Silly Volumetric Dosing Question

[johndoe123321]

Hi everyone,

Pardon if this has already been asked a million times. I have a 27 mg Concerta but I don't want to take the whole thing at once, as my tolerance is low.

So, I removed the outer coating (saved it), cut off the brown sponge part, and cut away the inner plastic membrane from the 27 mg. Concerta.

I ground the compacted powder into a fine paste and boiled it into a few mL of water.

I yielded 38 mL after the powder had fully dissolved into the water. As it was boiling, it made my kitchen smell like a chemical and I shut it off because I was worried about the vapors. I'm hoping I didn't boil off any of the active chemical?

Seeing as I boiled approx. 21 mg. methylphenidate and I want to take 5 mg, I'm assuming I'd have to dose 9.5 mL of this solution.

Please tell me if my math is right (and whether it would even apply based on the chemistry of the matrix used to bind MPH).

I tried a 99% IPA extraction before, but I think I just made myself sick by letting the final product evaporate at room temperature, so I don't wanna do that again. Thank you

 

[Cult315]

wow I did this all fucked up and had myself so confused. I came here to ask my own question about coke and ODSMT and spent an hour doing some other motherfuckers math homework

But I believe your math isn’t far off(I would get somebody else’s input, maybe @Kief Richards will respond), though if my math is correct 9.5ml would be around 5.22mg, where 9ml even will be 4.95. I guess it depends on how close to an even 5mg you want to be. If you want it to be easier, you could draw up another 4ml of water in an oral syringe and squirt it into your solution, making it an even .5mg/ml(so 5mg per 10ml). Honestly that’s what I would suggest.

Edit - also, as far as I know you didn’t need to boil the methylphenidate to get it to dissolve in water, and I’m unsure why you took that step. Correct me if I’m wrong but I believe it should dissolve freely in room temperature water. If I’m wrong I apologize, but if not then I would suggest avoiding that step next time and just stir til it’s dissolved, then add the desired amount of water to make dosing the easiest.

Also if my post does help you, you can thank Kief because I didn’t know a thing about volumetric dosing 2 days ago and ever since reading his post on it I’ve been looking into doing it with every drug I plan on buying just because. I like playing with my drugs as much as I like consuming them lol

 

[Cult315]

This is AI overview so take it with a grain of salt -

• azards: When heated to decomposition, methylphenidate hydrochloride emits very toxic fumes of hydrogen chloride and NOx.
  
  
• Incompatibilities: It is incompatible with alkalis and solutions of barbiturates.
  
  
• Stability: Methylphenidate degrades to ritalinic acid faster at 20°C than at 10°C.
  
  
• Metabolism: Methylphenidate is primarily metabolized by de-esterification to ritalinic acid, which is pharmacologically inactive.

Water boils at 100°C, so I would assume your MPH reached far over 20°C. I know nothing about chemistry, but it sounds like boiling it in only a few ml of water could possibly cause the MPH to degrade into an inactive compound.

 

[johndoe123321]

This is AI overview so take it with a grain of salt -

• azards: When heated to decomposition, methylphenidate hydrochloride emits very toxic fumes of hydrogen chloride and NOx.
  
  
• Incompatibilities: It is incompatible with alkalis and solutions of barbiturates.
  
  
• Stability: Methylphenidate degrades to ritalinic acid faster at 20°C than at 10°C.
  
  
• Metabolism: Methylphenidate is primarily metabolized by de-esterification to ritalinic acid, which is pharmacologically inactive.

Water boils at 100°C, so I would assume your MPH reached far over 20°C. I know nothing about chemistry, but it sounds like boiling it in only a few ml of water could possibly cause the MPH to degrade into an inactive compound.

Shit, you're right. I thought it would be different because the osmotic time-release pills are bound with HPMC (soluble in water). That's why you can't just cut open, crush, and consume. The fillers are bound to the active chemical at a molecular level

 

[fairnymph]

Why would there only be 21 mg of methylphenidate in your solution?

I can’t see why you would use heat. As explained, that seems unwise.

I’m going to have to do some more research on breaking time releases because I don’t have much personal experience.

 

[johndoe123321]

Why would there only be 21 mg of methylphenidate in your solution?

I can’t see why you would use heat. As explained, that seems unwise.

I’m going to have to do some more research on breaking time releases because I don’t have much personal experience.

Outer shell contains 22% of MPH (so, for a 27 mg. Concerta, you'd be left with 21 mg. of MPH after removing the IR outer coating.

I came across a comment from 2013 that said boiling the crushed powder works great and I figured what the hell. I haven't dosed with the solution yet because I was worried about the safety profile.

I'm guessing there's no good way to go about making it work.

 

[fairnymph]

Ahh, thank you. There are good ways about making it work but it’s going to be different for every formulation and will require some tinkering and quite possibly some more advanced techniques and equipment.

 

[Cult315]

As I stated above I know nothing about chemistry, but my best (uneducated) guess would be you’d have to find a solution that one of the two compounds is soluble in where the other one isn’t, and separate them that way. Both being soluble in water is going to make it difficult to separate, unless one dissolves much faster than the other or one dissolves better in heat(which in this case seems to not be advised, anyway), or on the opposite end better in colder temps.

I gave up on time released meds about the time you couldn’t just rub the outer coating off of them anymore. I tried many methods for various drugs to break time releases and other forms of altering them that I’d found guides for online, which usually just resulted in wasted drugs or some sort of mess all over my kitchen. Or a disgusting, lingering smell throughout the house. Sometimes it’s just better to find a source for better drugs than to try to play amateur chemist when you don’t have the skills to do so lol