawal in some contexts, suggesting a potential use in opioid maintenance therapy.

Research Status
SR-17018 is a research compound and is not approved for human consumption or therapeutic use. Research is ongoing to refine these compounds for potential clinical use in the future.
 
Zopiclone bandit said:
That is the worst part imho.
I have been actual dopesick several hundred times, I can deal in a way with the vomit, cramps, lack of sleep etc but The PAWS kicks my ass.
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Yeah, the hardest part is when it's been 2 months since the withdrawal ended but you feel bored and empty. I can't see how SR-17018 could help with that aspect of it.
 
Yeah the PAWS is what trips most people up. Fair enough, it could be great for saving months or years of slowly and often painfully reducing your dose from, say a large methadone dose, but if you're on a small amount of buprenorphine or methadone, the rattle can be managed with pregabalin and looking after yourself.
Could be a handy tool to save the misery of going to methadone clinics and pharmacies daily, seeing the old crowd of ex "mates" looking to pull you back down with them.
 
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