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  • BDD Moderators: Keif’ Richards | negrogesic

Serotonin syndrome help

C

Cubdeer1468

Greenlighter
Joined
Mar 19, 2019
Messages
15
I take oxycodone daily. I occasionally take tramadol or kratom for a few days to give my body a break. I also have a supplement I take with ashwagnda in it. I've taken tramadol with this supplement before and never had a bad reaction. But yesterday around noon I took a dose of Tramadol and I had taken my supplements earlier. I felt weird within 30 minutes like something wasn't right. I have panic attacks occasionally so I thought maybe I'm just freaking myself out. But my temp went up to 99.1 , I've had diarrhea, hot flashes, chills, screens look too bright at times. Today my temp is fluctuating between 98.1 and 99.1. I think today I might just be in withdrawal from no pills in 24 hours. How long should I wait to take more oxy to be safe. Do you have to go to hospital for mild serotonin? I figured no seizures and no temp over 100 I was ok. But now I'm concerned because I read oxy can effect serotonin so I'm not sure if I can take it anymore after this or just wait a certain number of days. I take nothing else other than ibuprofen occasionally. I don't drink or smoke either.
 
Hey I just saw you reply on my thread. I can't definitively say idk i still don't have much of a clue. There is a post from another blue light member that sounds alot like yours and he was experiencing seretonin syndrome.

I'm glad your alive and well. I mean what would have given it to you though? Is aswaghanda seretogenic?

I tried looking at interactions of aswaghanda and opiods and it said increased drowsiness but nothing about seretoning syndrome. Maybe stop all drug intake for a bit to see if everything chills out.
 
A typical normal human body temperature is around 98.6°F (37°C), but it can naturally fluctuate throughout the day. The generally accepted normal range is:
• 97°F to 99°F (36.1°C to 37.2°C) for oral temperature
• 96°F to 98°F (35.6°C to 37°C) for axillary (armpit) temperature
• 97.3°F to 100.2°F (36.3°C to 37.9°C) for rectal or ear temperature

A temperature below 95°F (35°C) is considered hypothermia, while above 100.4°F (38°C) is considered fever. However, some minor deviations can still be normal depending on factors like time of day, activity level, menstrual cycle, and method of measurement.

What you’re experiencing though sounds more like dopesickness.

Maybe the tramadol isn’t covering the sickness like it used to. Try taking some of the oxycodone and maybe try stretching your script instead of relying on tramadol and kratom or whatever.
 
I think its specifically because of the tramadol since it acts as a mild antidepressant unlike other opiates. But I read opiates can effect ssri serotonin too. But it's hard to know. Maybe I just gave myself a panic attack. I tend to get these about once a month but usually I feel normal in a few hours. I still feel pretty weird and it's been 24 hours now.
 
helpingout said:
A typical normal human body temperature is around 98.6°F (37°C), but it can naturally fluctuate throughout the day. The generally accepted normal range is:
• 97°F to 99°F (36.1°C to 37.2°C) for oral temperature
• 96°F to 98°F (35.6°C to 37°C) for axillary (armpit) temperature
• 97.3°F to 100.2°F (36.3°C to 37.9°C) for rectal or ear temperature

A temperature below 95°F (35°C) is considered hypothermia, while above 100.4°F (38°C) is considered fever. However, some minor deviations can still be normal depending on factors like time of day, activity level, menstrual cycle, and method of measurement.

What you’re experiencing though sounds more like dopesickness.

Maybe the tramadol isn’t covering the sickness like it used to. Try taking some of the oxycodone and maybe try stretching your script instead of relying on tramadol and kratom or whatever.
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Yea I always felt better about taking breaks to reduce tylenol consumption and tolerance. But this has really freaked me out. I didn't realize ashwaganda had serogenic properties. I don't even taketh supplement for that, it was because of the vitamins and tyrosine.
 
Cubdeer1468 said:
Yea I always felt better about taking breaks to reduce tylenol consumption and tolerance. But this has really freaked me out. I didn't realize ashwaganda had serogenic properties. I don't even taketh supplement for that, it was because of the vitamins and tyrosine.
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I found ashwaghanda to be helpful for kicking dope. I never took it while I was on dope.
 
Ashwaghanda also raises serotonin, I wouldn't combine it with tramadol. I have had similar reactions from ashwaganda and other drugs.

I would wait as long as you can before taking oxy as it could come back.

I'd also have someone watching you, because SS can get so bad you may not be able to call 911 yourself.
 
Quasimoto said:
Ashwaghanda also raises serotonin, I wouldn't combine it with tramadol. I have had similar reactions from ashwaganda and other drugs.

I would wait as long as you can before taking oxy as it could come back.

I'd also have someone watching you, because SS can get so bad you may not be able to call 911 yourself.
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Do you think waiting 48 hours is enough time? Or how long do you think I need to wait? I definitely learned aswaganda is not harmless. I left a review on Amazon to warn others. I dont know why there isn't a warning for anything that effects serotonin.
 
