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Solvents

A lot of stupid and/or highly unfortunate people abuse organic solvents. Their effects are inseparable from permanent nerve and organ damage.
 
As I said in another thread, they can cause sudden death - regardless of dosage, they can also cause plenty of irreversible damage - their effects tend to be dissociative in nature, so why not just take DXM, Nitrous, Ketamine etc rather than risking your life?

This is a harm reduction site so I don't think this thread is going to go down favourably. Solvents are a complete waste and the one drug where I think even trying it is more risk than good.
 
Well, its just like banging your head against the wall until you pass out - its just not a very nice high. - Never tried it and never will, its disgusting.
 
Solvents make laymen have visions they think are akin to the effects of LSD. They are in fact not tripping they are hallucinating. I know that only a few drugs can cause a total change in reality for the user. Solvents and or "huffing" is a sure fire way to lose control when abused.
 
Ether is pretty wicked, particularly when you throw some pot on top of it. I am not sure if I would classify its effects as strictly a result of oxygen deprivation. It does bind the GABA receptor. It's probably for the best that it gives you dragon fire breath and is extremely hazardous (volatile and explosive), which steers many away from abusing it.

Br J Pharmacol. 2000 Feb;129(4):731-43.
The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations.
Krasowski MD, Harrison NL.
Source

Committee on Neurobiology, University of Chicago, Whitman Laboratory, 915 East 57th Street, Chicago, Illinois, IL 60637, USA.
Abstract

The actions of 13 general anaesthetics (diethyl ether, enflurane, isoflurane, methoxyflurane, sevoflurane, chloral hydrate, trifluoroethanol, tribromoethanol, tert-butanol, chloretone, brometone, trichloroethylene, and alpha-chloralose) were studied on agonist-activated Cl(-) currents at human GABA(A) alpha(2)beta(1), glycine alpha(1), and GABA(C) rho(1) receptors expressed in human embryonic kidney 293 cells. All 13 anaesthetics enhanced responses to submaximal (EC(20)) concentrations of agonist at GABA(A) and glycine receptors, except alpha-chloralose, which did not enhance responses at the glycine alpha(1) receptor. None of the anaesthetics studied potentiated GABA responses at the GABA(C) rho(1) receptor. Potentiation of submaximal agonist currents by the anaesthetics was studied at GABA(A) and glycine receptors harbouring mutations in putative transmembrane domains 2 and 3 within GABA(A) alpha(2), beta(1), or glycine alpha(1) receptor subunits: GABA(A) alpha(2)(S270I)beta(1), alpha(2)(A291W)beta(1), alpha(2)beta(1)(S265I), and alpha(2)beta(1)(M286W); glycine alpha(1)(S267I) and alpha(1)(A288W). For all anaesthetics studied except alpha-chloralose, at least one of the mutations above abolished drug potentiation of agonist responses at GABA(A) and glycine receptors. alpha-Chloralose produced efficacious direct activation of the GABA(A) alpha(2)beta(1) receptor (a 'GABA-mimetic' effect). The other 12 anaesthetics produced minimal or no direct activation of GABA(A) and glycine receptors. A non-anaesthetic isomer of alpha-chloralose, beta-chloralose, was inactive at GABA(A) and glycine receptors and did not antagonize the actions of alpha-chloralose at GABA(A) receptors. The implications of these findings for the molecular mechanisms of action of general anaesthetics at GABA(A) and glycine receptors are discussed.
Click to expand...
 
My buddy had a big 'ole bottle of ether. If I wasn't already on 2ce and acid I'd have tried to convince him to lemme have some haha.
 
Used to "huff" "Suede and Neubuck Protector" I think the brand is "kiwi" as a child.
We stole the cans from local drug stores I'm sorry to say.
Very bad spiral, huffing things.

Starts to get dizzying and "spotty" and unconnected and unconscious feeling. kinda scary if you use it a lot.

I was told this is relevant to ether.

I almost passed out and died in a storm drain wash "huffing" that shoe cleaner shit once after a bunch of times doing it and decided to stop.
Didn't take too long to figure it out.

I'm sure if you just ripped it once for a buzz you may not get where I did with it if you can control that type of thing.

Stay far away. Bad spiral to get into huffing.
You can straight feel that crap fry your brains.
You can imagine your brain cells just popping while doing it.

I'd condone many things but not that crap. Take my advice, stuff is no good.
 
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I think huffing solvents COMBINED with spinning round in a circle really fast can have positive effects...
 
I huffed gasoline a couple times when I was a stupid kid. Once I saw my Dad walk into the shed & start to talk to me, then he dissolved into a bunch of dots... what a crazy hallucination. I then got a massive headache & puked really hard. That was my last time doing any kind of solvent.

There are so many awesome drugs... solvents are just plain stupid (not to mention dangerous)
 
Ismene said:
I think huffing solvents COMBINED with spinning round in a circle really fast can have positive effects...
Click to expand...

Come on man, be careful, you know how some people are, missing that sarcasm detector, with a hint of "oh shit, lets go try it" 8)

But yeah, part of me wants to close this, I really don't even regard these solvents as drugs when there's so much more risk compared to any potential benefits. Seem more like poison to me.

So many fun dissociatives out there if that's your cup of tea (I'm on one!). Why take ones that also could kill you on your first use? ;)
 
eye_wide_open said:
Starts to get dizzying and "spotty" and unconnected and unconscious feeling. kinda scary if you use it a lot.

I was told this is relevant to ether.
Click to expand...

Ah not really. Ether is most like nitrous, although I didn't find doing a bunch of ether as mentally stupifying as a bunch of nitrous. Nitrous feels like it is a lot more damaging to the brain than ether. The first few rags of ether gives you serious "Wah wah wahs" just like nitrous.

But then with nitrous the more you do, the weaker it gets. With ether the wah wahs get a bit weaker, but the high persists longer and longer. It has this lingering effect beyond the wah wahs and by that 4th-5th rag you start to trip really. It's pretty strange, it feels a tad like being drunk but is more like a real strong mental trip. I had a few nights where I did roughly 8-10 rags, and smoked a bit of pot in the middle of them.

The pot is really what makes things trippy. I had crazy racing thoughts a few times, way crazier that just pot by itself. I'll never forget the sound of my friend playing Punchout! for NES in the room next to us; the bell ringing especially. No auditory hallucinations but auditory enhancements. Never any visual hallucinations. It never really made me pass out, I would always go to sleep when I wanted. Also I never puked from it.

The bad part though is the breath effect. You will taste ether in your mouth for at least 24 hours if not 48-64. Forget going out in public. We walked to a gas station once for my buddy to get some cigs. As soon as we walked in the clerk knew something was up. I forget what stupid excuse we had, anyways it's dangerous stuff. I wouldn't advise searching for it, but if someone has some and offers it as long as you are prepared for the effect it's worth trying once. I have no idea about drug-drug interactions though, certainly it is not something to be mixing with depressants or probably that much else for that matter.
 
Even though ether is an organic solvent, I don't believe it's particularly harmful. I would place it in the same harm category as nitrous. I don't find ether to be very fun or interesting, but it probably won't cause any real damage as long as you get enough oxygen.

Abusing things like toluene or refrigerants will mess you up for a long time, if not forever.
 
I used to see pack man playong hide and seek with alf from "home and away" quite regularly it was some kind of shoe pretector areosol
 
solvents aren't psychedelics...8( your brain is actually melting with those, lol that's why it feels like that

and i may be wrong, but i'm pretty sure old school ether is pretty fuckin bad for ya. like as in brain damage....
 
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