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should you stop nootropic use before a session.

G

Godzilla

Bluelighter
Joined
May 4, 2010
Messages
397
Ok first of all apologies for all of the recent posts. I have a little research experiment that I want to conduct and need some last minute info.

I started to take the below list of nootropic supplements about two weeks ago with nice results. Should I discontinue the use of these supplements a day or two before the next session. Thanks

lecithin
DMAE
piracetam
omega 3/6/9
Choline
Ginkgo
mutimivamin natural source
berry complex
tea complex
immune defense
 
I remember Xorkoth saying something about piracetam potentiating the living shit outta 2C-E. I think he had a near ++++. But yeah, potentiating isn't always a good thing when you end up getting you ass kicked harder than you ever thought possible.

So yeah i'd say either start you next experiment out with a reduced dose, or, stop you nootropic regimen for a couple of days before you trip.
 
I never stop taking nootropics before the trip.

I remember Xorkoth saying something about piracetam potentiating the living shit outta 2C-E. I think he had a near ++++
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I guess this is his trip-report

I also found that nootropics potentiate 2C-E, so maybe it is good idea to lower your dose by 1-3 mg to get expected effects.
 
^ I dont think berry complex and tea complex are useless. There is alot of evidence that the proanthocyanadins and other berry-specific polyphenols are hugely beneficial to the body, and the EGCG and tea polyphenols have also been proven time and time again in many medical studies to be immensely beneficial. Perhaps by "useless" you meant as nootropics, which is an arguable point, though I am pretty sure all those potent antioxidants are very good for nerve/brain functions as well as neurotransmitter production and regulation, so I think throwing the term "useless" at them is not warranted. Perhaps not "necessary" by certainly not "useless" either.
 
DwayneHoover said:
^ I dont think berry complex and tea complex are useless. There is alot of evidence that the proanthocyanadins and other berry-specific polyphenols are hugely beneficial to the body, and the EGCG and tea polyphenols have also been proven time and time again in many medical studies to be immensely beneficial. Perhaps by "useless" you meant as nootropics, which is an arguable point, though I am pretty sure all those potent antioxidants are very good for nerve/brain functions as well as neurotransmitter production and regulation, so I think throwing the term "useless" at them is not warranted. Perhaps not "necessary" by certainly not "useless" either.
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Of course, in controlled lab tests. Taking these supplements everyday, from an unknown supplier, is bad. Period. Who grew those berries? Who grew that green tea? Is it organic? Is it GMO? And what brand is it? Do you want to get your supplements from the lowest bidder? I don't

If one is taking an antioxidant supplement simply because it's an antioxidant, then throw it out. Our bodies rely too heavily on redox for us too be messing with our own endogenous antiox system. I don't know about the OP, but there are people who really do showel these pills down like candy thinking it's all good. Well, it's not.

Why could she/he not just eat berries and drink tea?


Link
Despite several human studies that showed no toxicity of tea polyphenol preparations and that the major adverse effects associated with consumption of high doses of tea preparations are due to gastrointestinal irritation, there have been a number of recent case reports of hepatotoxicity related to the consumption of high doses of tea-based dietary supplements (10-29 mg/kg/day po) (18 ). In nearly all cases (eight out of nine), patients presented with elevated serum alanine aminotransferase (ALT) and bilirubin levels. In two of nine cases, periportal and portal inflammation were observed. All cases resolved following cessation of supplement consumption. A causative role for the green tea preparations is suggested by the fact that reinjury was observed following rechallenge with the same preparations. The authors of these reports, however, could not conclusively rule out the involvement of potentially hepatotoxic pharmaceutical agents such as acetaminophen or other dietary supplements. One intriguing possibility is that susceptible individuals have a polymorphism in a key biotransformation pathway for the tea polyphenols, such as low activity COMT, which increases exposure to the unmetabolized parent compound. Such possibilities need to be further explored.
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Why toxicity may occur
We conclude that p.o. administration of EGCG or Polyphenon E at a daily dose of 800 mg (based on the EGCG content) for 4 weeks is safe and well tolerated in healthy human subjects. Repeated green tea polyphenol administration at a high daily bolus dose (800 mg once daily) results in a >60% increase in the systemic exposure of EGCG, possibly because of inhibition of presystemic elimination of this catechin. Repeated administration of EGCG and Polyphenon E at a daily dose equivalent to the EGCG content in 16 Japanese-style cups of green tea for 4 weeks did not provide protection against UV-induced erythema.
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Despite several human studies that showed no toxicity of tea polyphenol preparations and that the major adverse effects associated with consumption of high doses of tea preparations are due to gastrointestinal irritation, there have been a number of recent case reports of hepatotoxicity related to the consumption of high doses of tea-based dietary supplements (10-29 mg/kg/day po)
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^^These are only a few examples, the quickest I could find. Sure I could find more but I honestly don't want to. And yes there are plenty of examples of positive effects too I'm not saying this stuff is poison. I'm just saying people rely way too much on supplements. My advice, drink tea and eat berries. This is how one truly reaps the rewards from them.
 
