Effexor is my favorite antidepressant medication that is currently available. I can understand people might feel blasted away by the medicine after the first few dosages but the body does adjust to it and then everything is back to normal again.
Just for the SAR portfolio, out of all the effexor analogues tested, the dichlorophenyl aromatic substitution pattern was the strongest. The dimethylamine alkaloid pattern is the only one that worked. Cyclohexanol is far and away the best ring size.
Dichlorophenyl was roughly 1:1 Sert:Net. As we have already noted in other posts, the most potent inhibitors dont automatically imply that they are in fact most suitable one. In the case of Effexor, 4-bromophenyl was the most preferable ring substitution pattern. This one had a ratio of SERT:NET 2:1
The beta-adrenergic stimulation from effexor was shown to drop of with repeated dosage regimen (ie. the biometabolism adapts to it).
Just for the SAR portfolio, out of all the effexor analogues tested, the dichlorophenyl aromatic substitution pattern was the strongest. The dimethylamine alkaloid pattern is the only one that worked. Cyclohexanol is far and away the best ring size.
Dichlorophenyl was roughly 1:1 Sert:Net. As we have already noted in other posts, the most potent inhibitors dont automatically imply that they are in fact most suitable one. In the case of Effexor, 4-bromophenyl was the most preferable ring substitution pattern. This one had a ratio of SERT:NET 2:1
The beta-adrenergic stimulation from effexor was shown to drop of with repeated dosage regimen (ie. the biometabolism adapts to it).
