Speculated nature of interaction between 2C-C and Buspirone.

[2CEECS]

A friend of mine (seriously, not me) started taking buspirone after their first experiences with 2C-C. They are only taking 5mg twice a day, but I imagine there will be a relevant interaction between buspirone and 2C-C.

In your informed opinion, what percentage of the pre-buspirone desired dose should be attempted to assess the degree of potentiation? Are we talking a 1.5x or 10x increase in effects from a dose?

 

[ebola?]

Why do you expect straightforward potentiation? Buspar's partial agonism at 5ht1a doesn't seem particularly similar to classical psychedelics' activity at that site, so there might not be any potentiation.

ebola

 

[2CEECS]

I guess I'm just trying to give cautious advice, but as you point out, perhaps Buspar is so selective that it will have minimal impact... Nonetheless, serotonin syndrome (not to mention unexpectedly/unwantedly powerful psychedelic experiences) is nothing to mess around with. If the selectivity argument is correct, 75% of a usual dose should be a reasonable place to start--any disagreements?

(BTW, I was being overly dramatic proposing a 10x potentiation to solicit some order-of-magnitude estimates--I would've been stunned if that were a legitimate estimate, as even selegiline doesn't cause such a boost).

 

[skillet]

Yeah it wouldn't hurt to start on the low end of an active dose, but I wouldn't expect it to make much difference. Let us know what it's like though, we were discussing in another thread the much greater 1A affinity of most tryptamines compared to 2C-X and speculating that might be the cause of the subjective differences in effect, but there was nothing I could find about combinations of buspirone with 2C-X's...