seroquel & dopamine

[allone]

i just came out of the mental institution for a 3rd time and this time around i decided to actually experiment with seroquel over there because the doctor said if i dont take it straight for 3 days, he wont let me out!
So anyway I had to do what I had to do. I took it 3 days straight. And It made me FUCKING FEEL LIKE SHIT!!!

BUT CHECK THIS STUDY; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5305132/

people can abuse it to create dopamine, really??
so far, it doesnt work for me! ive just tried tianeptine for a first time in a week since i was in the mental ward, and IT DOESNT FUCKING WORK. and keep in mind, tianeptine is my number one chemical to test my dopamine levels all the time. SO, this one is probably a flux, no?? maybe its just me....

 

[plumbus-nine]

You can't "abuse" quetiapine. People use this shit to spend some less hours experiencing the shit they are in but it's the antihistamine component they're taking it for, the D2 antagonism just sucks imho. Quetiapine "abuse" is frequent in prisons etc..
Oh, I too was forced to use it, more than 10 years ago but it could have killed me. Couldn't walk straight anymore when these asses finally discharged me to drive home (600mg/d). Got fine panic attacks later, something not even yohimbine was able to induce. Somebody I know went catatonic from seroquel "abuse", she was desperate and took multiple times her 500mg's.

Quetiapine abuse gets you, by frequency:
- Drowsiness/lethargy
- Tachycardia (due to NET blockade from metabolite likely)
- Slurred speech
- Hypotension
- Agitation/Irritability
etc..

 

[Jabberwocky]

You might find this article useful as well - even though it is about seroquel, dopamine and rats. But it talks about a possible mecahnism of action for seroquel in alleviating depression via dopamine even though it is thought to block dopamine transmission.

Divergent effects of acute and repeated quetiapine treatment on dopamine neuron activity in normal vs. chronic mild stress induced hypodopaminergic states - Translational Psychiatry

Clinical evidence supports the use of second-generation dopamine D2 receptor antagonists (D2RAs) as adjunctive therapy or in some cases monotherapy in patients with depression. However, the mechanism for the clinical antidepressant effect of D2RAs remains unclear. Specifically, given...

www.nature.com

 

[plumbus-nine]

Weird paper. Maybe they're describing the additional effects SNRIs have over SSRIs. Remember, a metabolite of quetiapine is a pretty potent NRI.

I had a borderline-euphoric rebound after stopping like 4x 25mg/d quetiapine but attributed it to the antihistamine property. Didn't get that from stopping higher amounts. Maybe there's a sweet spot but it doesn't feel right to attribute anything sweet to this substance, and certainly you won't feel the additional dopaminergic activity until withdrawal, also it lasted only for one day..

Actually, people should try to augment SSRIs with memantine. Don't know why this isn't exploited but venlafaxine + memantine is highly euphoric, borderline recreational, mostly anxiolytic, no crash/jitteriness and tolerance builds very slowly. Maybe these docs just associate D2 & 5ht2a with evil.