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Lysergamides Soaking a tab of LSD in vape liquid

red22

red22

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Josie Kins, the founder of PsychonautWiki and an employee of Mindstate Design Labs, stated that she soaked a tab of LSD in vape liquid and vaped it.

"the onset was instant, rose over a few minutes, then lasted a couple hours before dropping off."


"I am a professional psychedelic researcher. I tried vaping LSD and it worked. The psychedelic subculture has a big problem with just saying things don't work, without ever trying it for themselves. Then they repeat it to others, who spread it further... without trying it..."[ 1 ]

"oh and to clarify, the onset was instant, rose over a few minutes, then lasted a couple hours before dropping off."[ 2 ]


She soaked LSD in vape liquid for one or two days.[ 3 ]


At least 50% of LSD-25 remained in the active form even after baking the LSD-25 in a batter made from Commercial Bisquick at 300°F for one hour and freezing it for several weeks (36). Boiling a solution of 1.0mg/ml of LSD-25 in the dark up to 4 hours did not lead to a significant destruction of the LSD-25. However, LSD-25 is very sensitive to light. Its photodecomposition has been described by Niwaguchi and Inoue. Further details of the destruction of LSD-25 by ultra-violet light is described in the section under assay of LSD-25.

36. Gettner, H.H., Rolo, A. and Abramson, H. A. J. Psych. 75, 35 (1970).

39. Inoue, T., Nakahara, Y. and Niwaguchi, T. Chem. Pharm. Bull. 20, 409 (1972).
Click to expand...
LSD: A Total Study. D.V. Siva Sankar. 1975. PJD Publications Ltd.: Westbury, NY. INTRODUCTION / EARLY HISTORY OF LSD, page 50

Update: See post #7 for details about the info in the quote box.


1. Josikinz. 2025-09-10. h‍ttps://x.com/Josikinz/status/1965879102528958956

2. Josikinz. 2025-09-10. h‍ttps://x.com/Josikinz/status/1965882600008163429

3. FatherMcKennaa. 2025-09-11. h‍ttps://x.com/FatherMcKennaa/status/1965479494648823886
 
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Placebo? Doesn't heat destroy LSD? We need more first hand accounts. I myself do not believe it is active that way. But I have known to be wrong.
 
red22 said:
Josie Kins, the founder of PsychonautWiki and an employee of Mindstate Design Labs, stated that she soaked a tab of LSD in vape liquid and vaped it.

"the onset was instant, rose over a few minutes, then lasted a couple hours before dropping off."


"I am a professional psychedelic researcher. I tried vaping LSD and it worked. The psychedelic subculture has a big problem with just saying things don't work, without ever trying it for themselves. Then they repeat it to others, who spread it further... without trying it..."[ 1 ]

"oh and to clarify, the onset was instant, rose over a few minutes, then lasted a couple hours before dropping off."[ 2 ]


She soaked LSD in vape liquid for one or two days.[ 3 ]



LSD: A Total Study. D.V. Siva Sankar. 1975. PJD Publications Ltd.: Westbury, NY. INTRODUCTION / EARLY HISTORY OF LSD, page 50


1. Josikinz. 2025-09-10. h‍ttps://x.com/Josikinz/status/1965879102528958956

2. Josikinz. 2025-09-10. h‍ttps://x.com/Josikinz/status/1965882600008163429

3. FatherMcKennaa. 2025-09-11. h‍ttps://x.com/FatherMcKennaa/status/1965479494648823886
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I think if acid was vapeable that people would have figured that out a long time ago. Maybe it was a tab with some RC on it or just a placebo
 
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JackARoe said:
Placebo? Doesn't heat destroy LSD? We need more first hand accounts. I myself do not believe it is active that way. But I have known to be wrong.
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It just seems like vaping a psychedelic as popular and widespread as acid would have been figured out by now. It gets destroyed by heat
 
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fine, i'll ask mom

Z3p76RI.jpg
 
The first post contains info about two heat resistance experiments that were carried out by professionals that were reported on in this article:

Lysergic Acid Diethylamide (Lsd 25) : XXXIX. The Effect of High Temperatures on Stability. Gettner, H. H., Rolo, A., Abramson, H. A. 1970. The Journal of Psychology, 75(1), 35–40. 10.1080/00223980.1970.9916802

This is what Claude Opus said after being presented with the information in the first post and the above study:

Evaluation of the Vaping LSD Claim

What the Gettner et al. (1970) Study Supports

The thermal stability data provides partial plausibility for Josie Kins' claim:

ConditionResult
212°F for 4 hoursNo appreciable degradation
300°F for 1 hour≥50% activity retained

Vaping involves brief exposure (seconds) rather than sustained heating. If LSD survives 300°F for a full hour, brief vaping temperatures might preserve a meaningful fraction.

What the Study Does Not Address
  • Whether LSD actually vaporizes (vs. merely surviving heat without volatilizing)
  • Pulmonary absorption of LSD
  • Stability in propylene glycol/vegetable glycerin (vape liquid carriers)
  • Temperatures exceeding 300°F (many vape coils reach 400–600°F)

Notable Observation

The reported effect duration ("a couple hours") is substantially shorter than typical oral LSD (8–12 hours). This could reflect partial degradation, different pharmacokinetics via pulmonary absorption, or incomplete extraction.

Conclusion

The thermal stability evidence makes the claim more plausible than conventional wisdom would suggest, but remains a single anecdotal report, not confirmation of efficacy or safety.
 