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Of course, you could come right back with probably 50x more links shitting on my articles. That's fine. That's legitimate. One needs to decide for themselves. However I threw all my "antioxidant" supplements away. I now choose to actually consume the food. kCals count too for what it's worth :\
 
Piracetam can unpredictably alter the strength and effects of psychedelics. Not always for the stronger, or more pleasant.

A wonderful substance on its own, best not combined with other serious psychedelics or dissociatives.
 
Thanks I'm gonna drop the Choline. I only take one capsule of the other ones daily. I don't believe in max dose of anything. Minimum doses for an effect is what i like.
 
actually i do use New chapter whole omega extra virgin fish oil
100 wild caught salmon, all the other sources are similar
 
Just noticed this today, so thought I'd post here on it since it was (sort of) brought up. Supports the suggestion to just eat the foods instead of taking pills. This reports significant results with just a single serving of blueberries per week... VERY easy, not to mention amazingly delicious! (DelMonte just came out with a cup of fresh refrigerated blueberries and also mixed berries in juice in the fresh produce grocery store section that I've become addicted to... $1.50 or less, and SOOOO crisp and yummy! Just typing this is making my mouth water and makes me want to go get one right now, haha! I think I shall.

Blueberries May Lower Chance of High Blood Pressure

http://news.yahoo.com/s/livescience...jY29yZGlvbl9zY2llbmNlBHNsawNibHVlYmVycmllc20-

For convenience here the 1st third only to save space:

Biological compounds found in blueberries may lower the risk of developing high blood pressure, according to a new study.

The researchers, which tracked volunteers over 14 years, found that the people who consumed at least one serving of blueberries per week were 10 percent less likely than those who ate no blueberries to develop high blood pressure, which is also known as hypertension.
Blueberries contain compounds known as anthocyanins, which are one type of flavonoid. Flavonoids, which are also found in dark chocolate, red wine and tea, are antioxidants and have been shown to reduce the risk of cardiovascular disease. But the new study showed that anthocyanins in blueberries may work better than other flavonoids at keeping blood pressure low.

"Of all of the flavonoids, anthocyanins seem to be the most protective in terms of reducing risk of hypertension," said study researcher Aedin Cassidy of the University of East Anglia in England.

Besides blueberries, anthocyanins are found in blackcurrants, blood orange juice and eggplant, said Cassidy, a member of the university's Department of Nutrition. Because an average portion of these fruits and vegetables (about 500 milligrams, or 0.02 ounces) can contain very high amounts of anthocyanins, incorporating them into the diet is "a very achievable way of reducing hypertension," Cassidy told MyHealthNewsDaily.

Blueberries and blood pressure

In the study...
 
I agree that when we're dealing with supplements that can easily (and even cheaply!) be found in natural sources. There is just a plethora of evidence to suggest that the efficacy of supplements is significantly reduced by the body's inability to metabolize/absorb the supplements as compared to natural foodstuffs.
 
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