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So who has used Tramadol?

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perthboy

Bluelighter
Joined
Oct 20, 2008
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383
My friend didn't use all of his Tramadol and so he has been kind enough let me try some of them out.
I've now tried it twice, but I haven't really got anything out of it like I was sorta expecting.
First time I did 100mg then 50mg and tonight I just did 100mg on an empty stomach.
For a weight ~80kg should I be aiming to do a higher dose or is this as good as it gets?

Also if I was to take a higher dose, would it also be wise to have valium with it as I have read Tramadol can cause seizures which I'm quite concerned about :\

Cheers
 
I've never used it, but I remember reading that it can be a very hit/miss drug, some people getting a nice buzz off it and others not getting a whole lot.
 
if it is your first time, i wouldnt take more than 200mg because it could make you feel a bit sick.
 
havent felt any buzz at all below 300mg.. have heard reports of people having seizures after taking too much tramadol hcl but have dosed 800mg+ in a 8 hour period and had no issues.

i am in no way saying that a dose of the magnitude is safe for someone to consume, i think for a first timer 200-250mg would be the go, dosing up in 50mg increments every 45 mins or so.
 
I found 100-200mg to be very lacking.

i had it given for headaches as I wanted to avoid liver damage from APAP (as when i have a migraine I can easily pop 8 X pandaine forte).

i'm glad i tested them before hand as I would have been screwed if i had to depend on them for pain relief.

are there any other opiates proscribed for migraines that do not contain APAP (or any other NSAID)?
 
Thanks for the replies everyone.
It's been about 3 hours now and I've taken another 100mg after I had finished dinner.
200mg seems like a safe dosage, and I don't think I'll push it higher until I can get valium as well
 
Tramadol is only a quasi- opiate, as in it only has effects on 3 of the 4 opiate receptor sitr/types..like kappa opiate receptor ,etc.. tramadol effects only 3 of the 4 and I cannot remember the one it does not effect but it is the one that has the more pleasing opiate effects, the euporia and all that...anyway thats why I do not care for tramadol as its only a quasi opiate(thats how it is described in my PDR-Physicians' Desk Reference book which has all the really technical chemistry and body nuroechemical stuff in it...a hard read sometimes,I often have to look up alot of whats in there in a chemistry book or something,but a handy book to have...
 
tramadol is not bad, just don't exceed 400 mg in a day and be prepared for nausea.

i took 400 MG at once stupidly one time. I had plenty of weed handy to help with the nausea, but it didn't work one bit. i threw up around 10-12 times throughout that night, often dryheaving but never feeling relieved after throwing up. the buzz was quite intense, but definitely not worth the sickness. take 200-300 MG and smoke a few bowls, you'll feel dandy.
 
total waste of time and effort - huff paint or some other rubbish if you are so desperate for cheap thrills!
 
Tramadol is only a quasi- opiate, as in it only has effects on 3 of the 4 opiate receptor sitr/types..like kappa opiate receptor ,etc.. tramadol effects only 3 of the 4 and I cannot remember the one it does not effect but it is the one that has the more pleasing opiate effects, the euporia and all that...anyway thats why I do not care for tramadol as its only a quasi opiate(thats how it is described in my PDR-Physicians' Desk Reference book which has all the really technical chemistry and body nuroechemical stuff in it...a hard read sometimes,I often have to look up alot of whats in there in a chemistry book or something,but a handy book to have...
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Tramadol does bind to all opioid receptor sites, even mu, if I remember correctly, it just doesn't have that high an affinity for them relative to say morphine. Plus, it has norepinephrine and serotonin effects as well, it's exact mechanism of action is not very well understood. It's a bitch to come off though apparently, kinda like opioid WD plus SSRI withdrawal.
 
DavisK4high247 said:
Tramadol is only a quasi- opiate, as in it only has effects on 3 of the 4 opiate receptor sitr/types..like kappa opiate receptor ,etc.. tramadol effects only 3 of the 4 and I cannot remember the one it does not effect but it is the one that has the more pleasing opiate effects, the euporia and all that...anyway thats why I do not care for tramadol as its only a quasi opiate(thats how it is described in my PDR-Physicians' Desk Reference book which has all the really technical chemistry and body nuroechemical stuff in it...a hard read sometimes,I often have to look up alot of whats in there in a chemistry book or something,but a handy book to have...
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i don;t know what you're trying to say but tramadol has a low affinity for opiate receptor *mu in particular* - the feel good one. it also has SERT and NA activity which accumulate in the efficiency of tramadols pain killing abilities. one study i've read also sates the efficacy of tramadol is determined by individual CYP2D6 genotype.

perhaps you could clear up what you mean a little better by reading the book and revising your paragraph.

just because a certain drug doesn't get you fucked up in the right way doesn't mean it's useless, it has legitimate medicinal uses.
 
WARNING:

If you are on any kind of anti-depressant such as an SSRI/SNRI or even St.John's Wort, DO NOT take tramadol.

I ended up on life-support for not knowing this little detail. Afterwards I have read many stories of people actually dying from this.

From the words of multiple doctors tramadol is an extremely unpredictable drug, many flat-out refuse to prescribe it to all but cancer patients.
 
From the words of multiple doctors tramadol is an extremely unpredictable drug, many flat-out refuse to prescribe it to all but cancer patients.
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I've been told the same thing, unpredictable and with a side effects/medical benefit ratio that's way off.

It's a shame because we don't really have any decent, mid-strength opiates. It's basically codeine or morphine/oxy, with only trams in between.
 
If you intend to use this drug and it's not prescribed, then at least read up well on the pharmacology, contraindications, pre-dispositions etc. As mentioned, Tramadol affects people differently, and as Dr.Genome has said, interactions with drugs that act on SERT etc can be life threatening.
 
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