I did not write the "new age" comment.....I believe that REM is affected by a choline (precursor) deficiency acetylcholine deficiency..whatever you want to call it.............also light (sensor behind retina I think..well im pretty sure anyways), stress and other stimulating things can cause melatonin levels to drop so you wouldn't have as much of the hormone made by your pineal gland to stimulate your GABA receptors...so you would not be as tired at night also you would have trouble falling/staying asleep(REM is effected).....
If this is not right someone correct me because I am about to go research this right now....just to make sure....because I don't remember exactly..
Also serotonin think of it more as a over all well being neuro......
Originally Posted by P A
No, you're right. You didn't. I did...
An "acetylcholine deficiency" would leave you in one of two sates - fully paralytic or dead [probably from a cardiac syndrome, but who knows what wacky shenanigans such a ridiculous disorder could cook up?]. Your body requires cholinergic transmission for a lot more than just REM sleep and thinking, and there are quite a few neurons outside of your brain as well. See my posts on New Age "[insert neurotransmitter] reductionism." I'm done raging.
My academically pompous teeth clench. Again, see my above posts.
Since I don't know much about serotonin then whatever you said above prob right(i have not read what you said yet)....
Ok well maybe im wrong about the deficiency (meanings choline (precusor) acetylcholine but I could have swore it could be a cause of people have autonomic nervous system dysfunction, fybromialgia, misdiagnosis of panic attacks etc........
Also studies show that most people are actually deficient in their intake there intake of choline.....
You really need to look into it before just downing something I say....As i said before these are just my own thoughts......after my own research....
If just drives me insane for you to just basically say there is no such thing and basically tell me I have to be retarded to come up with an answer like that..I read way to much .........
So now I hope that you read your post then my answer again and then you will get it.....hopefully.
Does PCP cause damage to the cholinergic system after long term use?..............because it is a alpha-7 nicotinic receptor antagonist.
Do anyone think that maybe the reason PCP causes so many long term effects after long term use is because it destroys the acetylcholine production?
I know the other things it destroys but this one interests me............
Acute anticholinergic syndrome is completely reversible and subsides once all of the toxin has been excreted. Previously, reversible cholinergic agents such as physostigmine were used but this was found to increase the risk of cardiac toxicity. The current recommended treatment is symptomatic and supportive management.
Piracetam, Alpha-GPC and Choline (and other racetams) are known to activate cholinergic system and alleviate cognitive symptoms caused by extended use of anticholinergic drugs.
If this is not right someone correct me because I am about to go research this right now....just to make sure....because I don't remember exactly..
Also serotonin think of it more as a over all well being neuro......
Originally Posted by P A
No, you're right. You didn't. I did...
An "acetylcholine deficiency" would leave you in one of two sates - fully paralytic or dead [probably from a cardiac syndrome, but who knows what wacky shenanigans such a ridiculous disorder could cook up?]. Your body requires cholinergic transmission for a lot more than just REM sleep and thinking, and there are quite a few neurons outside of your brain as well. See my posts on New Age "[insert neurotransmitter] reductionism." I'm done raging.
My academically pompous teeth clench. Again, see my above posts.
Since I don't know much about serotonin then whatever you said above prob right(i have not read what you said yet)....
Ok well maybe im wrong about the deficiency (meanings choline (precusor) acetylcholine but I could have swore it could be a cause of people have autonomic nervous system dysfunction, fybromialgia, misdiagnosis of panic attacks etc........
Also studies show that most people are actually deficient in their intake there intake of choline.....
You really need to look into it before just downing something I say....As i said before these are just my own thoughts......after my own research....
If just drives me insane for you to just basically say there is no such thing and basically tell me I have to be retarded to come up with an answer like that..I read way to much .........
So now I hope that you read your post then my answer again and then you will get it.....hopefully.
Does PCP cause damage to the cholinergic system after long term use?..............because it is a alpha-7 nicotinic receptor antagonist.
Do anyone think that maybe the reason PCP causes so many long term effects after long term use is because it destroys the acetylcholine production?
I know the other things it destroys but this one interests me............
Acute anticholinergic syndrome is completely reversible and subsides once all of the toxin has been excreted. Previously, reversible cholinergic agents such as physostigmine were used but this was found to increase the risk of cardiac toxicity. The current recommended treatment is symptomatic and supportive management.
Piracetam, Alpha-GPC and Choline (and other racetams) are known to activate cholinergic system and alleviate cognitive symptoms caused by extended use of anticholinergic drugs.