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Seperating the antidepressant effect of Tramadol

U

Unlucky

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Joined
Apr 26, 2007
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Tramadol seems to help for my pain but the antidepressant effects of it disrupts my sleep, mood, temperature (feverish and overheating) and worsens the symptoms of a neurological condition I have.

So I was wondering is it possible to seperate the antidepressant properties of Tramadol from the pain releiveing properties or is the whole thing integrated acting together in releiveing pain?

I found this article that suggests that tramadol has many of the pre- and postsynaptic neurochemical features of a conventional antidepressant but im wondering if this can be seperated or removed out.

http://opioids.com/tramadol/ultramantidep.html
 
o-desmethyl tramadol is far more potent at mu-opioid receptors than tramadol itself. thus, the effective painkilling dose would be far lower, meaning the antidepressant side effects would be greatly reduced.
 
It's really easy to find something like tramadol that doesn't have the SNRI effects. It's called morphine.
 
Hammilton: I've been telling everyone their SSRI properties! There's generally a bit of overlap, do you have the affinities of tramadol to all transporters?


Would the SSRI/SNRI properties of tramadol contribute to the analgesic quality?
 
Ham-milton said:
It's really easy to find something like tramadol that doesn't have the SNRI effects. It's called morphine.
Click to expand...

I didnt want to give everyone my life story once again as I t hink ive done that enough on these forums but for anyone whos missed it...I have a severe chemcical sensitivity and experience adverse reactions to narcotic agents including morphene, codene, hydrocodone, oxycodone, darvocet, tramadol and fentanyl which all started after I developed a neurological condition (autonomic dysfunction) following an overdose to recreational party drugs 8 years ago.

Out of all of these I chose the ones which I have had less severe adverse reactions to and put myself on a desinsitization program to them by taking minute doses everyday, so cureently im working on building up my tolerance to tramdol and fentanyl.
 
that sounds to me like your body/ immune sytem is hypersensitive since then and does produce antibodies to each new aminergic drugs that enter your system.

am i right here?
 
It sems that way, I actually had the same theory as well because I was able to take some of the opioids the first time without incidenece but the second time I had adverse reactions and continued to do so everytime after that, so this aslo leads me to also believe I have developed antibodies to it.

Ok so where do i get myself some of this "o-desmethyl tramadol " what brand names is it manufactured under?
 
^ I don't think their is any pharmaceutical company that makes that, but i've heard a mod say that he brought some pure powder from some online vendor before.

btw have you tried other kinds of opioids like pentazocine (talwin) or butorphanol (stadol) yet?
 
No I havent heard of those or tried those two yet, I also havent tried methadone or buprenorphine. Thanks for the advice, I will see if I can get my Dr to let me trial the ones you mentioned.

Tsukasa...I just read that to avoid others abusing pentazoine the narcotic-antagonist naloxone was added to preparations containing pentazocine, same with suboxone which is a buprenorphine and naloxone combination. I guess my question is...can these medications still be effective for pain relief if they have a narcotic antagonist like naloxone in them?
 
Unlucky said:
Ok so where do i get myself some of this "o-desmethyl tramadol " what brand names is it manufactured under?
Click to expand...
You can't get it anywhere. Its the main metabolite of tramadol, with more opiate effects than the parent compound.
Its not commercialized anywhere, at least not where you live, and you can't obtain it anywhere.
 
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