Opioids Simultaneous Sublingual and Nasal Administration of Buprenorphine & 2 other questions

[GRNBTTSTY]

Simultaneous Sublingual and Nasal Administration of Buprenorphine & 2 other questions

I have yet to try too take the Subutex pill in the way that it was intended, sublingually, primarily because I am an impatient man. But I was thinking, as I will be acquiring some more pills shortly, that I might try this; my preferred dose is 2 mgs nasally and I will put half that up my nose and "eat" the other half. My question is, is the sublingual ROA significantly longer then the insufflated one? Would it be worth splitting it up like that?

I've got two more minor questions that I figured I would ask in this thread instead of starting two more threads for short questions.

I rather like the long half life of Bupe and was considering purchasing some powdered Methadone as my next Opioid buy. But I was having some doubts based on my past couple experiences with it and a lot of stuff I read in the Methadone MegaThread. Is it at all similar to Bupe (or anything for that matter), a long winded and "mild" Opioid high? Lots of people say they don't find Bupe abusable but it is one of my favorite Opioids.

And my last question, does your weight effect the dose you need to take (of any drug) even if the ROA isn't oral?

Thanks guys! Happy Drugging!

 

[Blind Melon]

OK, I have extensive experience with both substances.

First off, these are odd drugs. Some people (one of my best friends) loves Suboxone (which is just an opioid), and hates Methadone (a real, albeit synthetic, opiate). I personally have never felt recreational effects from Bupe, while I did feel a sort of high on the same dose of Methadone for over 5 years. True the initial euphoric high goes away, but one is left with a sense of contentment, a constant state of mild relaxation, and an almost mild glow that never quite goes away.

Methadone should only be orally ingested, as the oral bioavailability is 80+%, there is simply no reason to shoot it, especially considering the artificial sweeteners they add into most liquid varieties, not to mention the wafers are huge.

Subutex can be shot up, but I recommend against it. Shooting pills is dangerous. At least IM it if you insist on using the needle with this drug. Suboxone, whether wafer or strip should not be shot up either, especially considering the naloxone (which is actually primarily a scare-tactic, as the Bupe has a higher affinity for the receptors, however the naloxone will seriously fuck with any other opiates you have in your brain). People do shoot Suboxone/Subutex, but then again people inject "etomorphine/krokodil" too (nothing against either user).

The oral bioavailability of Bupe is around: 15%, don't swallow it.
The sublingual bioavailability of Bupe is around: 30-50%, which is how the pills are intended to be consumed.
The IM bioavailability of Bupe is around: 87%, but it is a dangerous process.
The nasal bioavailability of Bupe is around: 60+%, so if you have Subutex sniff it up, but don't sniff the Suboxone, too much filler.

Lastly, my experience with different ROA: Eating a substance tends to last the longest (in general). Sniffing or smoking the drug tends to kick it in faster, however the duration usually seems shorter lived than when orally consumed. IVing especially or IMing a drug tends to (obviously) kick it in much quicker, makes the peak more intense, but unfortunately has the shortest duration. Consequently, depending on the substance at hand, I generally employ a variety of ROA.

Example:
Dilaudid: IV
Methadone: Drink
Subutex: Insufflate
Suboxone: Sublingual
Klonopin: Eat

 

[thesameoldfears]

^ IM injections are less safe than IV if you don't have a substance specifically prepared to be used that way, ie in a medical vial. Or at the very least micron filtered.

 

[Blind Melon]

^which is why I wouldn't IM Subutex, Suboxone, or even Methadone (pointless, and potentially dangerous). But BRRNBTTSTY asked, so I answered.

 

[GRNBTTSTY]

Thanks Blind Melon. That was sort of what I was looking for. And thanks for the Bioavailabiliy data of Bupe, it wasn't up on the Wiki. Do you perchance know the rectal availability?

I did get the vibe when reading up on both that they where "odd". Thanks for affirming my suspicions.