Whenever I am at home drinking alone, it never feels like a I am fucked up. I used to drink half a fifth of vodka and be unaffected. If I tried to drink that at a bar I would be hammered. I think it has something to do with what you are doing when you are using. I also feel almost nothing from prescriptions. I am prescribed ritalin but it doesn't do anything for me. I am surprised that weed doesn't work, but your body might metabolize drugs faster than most which would explain why you don't feel what you others seem too. I am six feet tall and I need more than most people for everything to feel the effect. I need twice the prescribed amount of ritalin to feel it slightly and 4 tiimes to feel it like I "should". Are you taller than average? I am above average intelligence, and I have noticed that my less " book smart" friends seem to get fucked up faster than I do. That is all I can think of.