nuke
Bluelighter
- Joined
- Nov 7, 2004
- Messages
- 4,190
Scratch my last comment, I made it even simpler...
Btw, this one looks really cool in 3d...
What on earth?? Stability much??
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N&PD Moderators: Skorpio
Simplest molecule filling morphine rule?
- Thread starter dread
- Start date
What on earth?? Stability much?? 
dread
Bluelighter
Hehehe... I'm not saying it would be stabile. I was just playing with the idea of making the most simple (least atoms) molecule... in theory.
Now the real challenge is for one of you chemists to make this chemical...I would generally say that the 4 hexane/benzene rings that morphine has is optimal for receptor binding, tons of hydrophobic interactions for induced fit into the active site... and also as it is well known that modifying those 2 hydroxyl groups on morphine to something more lipophylic (i.e. acetyl groups [heroin]) increases the Km value for binding
/navarone/
Bluelighter
Well mates if what we're doing here is simply "playing with words" then i guess my molecule is a winner:
"Wattafakamine" (C7HN)
It has an aromatic benzene ring (red)
It has a quaternary carbon (green)
It has a tertiary amine (blue)
And finnally
It has a 2 carbon chain (yellow) between the amine and the quaternary carbon (never said it had to be an unbranched saturated alkane
)
dread
Bluelighter
:D :D :D
we have a winner!
although, if anyone could ever make such a chemical, the benzene would be so twisted it would probably lose it's aromaticity...
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dread
Bluelighter
Perhaps it could be stable if kept in absolute zero temperature?
in theory...Scratch my last comment, I made it even simpler...
Btw, this one looks really cool in 3d...
As a chemist, this is an interesting compound though pretty much impossible to make. Tetrahedrane (C4H4) is a theorectical compound that possesses extreme angle strain. But, a derivative with tert-butyl group at each apex has actually been synthesized!
Check out http://en.wikipedia.org/wiki/Tetrahedrane
As far as simple opiates.....Levorphanol
Nagelfar
Bluelight Crew
I know extremely little about chemistry, nigh nil, but reading about 'nanoparticles', could those somehow potentially make things work in ways that a 'regular' size particle in a molecule wouldn't normally: to make something usually unstable, stable?MurphyClox
Bluelighter
- Joined
- Mar 26, 2008
- Messages
- 1,416
Sorry, but the last couple of structure suggestions are plain nonsense. No use talking about 'the smallest molecule filling the morphine rule' if the suggestion are totally devoid of any chemical significance.
This thread is turning towards insignificance.
- Murphy
Agreed in terms of opiate activity, no chance!
negrogesic
Bluelight Crew
Though not especially simple, this one in interesting (known as ethoheptazine). It sort of looks like a DRI (like MPH):
dread
Bluelighter
It does look like a DRI. Maybe it even acts as one...
fastandbulbous
Bluelight Crew
Though not especially simple, this one in interesting (known as ethoheptazine). It sort of looks like a DRI (like MPH):
Looks more like pethedine with a methylene group added to the piperidine ring!
/navarone/
Bluelighter
Azepane ring you mean..
fastandbulbous
Bluelight Crew
No pethedine has a piperidine ring at it's heart. Add a carbon atom into the ring & you get ethoheptazine
dread
Bluelighter
Why not just say "looks like a pethidine with a 1 carbon larger heterocycle"
it would leave no room for confusion
negrogesic
Bluelight Crew
it's a schedule 5 drug, while proheptazine is c-I. I wonder if it has
appreciable DAT affinity.
