Limpet_Chicken
Bluelighter
Etifoxine is a benzodiazepine-like drug, a benzoxazine actually, and it acts as an allosteric positive modulator at GABAa receptors, selectivefor beta2/beta3 subunit-containing GABAa receptors.
From memory, this is similar to valerian, and doesn't loreclezole bind at these target sites as well?
I ask because I have for years and years been wanting to find more loreclezole-site ligands (positive modulator/full agonist types of course not antagonists or inverse agonists)
Mainly because I am fascinated with the effects that valerian has on me, not so much in its capacity as a sedative-hypnotic (I'm pretty tough to put down in that respect where GABAa-ergics are concerned. with valerian root extract being the most powerful oneirogen I have ever encountered. So much so that it made me think almost, like, say, ever seen the episodes of the original star trek, in the mirror universe? well valerian might be that universes's waking-time psychedelic, if psilocin were the asleep-oneirogen.
Because the effects on REM that valerian has on me are absolutely mental. Not awake, its just a mild sedative, but once I've GOT to sleep its really in-you-fucking-FACE, LC, chew on some of THIS for size!, its like being tossed and buffeted by constant barrage of lucid, intense vivid as hell crazy dreaming. Good fun but a very rapid tachyphylaxis to the effect.
Anyone know which constituents of valerian are those responsible for the oneirogenic properties. And, nodding aside, while I'm taking opioids chronically, I don't dream much at all, well, I do I am sure, but i DON'T remember ever remembering any fragments of dreams. REM sleep sure, dreaming I don't know for sure but I don't seem to dream on opiods. And I can't stop taking them, so I've been really curious about other drugs, that might act on the same targets as valerian (Valeriana officianalis, being the spp.).
I'd LOVE to try loreclezole, but have got absolutely no clue as to what the human dose range is.
From memory, this is similar to valerian, and doesn't loreclezole bind at these target sites as well?
I ask because I have for years and years been wanting to find more loreclezole-site ligands (positive modulator/full agonist types of course not antagonists or inverse agonists)
Mainly because I am fascinated with the effects that valerian has on me, not so much in its capacity as a sedative-hypnotic (I'm pretty tough to put down in that respect where GABAa-ergics are concerned. with valerian root extract being the most powerful oneirogen I have ever encountered. So much so that it made me think almost, like, say, ever seen the episodes of the original star trek, in the mirror universe? well valerian might be that universes's waking-time psychedelic, if psilocin were the asleep-oneirogen.
Because the effects on REM that valerian has on me are absolutely mental. Not awake, its just a mild sedative, but once I've GOT to sleep its really in-you-fucking-FACE, LC, chew on some of THIS for size!, its like being tossed and buffeted by constant barrage of lucid, intense vivid as hell crazy dreaming. Good fun but a very rapid tachyphylaxis to the effect.
Anyone know which constituents of valerian are those responsible for the oneirogenic properties. And, nodding aside, while I'm taking opioids chronically, I don't dream much at all, well, I do I am sure, but i DON'T remember ever remembering any fragments of dreams. REM sleep sure, dreaming I don't know for sure but I don't seem to dream on opiods. And I can't stop taking them, so I've been really curious about other drugs, that might act on the same targets as valerian (Valeriana officianalis, being the spp.).
I'd LOVE to try loreclezole, but have got absolutely no clue as to what the human dose range is.