Opioids Settle a dispute for me regarding methadone "blocking" other opiates

[velocity92c]

I understand methadone doesn't "block" opiates in a traditional sense but I know it has one of, if not the most, affable holds on your opiate receptors which prevents other opiates from filling them, and thus makes doing them pointless.

However, I have a friend who doses up to 80mg of methadone at a time and then snorts oxys or eats vicodin on top of it and swears that he feels them just as strongly as he normally would. I know this has to be false, because I've been in MMT before and I wasn't able to get ANY kind of buzz from opiates for DAYS after stopping my dose. Even without MMT my experience has been that Methadone prevented me from getting high after a single dose. I've even IV'd a good amount of heroin 12 hours after dosing 40mg of methadone and felt literally nothing.

So can someone settle this debate for me? I hate to see him wasting money on opiates after dosing methadone when I believe the high he is feeling is from the methadone itself. He loves methadone, but I think he is mistaken here. Maybe I'm the one that's wrong though, that's why I'm posting here today. Thanks for your help.

 

[dielonnn]

That is weird that you felt absolutely nothing at all I just did 50 mg of methadone and 7 hours later iv 30 oxycodone and definitely felt it it definitely boosted my high very nicely I do kno that most ppl tho do say methadone does have some effect on being able to not get high as easily

 

[velocity92c]

I'm no expert but from what I've read, any decent amount of methadone (30mg or more) will cling to your receptors as hard or harder than any other opiate out there, so while it's not technically "blocking" it, its hold on your receptors is so affable other opiates cannot cling to the receptors to give you a buzz.

I guess I could be totally wrong on this, but I experimented with this many times, both while on MMT and with single doses of Methadone. I know everybody's body is different but I've heard from many people that have taken methadone that it blocked out their ability to feel other opiates as well. I would like some more input on this though.

 

[rachamim]

70mgs. is the average blocking dosage but it has to (consumed on a regular basis to reach the therapeutic stage known as "Optimiised Dosing," at which point there will be a biological resevoir that mimics a time-release (a steady flow will be disyributed to the blood stream).

The OP explains the blocking process correctly, the super-affinity for relevant receptors, etc. but people that say "methadone doesn't block" are merely playing with semantics. At Optimised Dosing can a subject feel a normal dosage of another opioid/opiate? No, why not? Methadone, so the "block/does not block" game is silly (not talking to the OP who already seems to realise this).