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red22 said:
The first post contains info about two heat resistance experiments that were carried out by professionals that were reported on in this article:

Lysergic Acid Diethylamide (Lsd 25) : XXXIX. The Effect of High Temperatures on Stability. Gettner, H. H., Rolo, A., Abramson, H. A. 1970. The Journal of Psychology, 75(1), 35–40. 10.1080/00223980.1970.9916802

This is what Claude Opus said after being presented with the information in the first post and the above study:

Evaluation of the Vaping LSD Claim

What the Gettner et al. (1970) Study Supports

The thermal stability data provides partial plausibility for Josie Kins' claim:

ConditionResult
212°F for 4 hoursNo appreciable degradation
300°F for 1 hour≥50% activity retained

Vaping involves brief exposure (seconds) rather than sustained heating. If LSD survives 300°F for a full hour, brief vaping temperatures might preserve a meaningful fraction.

What the Study Does Not Address
  • Whether LSD actually vaporizes (vs. merely surviving heat without volatilizing)
  • Pulmonary absorption of LSD
  • Stability in propylene glycol/vegetable glycerin (vape liquid carriers)
  • Temperatures exceeding 300°F (many vape coils reach 400–600°F)

Notable Observation

The reported effect duration ("a couple hours") is substantially shorter than typical oral LSD (8–12 hours). This could reflect partial degradation, different pharmacokinetics via pulmonary absorption, or incomplete extraction.

Conclusion

The thermal stability evidence makes the claim more plausible than conventional wisdom would suggest, but remains a single anecdotal report, not confirmation of efficacy or safety.
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Interesting.
 
I’m with the heat destroying the L opinion but will continue to monitor others reports.
Possibly the vape temp wasn’t high enough. Why such a short trip? Does the length of trip indicate a different substance was formed by the vaping administration?
 
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neversickanymore said:
I’m with the heat destroying the L opinion but will continue to monitor others reports.
Possibly the vape temp wasn’t high enough. Why such a short trip? Does the length of trip indicate a different substance was formed by the vaping administration?
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That’s what I originally said. It could be some RC. I know that for example 2c-e can be vaporized.
 
neversickanymore said:
I’m with the heat destroying the L opinion but will continue to monitor others reports.
Possibly the vape temp wasn’t high enough. Why such a short trip? Does the length of trip indicate a different substance was formed by the vaping administration?
Click to expand...
Doesn't smoking or vaping almost anything have a shorter duration? That's certainly true of THC, MDMA, meth and even tryptamines like DMT. (Edible If taken with a maoi)
 
@SotPoker1012
it may have that.. you see it with stimulants and other substances.. but i think we should check out lsd and other psychedelic drugs as that may not be the case.. rapid onset yeah..but possibly the receptors affinity for the reception of the chemical determines the length of binding. With the administration of the stimulants we need to consider the roa possibly more due to roa absorption
 
I think it's important to distinguish between vaporization (think meth in a lightbulb) and nebulization (propylene glycol in a vape cannister.)

When you nebulizer, you're basically just aerosolizing a carrier liquid. In practical applications such as e-cigarettes, nebulization occurs at much lower temperatures (e.g., around 65°C) because nebulization does not require boiling. Partial nebulization is enough, and occurs as the vapor pressure increases with temperature.

So if LSD is soluble in the carrier liquid, and if that liquid partially aerosolizes at a low enough temperature, then I see no reason why it wouldn't work. The LSD would be floating through the air, dissolved in little liquid droplets at less than the solvent's boiling point.

I do think the instant onset is surprising. I had always been told that intravenous LSD doesn't kick in instantly, and I would assume that would be an even faster ROA.
 
Pfafffed said:
I do think the instant onset is surprising. I had always been told that intravenous LSD doesn't kick in instantly, and I would assume that would be an even faster ROA.
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I have no doubt that it came on instantly. That's because I once intravenously injected DOM, which became notorious for having a very delayed effect, and it came on instantly. I also read a comment from someone who did that decades ago and he said the same thing.

Also consider this statement about IV LSD, although the author may have been someone who just liked to tell sensationalized tales.

I have shot it several times.
I think back when they first started to experiment with it in the late 40's and 50's, I.V. was used alot.
It comes on alot quicker and peaks alot harder. It also doesn't last as long.
As long as it's in sterile ,distilled water there are no problems with the I.V. method.
Just be prepared for a different trip. It can be kind of scary having an acid trip come on so hard and fast if your not ready for it.
The largest dose I ever I.V'd was around 1000mcg.
Once along time ago a few of us shot some mixed with DMT
If you notice I said "once" ;‍) It was a careless move that I paid dearly for.

I had a friend on tour who would take a tiny little flake of fluff and shoot it. I wasn't so brave.
My advice is to just eat it and be safe

chinacat72, 2003-03-11, https://www.shroomery.org/forums/sh...oomery.org/forums/showflat.php/Number/1365055
 
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I feel bad about seeing this topic.
however
molecules can get into a smoke stream or a vapor stream of air without having been vaporized.
smoking salvinorin is about the smoke stream, not about vaporized salvinorin A.
this means a smoke or vape could work if enough liquid molecules of the active ingredient were to become launched into the stream that is inhaled.
smoking might be more likely to launch liquid particles than vaping.
 
Well, thanks for the clarification on the possibilities. Of course, initially I think of smoked, and then vaping, which is also pretty hot. But molecules moving through some kind of medium, without burning them makes more sense.

I wonder if we’ll have more firsthand reports of success.
 
JackARoe said:
Placebo? Doesn't heat destroy LSD? We need more first hand accounts. I myself do not believe it is active that way. But I have known to be wrong.
Click to expand...
The question is, how much heat? What's the vaporization point and what's the burning point? You can also vape any 4-substituted tryptamine and people say heat destroys psilocin. Saying something general like, "heat destroys lsd" needs a lot more data to have any validity.
 
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