Seroquel for Dexedrine comedown, did I do something wrong?

[Archibald The Grim]

Hey folks! Thanks for lending an ear... I'll try to keep this concise. If you think this fits better in Other Drugs (amphetamines), just let me know.

Yesterday, I binged on about 80-90mg Dexedrine XR between 6 and 11pm. Excepting the first two caps which I merely attempted to chew, I did a fair job of crushing the spansules and ingesting the separated powder intranasally, and the remainder orally. In the hopes of catching a little rest, I tentatively tool 12.5mg Seroquel at 1:15. I continued taking 12.5 to 25 mg every 30 mins or so until I was at, I believe, 112.5mg by 2:30pm. It finally seemed to be taking me in the advertised direction of Mr Sandman. But, not long after lying down, I suddenly flipped back to being widely alert again and agitated. In the next hour or so, my pulse skyrocketed and would not slow down. I was short of breath, developed a pounding headache, and my blood pressure was either very low or very high (I think low as I felt like I may faint, but it felt high in terms of the pulse and headache). This persisted relentlessly for hours, like an unending panic attack that makes you feel as though you are dying.

I couldn't take it anymore and didn't know what to do, so around 7am I returned to the dexedrine, redosing 30-40mg in the next hour. It made me feel MUCH better.

The facts: I drank plenty of water. I took vitamins. My tolerance was low. My blood pressure has been whacked lately due to taking an ECA (ephedrine) stack as a poor man's adderall. This was my first experience with Dexedrine, and I LOVED it. If I had simply stayed up all night on the Dex, even coasting on only what I had already taken, I am sure I would feel much better right now. Presently, and surely for the day, I feel like SHIT. At least I don't feel like I'm dying anymore. This was also my first experience with Seroquel.

I read up a LOT on these compounds, literally hundreds if not thousands of posts (I feel like I know all of you already! ;-). I've been trying to ascertain if the problem was perhaps...

1. the ER spansules were still in my system (or I took it too soon after my last dex dose) and the dex fought hard against the seroquel, neither won but I lost
2. I ultimately took TOO MUCH of the Seroquel (I'm prescribed 25-50mg at night for sleep, and strangely another 12.5 during the day) and it pushed me into dysphoria/akathysia mode... (if so, does that mean 50mg would have left me better off?)
3. I took TOO LITTLE of the Seroquel and should have shot for 200mg or so.
4. I took it too late after my last dex dose.

I seem to find anecdotes, science, and convincing perspectives on almost all of these possibilities. I am asking because I need to decide if I want to try again with the Seroquel tonight. I have been entertaining taking 125-175 all at once. But perhaps I should just try 50 since that can't be any worse than what I went thru last night... (right?). I missed work today because of this reaction -- I could have easily pulled today off had I just stayed up all night, even on caffeine. I am in super-yucky-angsty-painful-shitty-tweaker mode now and I hate how my first experience with Dex turned sour. It's definitely my favorite.

Thanks for listenin'!

 

[Selfless]

1. correct
2. I do think you took too much Seroquil, it really is very powerful, but less wouldn't have made you sleep.
3. Too late? Too early.

In a nutshell what it sounds like to me:

You took a fairly large dose if you have a low tolerance. Snorting ER Dex does not defeat the time release, and ER dex will last at LEAST 6 hours. The Seroquil, while an extremely powerful substance, was not enough to make you sleep - and for good reason: you're at the peak of taking amphetamine, your blood pressure and heart rate are high.

To make matters worse, you took a huge amount of Seroquil and now your derping around on an antipsychotic while still very much peaking from a large amphetamine dose.

I think you misinterpret seroquil's uses.. it's not ment to cut an amph high short, but it can end the worst amph comedown, as well as the worst trip.

Moral of the story: Don't take a drug if you aren't prepared for it's duration. Seroquil is not meant to end amp doses while they are still going strong.

Please, be more careful, you took a huge amount of Seroquil for a first time. HUGE. The first (and only) time I took Seroquil, I took 25mg and slept 12 hours straight. I can only imagine what being on that dose of seroquil is like while coming down from the horrible comedown from ER dex, or addy, it's only natural the anxiety would be x10 worse than normal. If you take a large ER dex dose, be prepared to stay up for 6-8 hours. It's not like seroquil slows down your heart beat or blood pressure.

 

[Selfless]

ER Dex is enjoyable for a good 6 hours anyway before shittiness starts to come. Why end it at 2 hours?

 

[Archibald The Grim]

I was having a lovely time, indeed... but I was worried about being bent the next day at work, and historically even 1-2 hours of shuteye is better than nothing. Since it's a relatively new job and I'm not even casually comfortable with my coworkers, I overanalyzed the situation and decided it would be reckless to go in without sleep. I read so much about Seroquel, I must have gotten my wires crossed. I read quite a few reports (and amateur scientist analyses) on how it could/would nullify an amphetamine high. Stop it in its tracks. Sometimes too much (mis)information is as bad as not enough information. I was so overwhelmed by the negativity of the experience this morning, I knew I had done something horribly wrong. But since my misstep was such a surprise to me, I couldn't hope to trust my own analysis of the issue, so thank you so much for helping me find my footing. I'm quite sure you are correct.

I'm also still learning how to gauge dexedrine's effects. Since it can be so much more subtle than adderall (and the god-awful ephedrine I've been taking), it threw me off more than once to where I actually couldn't tell if I was "feeling it". I was looking for the nasty side effects I'm used to as confirmation, but eventually realized how profoundly more in-my-own-skin, collected and capable I felt. Because I never felt agitated, in the end, I misread the high. I wasn't sure what to do with it yet. I'm not used to feeling relaxed, adroit, happy, and relatively pain free, and certainly not at the same time.

So, since I'm an insomniac anyway, I thought I was doing *the right thing*, the *responsible* thing, by taking what seemed to be an opportunity to abort the dex, crash out, and avoid potentiall "fiending"... which I have been notorious for pretty much since I first tried snorting Pixie Sticks as a child (true story). Thus far, the itch to keep pushing and "DO IT ALL!" is actually manageable. I hope that continues.

Thank you again for helping me see things clearly. Your explanation really aligns with my experience and allays my distress at not understanding. My day just got a lot less shitty thanks to you.