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Similarities between etifoxine and loreclezole/valerian

Limpet_Chicken

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Etifoxine is a benzodiazepine-like drug, a benzoxazine actually, and it acts as an allosteric positive modulator at GABAa receptors, selectivefor beta2/beta3 subunit-containing GABAa receptors.

From memory, this is similar to valerian, and doesn't loreclezole bind at these target sites as well?

I ask because I have for years and years been wanting to find more loreclezole-site ligands (positive modulator/full agonist types of course not antagonists or inverse agonists)
Mainly because I am fascinated with the effects that valerian has on me, not so much in its capacity as a sedative-hypnotic (I'm pretty tough to put down in that respect where GABAa-ergics are concerned. with valerian root extract being the most powerful oneirogen I have ever encountered. So much so that it made me think almost, like, say, ever seen the episodes of the original star trek, in the mirror universe? well valerian might be that universes's waking-time psychedelic, if psilocin were the asleep-oneirogen.

Because the effects on REM that valerian has on me are absolutely mental. Not awake, its just a mild sedative, but once I've GOT to sleep its really in-you-fucking-FACE, LC, chew on some of THIS for size!, its like being tossed and buffeted by constant barrage of lucid, intense vivid as hell crazy dreaming. Good fun but a very rapid tachyphylaxis to the effect.

Anyone know which constituents of valerian are those responsible for the oneirogenic properties. And, nodding aside, while I'm taking opioids chronically, I don't dream much at all, well, I do I am sure, but i DON'T remember ever remembering any fragments of dreams. REM sleep sure, dreaming I don't know for sure but I don't seem to dream on opiods. And I can't stop taking them, so I've been really curious about other drugs, that might act on the same targets as valerian (Valeriana officianalis, being the spp.).

I'd LOVE to try loreclezole, but have got absolutely no clue as to what the human dose range is.
 
Valeric acid is a hydroxy group away from ghb or a nh2 from gaba. So thats my best bet. But in my experience valerian did nothing compared to synthetic gaba modulators like alprazolam
 
It's valerenic acid (and related sesquiterpenes) that is likely responsible for sedative effects and effects on sleep-wake cycle, so possibly also for oneirogenic properties you mention though I never myself noticed them.
 
Ya me either but i was using xanax so i could of been crosstolerent maybe
 
Etifoxine sounds similiar to etaqualone, I don't know which number sub-units its selective for but I iirc it hits the beta group.
 
it could be some other component that is not acting on gaba but on some other targets...as far as i know gaba levels are high in all phase of sleep while for example acetylcholine levels are high only in the rem phase and low during non rem sleep
 
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