Slow subcutaneous infusion of flumazenil for the treatment of long-term, high-dose benzodiazepine users

[pally pete]

I'm in a daily living hell due to my 12 years of benzo misuse. As the title says - I think this may be my only chance...

Does anybody here have any experience with this method?

 

[pally pete]

No and I would never even consider it

High dose long term benzo users taking a GABA antagonist?! Sounds like the perfect recipe for constant seizures.

Low risk of seizures with slow flumazenil infusion and routine anticonvulsant prophylaxis for high-dose benzodiazepine dependence - PubMed (nih.gov)

Slow subcutaneous infusion of flumazenil for the treatment of long-term, high-dose benzodiazepine users: a review of 214 cases - PubMed (nih.gov)

Flumazenil. A preliminary review of its benzodiazepine antagonist properties, intrinsic activity and therapeutic use - PubMed (nih.gov)

Frontiers | Continuous Infusion of Flumazenil in the Management of Benzodiazepines Detoxification | Psychiatry (frontiersin.org) (Most informative)

 

[pally pete]

Low risk of seizures with slow flumazenil infusion and routine anticonvulsant prophylaxis for high-dose benzodiazepine dependence - PubMed

High-dose benzodiazepine (BZD) dependence represents an emerging and under-reported addiction phenomenon and is associated with reduced quality of life. To date there are no guidelines for the treatment of high-dose BZD withdrawal. Low-dose slow flumazenil infusion was reported to be effective...

pubmed.ncbi.nlm.nih.gov

"We evaluated the occurrence of seizures in 450 consecutive high-dose BZD dependence patients admitted to our unit from April 2012 to April 2016 for detoxification with low-dose slow subcutaneous infusion of flumazenil associated with routine anticonvulsant prophylaxis"

Am I reading that wrong? They administer flumazenil with anti convulsant medications?

That seems to be the case.