Some people incapable of being affected by certain tryptamines?

[ArmouredKitten]

I've read some places that it is not unheard of for some people to have absolutely no reaction to any tryptamine psychedelics. However, I haven't been able to wrap my head around the fact that my friend gets no effect from 4-substituted tryptamines, but does react to 5-substituted tryptamines.
Can anybody shed some light as to a potential reason for this, or perhaps somebody that knows somebody that has a similar biochemical situation?
I'm really curious as to how this works and/or why. Perhaps it's overactive MAO? I just don't know.

Thanks,

-AK

 

[ebola?]

Neuroscience isn't really yet advanced enough to say with much certainty. I believe it likely due to slight genetic differences determining synthesis of various subreceptors and function of intracellular secondary messaging.

ebola

 

[cdin]

i literally experience no effect from 5-meo-dmt. Like zero. I've smoked 30mg and gotten a headache and slightly smeary vision.

 

[Solipsis]

5-MeO tryptamines act relatively strongly on 5-HT1A compared to 4-HO tryptamines and most other psychedelics which have mainly 5-HT2A agonism to thank for their psychedelic potential. So it would seem that he has unusually large or mutated 5-HT2AR populations, or something interfering with IP3 / PLC (sp?) transduction, but 5-HT1AR set-up is normal?

cdin, was the identity and quality verified? If not, perhaps you have the reverse of what I just suggested ^ . How euphoric is MDMA for you?

Maybe in some cases people have very active enzymes (or rather, a lot of them) indeed like you mention with MAO - but could be CYP p450 etc who knows really?

 

[cdin]

ok, mdma works just fine for me. The same batch was smoked by four people in a row before and after me, all of whom experienced out of body trips at ~5 - 8 mg, I have attempted this on multiple occasions, all my metabolism of other psychs, stims, opiates etc seems to be fine, although sometimes i'm a bit of a hard head(though not as bad as some folx)

 

[Contained]

I've wondered about this as well. A few months back I attempted to introduce a friend of mine to DMT but she got almost no effects, and we sat there for a while trying multiple times because I really wanted for her to experience it. Her technique was fine and we were using my glass globe/ crack pipe/ oil burner (never sure what to call it) that is exclusively used for DMT. Up until now I hadn't heard that some people actually get no effects from certain tryptamines. I'm still amazed/confused that pure vaporized DMT did nothing for my friend.