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Health Shifting to Prescribed Ketamine in the Face of Tolerance

M

miniko

Greenlighter
Joined
Aug 19, 2025
Messages
3
Hi,

First time going beyond lurking on the forums, looking to read advice and experiences from other peeps.

So a little background: I have a history of heavy drug use (SUD) as well as other mental health issues. I recently relapsed after 2 and a half years of sobriety due to not handling the persistent mental anguish I've felt these last 6 months, resorting namely to drugs I've anecdotally found therapeutic (GHB and ketamine) in lieu of the other 2 alternatives presented in front of me: electroconvulsive therapy (ECT), as suggested by the psychiatrist I've been seeing for over 5 years, seeing as, according to him, I had no other pharmacological tools available to me, or suicide as suggested nonstop by my brain.

Ever since this past week of doing K, the suicide ideation and planning has stopped but I'm aware that I have no "self-control" when it comes to managing psychoactive substances on my own (especially ones I've acquired illicitly and for which I don't have a proper posology), and therefore it'll only be a matter of time before I sink myself back down into the bog of addiction.

I wanna get back to the psychiatrist and bring up prescribed ketamine as an option for my bouts of depression, but am also faced with the conundrum of having now quickly increased my tolerance to K by a LOT over this past week (each dose has roughly increased by about 400% and no longer provide the same intensity of effects). So my concern is that my recent K abuse would interfere with medically prescribed doses.

What're your experiences with this sort of crossover? How did you manage the dose/effect response? I'm guessing a break to lower tolerance is going to be necessary and, if so, for how long in your experience/opinion?

As an extra bit of info: I feel I surprisingly didn't experience "permatolerance" in that the initial hits were similar to my first times on K after having taken this nearly 3-year long break. However, the tolerance ramped up quickly, as described above, just from doing K about 3x/day. Also, in case it might occur to someone, I'm uninterested in turning to AA/the 12-step program or any other sort of "self-help" community atm.

Thanks <3
 
Sounds like you didn't use the ketamine for therapeutic benefits at three times a day. I can see a binge weekend at three days in a row or eod for a few days but that's the max

You said it in your wording . You're going to have to cut back and come off completely. It takes mental discipline. If you do not have mental discipline you don't belong doing drugs, period
 
Chris Timothy said:
Meditation and breath control are ridiculously easy nowadays in the age of AI.
Click to expand...
I do and have done both before the "age of AI", I've even willingly spent my money to go to therapy and develop alternative strategies for my habitual patterns. Pretty much everything besides electroconvulsive therapy thus far. Honestly unsure as to what you mean to say, seeing as it hasn't really answered my question.
 
My apologies, I did miss the point there indeed.

I've barged into a purely-therapeutic ketamine protocol replication before with ACHs tolerance.

It did the trick, as in the depression did go away. It's just not recreational in any way, and I got sick of the water needed to sustain the habit a week in.
 
Chris Timothy said:
My apologies, I did miss the point there indeed.

I've barged into a purely-therapeutic ketamine protocol replication before with ACHs tolerance.

It did the trick, as in the depression did go away. It's just not recreational in any way, and I got sick of the water needed to sustain the habit a week in.
Click to expand...
Thanks, I appreciate the feedback. I understand I may well face that challenge of disassociating therapeutic benefits from an anticipated high, even if my objective is to experience the former. Having said that, do you have any experience, or know of other's experiences, when it comes to a suggested (minimum) period of abstinence from illicit ketamine self-administration prior to professional intervention, so as to minimize the interference of illicit ketamine use on its treatment potential?
 
Not really.

The rule of thumb is two years.

You can speed it up with regenerative bio hacks like fasting/keto diet and supplements and whatnot. But of course that's quite the commitment bringing along opportunity costs.
 
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