N&PD Moderators: Skorpio
Serotonin Creatinine Sulfate
mulberryman
Bluelighter
Serotonin Creatinine Sulfate, or 5-Hydroxytryptamine Creatinine Sulfate; 3-2-Aminoethyl-5-hydroxyindole Serotonin ( C14H19N5O2•H2SO4•H2O )
So does this have potential?
LuxEtVeritas
Bluelighter
to cause unwanted problems?
yes
mulberryman
Bluelighter
^ granted anything can cause problems.
Would this cross the BBB?
LuxEtVeritas
Bluelighter
no, and if taken orally most will i believe be separated into their respective components in the stomachas the ionic bonds will break in the HCl
mulberryman
Bluelighter
IV perhaps, doesn't creatine cross the BBB?
mulberryman
Bluelighter
Isn't the reason serotonin doesn't 'get you high' because it doesn't cross the BBB...
Morninggloryseed
Bluelight Crew
Eating serotonin isn't going to get it across the BBB. Doesn't matter what salt/ester/form it is in. Adding a simple carbon atom however to that 5-Ho will result in an active material...and it is called alpha-O-dimethylserotonin (A,O-DMS aka 5-MeO-AMT.)
Serotonin in and of itself is only 'active' an a neurotransmitter so I'm not sure why the interest.
Ham-milton
Bluelighter
morninggloryseed said:
Exactly. I don't understand what the sudden interest in eating neurotransmitters around here is. GABA, L-Dopa, whatever that tryptophan derivative is (I'm not bothering to look it up), now Serotonin in it's active form?
I mean, what is there to make you think serotonin would make you high? Do SSRIs get you high? They'll give you about the same effect.
The only NT with any real chance of getting you high (if it crossed the BBB) would be GABA. Maybe dopamine, but considering the psychotic side effects of L-dopa, who'd fuck with that?
izo
Bluelighter
while this is defenitely true for l-dopa, other natural 5ht and dopamine precursors seem to have 'potential' from what i heard:
5htp and tyrosine are instantly active while tryptophan and phenylalanine seem to work slower due to metabolic pathways. can someone verify that based on personal experience?
i remember 5htp beeing beyond the rate limiting step in 5ht biosynthesis while with da conversion tyrosine to l-dopa is the bottleneck.
this does in no way imply that one might benefit from taking one of this substances. a normal diet is sufficient for enough phe and trp.
indelibleface
Bluelight Crew
It's common knowledge here that MDMA's pharmacology is unique in that it doesn't just release serotonin. There's several materials that just release serotonin, and they aren't that much fun. And, hell, when you eat enough 5-HTP, which does get metabolized into serotonin in your head, you feel downright awful.
mulberryman
Bluelighter
I'd say that ime, consuming 5-HTP, GABA, inositol, niacin, and tyrosine with St Johns wort, all very readily available here, produces a profound effect. I'm sure someone will now claim that I'm retarded or something and killing my brain cells, bla bla bla, but in the end, I can feel myself getting stronger and smarter, and indeed healthier despite putting on some pounds lately, I feel ready to take on the world. ...well, maybe after I pop some tylenol.....
mulberryman
Bluelighter
morninggloryseed said:
So, hypothetically speaking, how might one go about attaching that carbon atom?...
planckunit
Bluelighter
Yes? And how has the alpha-methyl magically appeared in a,o-DMS? Don't you think it would be "5-MeO-T" if just the 5-ho was methylated??
morninggloryseed said:
