wow, this is the most exciting thread I've read in ages if this is true!
I haven't tried this myself, but it seems like it could potentially just end up making the dreadful comedown last longer instead of giving a longer period of positive effects. Anyone got any experience with this practice who can confirm?
Well "standard practice" on stims is to manage the comedown with other things so this isn't a big deal for me tbh
Never tried with cathinones either now I think of it, could've many times lol
so this works works with MDMA and cathinones wow, will make my batch of methedrone a lot more interesting and my next roll too.
I asked AI about it
Parameter | MDMA (Molly/Ecstasy) | Methedrone (4-Methylmethcathinone, Mephedrone analog) | Amphetamine (Adderall, Speed) |
**Drug Class** | Substituted methylenedioxyphenethylamine | Synthetic cathinone (β-keto amphetamine analog) | Phenethylamine (weak base) |
**pKa (protonated amine)** | ~9.9 – secondary amine | ~9.6 – tertiary amine (not primary) | ~9.8 – primary amine |
**Normal urine clearance** | ~20–25% unchanged in acidic urine | ~25–30% unchanged in acidic urine | ~50% unchanged in acidic urine |
**Effect of acidic urine (pH<6)** | More ionized → less reabsorbed → faster elimination | More ionized → more renal excretion → shorter effect | More ionized → increased clearance → shorter duration |
**Effect of alkaline urine (pH>7.5)** | **Less ionized → more tubular reabsorption → prolonged plasma half-life** | **Same – dramatic increase in reabsorption** | **Same – half-life may double, e.g. from ~8h to 15h+** |
**NaHCO₃ result on drug levels** | AUC ↑ 30–50%, half-life ↑ to 10–16 hours | AUC ↑ 40–60%, half-life ↑ unpredictably | AUC ↑ 50–100%, half-life ↑ to 15–24 hrs (clinically significant) |
**Main interaction mechanism** | Renal excretion reduced because drug is non-ionized and traps back in blood | Same – weakly basic amine, trapping | |
There's some interesting papers to read that AI identified, I'll try and take a look at them when I have time.
Musshoff F. (2000). Illegal or legitimate use? Precursor compounds to amphetamine and methamphetamine.
PubMed:
https://pubmed.ncbi.nlm.nih.gov/10711406/
Summary: Reviews amphetamine and methamphetamine pharmacokinetics, including how urinary pH influences renal elimination of amphetamine.
Differentiation of Therapeutic and Illicit Drug Use via Metabolite Profiling (2025).
PubMed Central (PMC):
https://pmc.ncbi.nlm.nih.gov/articles/PMC12654502/
Summary: Reviews how urinary pH affects the renal elimination of amphetamine and methamphetamine and discusses its implications for toxicology and drug testing.
Ecstasy (MDMA) and its effects on kidneys and their treatment (Review).
PubMed Central (PMC):
https://pmc.ncbi.nlm.nih.gov/articles/PMC5126214/
Summary: Reviews MDMA-associated renal complications and notes that urine alkalinization is
not recommended in cases of MDMA-associated rhabdomyolysis because it may reduce renal elimination of MDMA.
Pre-analytical stability of drugs of abuse in urine: A systematic review.
PubMed Central (PMC):
https://pmc.ncbi.nlm.nih.gov/articles/PMC13132878/
Summary: Reviews the effects of urine pH and storage conditions on the stability of drugs of abuse, including amphetamine-type stimulants and several synthetic cathinones, with a focus on laboratory analysis rather than pharmacological effects in humans.
some posts about it too that might be worth a read.
I was sure there would already be a thread on this but I used the search engine and couldn't find one...
anyway I was curious about anyone's expierence with using baking soda to "boost" the effects of amphetamine.
I take 40mg of adderall a day.
I take 30mg xr morning and 10mg xr noon, but today i decided to spread them out because the crash was unbearable yesterday. This morning I took aprox. 5-8 mg out of the 30mg and put it in a capsule. I popped the morning dose of aprox. 25mg and didnt feel too much. Then around noon I swallowed a full spoon of baking soda. I waited till about 1:25...
I love shit like this, very very interesting! thanks for the heads up OP!