Oxy has caused serotonin syndrome like reactions in myself during high doses and stimulant like effects. Anecdotal but none of the other mu agonists do this to me

I would use a different mu agonist if you can get it…even better yet a benzo
 
Cubdeer1468 said:
Do you think waiting 48 hours is enough time?
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I have no idea, that's up to your body and how much is in your system.

I would definitely not use any tramadol any time soon. But once you're at the threshold of SS, any opioid can set it off again.

There are even case reports of therapeutic doses of loperamide causing SS, and that doesn't even cross the BBB. It generates serotonin peripherally which then goes to the brain.
 
LucidSDreamr said:
Oxy has caused serotonin syndrome like reactions in myself during high doses and stimulant like effects. Anecdotal but none of the other mu agonists do this to me

I would use a different mu agonist if you can get it…even better yet a benzo
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I never take more than 10 mg every 4 hours but usually less, usually only 7.5 mg every 4 hours. The only things I can get are tramadol, kratom and oxycodone. I do have some ativan but only like 10 pills. When would it be safe to try taking oxycodone again? I don't think I can work without it. Thankfully today and tomorrow I can slack off and not do much to recover but after that I will really need to go back to work.
 
Quasimoto said:
I have no idea, that's up to your body and how much is in your system.

I would definitely not use any tramadol any time soon. But once you're at the threshold of SS, any opioid can set it off again.

There are even case reports of therapeutic doses of loperamide causing SS, and that doesn't even cross the BBB. It generates serotonin peripherally which then goes to the brain.
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Is it something I will always be susceptible to now? Is there anything I can do or is my options to just try to get off opiates all together now?
 
Cubdeer1468 said:
Is it something I will always be susceptible to now? Is there anything I can do or is my options to just try to get off opiates all together now?
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You won't be susceptible forever. Your serotonin levels will eventually normalize if you stop taking what is causing it. I believe even in the most severe cases people recover in a couple days.
 
LucidSDreamr said:
Oxy has caused serotonin syndrome like reactions in myself during high doses and stimulant like effects. Anecdotal but none of the other mu agonists do this to me

I would use a different mu agonist if you can get it…even better yet a benzo
Click to expand...
Your the person i was referencing o saw your post about the syndrome. It seems we all have it lol.
 
Cubdeer1468 said:
I never take more than 10 mg every 4 hours but usually less, usually only 7.5 mg every 4 hours. The only things I can get are tramadol, kratom and oxycodone. I do have some ativan but only like 10 pills. When would it be safe to try taking oxycodone again? I don't think I can work without it. Thankfully today and tomorrow I can slack off and not do much to recover but after that I will really need to go back to work.
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That’s a really low dose. I wouldn’t worry about it. I would get this from abuse level doses of 30 to 80 mg.

The Kratom and tramadol are likely your culprits…are you dependent on either of them because they have a withdrawal that involves more than just opioid withdrawal; so is there any chance your distress is actually a withdrawl from Kratom or tramadol?

Mixing Kratom with any other opioid was always nasty mix for me when I used to do Kratom
 
LucidSDreamr said:
That’s a really low dose. I wouldn’t worry about it. I would get this from abuse level doses of 30 to 80 mg.

The Kratom and tramadol are likely your culprits…are you dependent on either of them because they have a withdrawal that involves more than just opioid withdrawal; so is there any chance your distress is actually a withdrawl from Kratom or tramadol?

Mixing Kratom with any other opioid was always nasty mix for me when I used to do Kratom
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No I only take kratom or tramadols for a few days a month. Sometimes I go two months. I just tried to reduce being on oxy everyday. It's been 32 hours since I took a tramadol. It's been over a month since I had kratom. Its possible my symptoms were psychological since i never had a fever over 100 or siezures or anything. But I definitely felt very wrong. But maybe my body just wanted oxy. I'm in really bad withdrawal from opiates for sure now. I'm sweating and getting horrible hot flashes and anxiety. I was trying to make it to 48 hours but I'm probably going to have to take something and hope it goes ok. I will probably take only 5 mg oxy.
 
I have not read quite everything but

1) ashwagandha has some serotonergic properties-I don't know exactly what, but could present risk in certain combinations and with certain conditions-which sounds like what happened too.
2) I have been claimed two or three times that oxy has serotonergic properties. This has never been proven after the topic has been discussed through, either here or some other platform, with proper links to sources. But I can not straight forward tell that peoples anecdotal experiences ain't worth anything either.
3) Tramadol is then SNRI which also decreases gaba secretion as mu-agonist, just like any other opioid decreases gaba secretion, which can also contribute to serotonin syndrome but should not be sole cause of it. Tramadol is also 5ht3-antagonist, which also decreases seizure threshold.
 
Quasimoto said:
Ashwaghanda also raises serotonin, I wouldn't combine it with tramadol. I have had similar reactions from ashwaganda and other drugs.

I would wait as long as you can before taking oxy as it could come back.

I'd also have someone watching you, because SS can get so bad you may not be able to call 911 yourself.
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Right, but somehow you enjoy LSD type drugs and laugh at the suggestion to have an antiserotonergic drug (trip killers)around in case of a bad reaction
 
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