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Selegiline + Wellbutrin

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wreckhead

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Joined
Dec 22, 2008
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In theory this would massively boost synaptic dopamine (due to Wellbutrin) while only mildly agonising autoreceptors (due to selegiline). The autoreceptor effect could be abolished with a low dose of antipsychotic, e.g. 50mg amisulpride. Wellbutrin would have practically zero noradrenaline effect due to the very low dose used.

You might need memantine/magnesium for tolerance though. Any thoughts? As y'know, in theory this could produce euphoria greater than crack...

Edit: selegiline + low dose antipsychotic alone could have significant abuse potential.
 
You wouldn't die, its fine. Why do you think that it would only mildly agonise the autoreceptors. Is there something I'm missing? Huge dopamine boost => more dopamine activating autoreceptors. I don't see how selegiline avoids this. Also, the theory of amisulpride binding preferentially to autoreceptors is a bit wishy washy, although I guess it has been shown in some studies. However, newer studies have shown that the cause of its anxiolytic and antidepressant properties are due to the fact that it is a potent 5-HT7 antagonist.
 
I would avoid combining selegiline with anything with prominent adrenal-type effects. Hell, clean stimulants are already quite risky.

ebola
 
This guy is obviously a troll, if you've seen his other threads too. Now he thinks mixing several shitty drugs makes some kind of super space-alien drug.

Why not just get some real drugs like some kind of amphetamine, and have fun with that? Don't waste your time with antidepressants and antipsychotics
 
permastoned said:
You wouldn't die, its fine. Why do you think that it would only mildly agonise the autoreceptors. Is there something I'm missing? Huge dopamine boost => more dopamine activating autoreceptors. I don't see how selegiline avoids this. Also, the theory of amisulpride binding preferentially to autoreceptors is a bit wishy washy, although I guess it has been shown in some studies. However, newer studies have shown that the cause of its anxiolytic and antidepressant properties are due to the fact that it is a potent 5-HT7 antagonist.
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Selegiline would activate pre and post-synaptic receptors pretty equally (AFAIK), but Wellbutrin only increases dopamine in the synapse (being a DRI), so shouldn't add to the pre-synaptic effect.

I would avoid combining selegiline with anything with prominent adrenal-type effects. Hell, clean stimulants are already quite risky.
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The Wellbutrin dose I'll be using will be something like 10mg, and that much will have negligible effects on the noradrenaline transporter. Even if I'm wrong and it does provide some inhibition, this would only block selegiline's adrenergic action because selegiline relies on the noradrenaline transporter for these effects (as it's a noradrenaline releaser via metabolites).

This guy is obviously a troll, if you've seen his other threads too. Now he thinks mixing several shitty drugs makes some kind of super space-alien drug.

Why not just get some real drugs like some kind of amphetamine, and have fun with that? Don't waste your time with antidepressants and antipsychotics
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Because this will give better effects than amphetamine, without the shitty adrenergic stimulation? The same would work for Ritalin or amphetamine, but I don't have access to those right now. Wellbutrin is perfectly adequate for this though.

Selegiline + psychostimulant combinations are sometimes used in treatment-resistant depression, FYI.

No, I'm not a "troll". You are the only person that's contributed nothing to this thread.
 
rocknroll714 said:
I think MAOIs and reuptake inhibitors are generally the same when it comes to autoreceptor vs postsynaptic receptor stimulation actually. This would be because monoamine oxidase is found within the neuron, not floating outside, to my knowledge at least.

I'll bet amisulpride + selegiline + bupropion would be highly synergistic.
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Oh right, noted. Yeah that combo would be sweeet; I'll try it in a few months once I'm past drug testing.
 
rocknroll714 said:
He's not a troll. He's actually a really good friend of mine. I suggest you treat him with some respect.
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More like you say he's not a troll, because he's your friend. I won't give someone respect that they don't merit. By your logic it seems you should treat your father with respect even if he was a serial baby rapist, just because he's a member of your family.
 
rocknroll714 said:
I think MAOIs and reuptake inhibitors are generally the same when it comes to autoreceptor vs postsynaptic receptor stimulation actually. This would be because monoamine oxidase is found within the neuron, not floating outside, to my knowledge at least.

I'll bet amisulpride + selegiline + bupropion would be highly synergistic.
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Actually, because autoreceptors are only sensitive to dopamine released from the neuron in which they sit, can you explain why a reuptake inhibitor activates them?

I haven't done any research about autoreceptors so I'm a noob. I just read that on wiki. Is it only that they are activated when they are released, or is it that they are activated even when floating around in the synapse (which would explain why a DRI would activate them, and confirm my original assumption)
 
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^ Ah yeah, that's what I figured originally. Until your friend said I was wrong, so I looked at wikipedia and it said "An autoreceptor is a receptor located on presynaptic nerve cell terminals and serves as a part of a feedback loop in signal transduction. It is sensitive only to those neurotransmitters or hormones that are released by the neuron in whose membrane the autoreceptor sits."

Which is a bit misleading. Thanks for the clearup.
 
rocknroll714 said:
I think MAOIs and reuptake inhibitors are generally the same when it comes to autoreceptor vs postsynaptic receptor stimulation actually. This would be because monoamine oxidase is found within the neuron, not floating outside, to my knowledge at least.

I'll bet amisulpride + selegiline + bupropion would be highly synergistic.
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Or you could substitute the amisulpride with Mirapex, a full D2 agonist.

Isn't combining antagonists with agonists just cancelling each other out?

Why not just get some real drugs like some kind of amphetamine, and have fun with that? Don't waste your time with antidepressants and antipsychotics
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Im gonna have to agree here. I myself am on bupropion and a small dose of deprenyl and while it does have its stimulating effects it is nothing like speed. I works great for my depression and anhedonia though. Both drugs also are also given to help ease withdrawal symptoms from stimulant addicts.
 
That's a scary thought. An addict deciding to get high while on deprenyl is a dead addict.
 
That's the point. 99.9% of them won't, and even if they've been told, as a group addicts tend to be risk takers. Potentiation to them may sound like a better time, even if they've been adequately informed of the risks.

I could probably take heroin quaaludes and drink some vodka and be fine, but would most? NO fucking way.
 
By the time you hit 15mg / day you've long effectively had total MAO-B inhibition and crossed into MAO-A territory.
 
^ Prove it please? Do you realise that I am quite a large guy, and it has always taken large amounts of substances to affect me compared to other people.

Some people have much higher levels of MAO than others, this has been shown in many studies.

Furthermore, the studies about the selectivity of selegiline for MAO B were all done in the elderly.
 
Advanc3d said:
i have taken 5mg of selegiline while on 300mg of bupropion, i honestly felt more "tired" than anything
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I'm on 150mg bupropion(low dose, can't handle the 300mg) and 2.5mg deprenyl. Sometimes Ill skip a day for the deprenyl cause MAOI last for a while and I don't want to get a "spillover" effect by taking it everyday. I also take a half a pill of celexa to help with anxiety. Going over 5mg of selegiline would be playing with fire for me so I have to stay low dose with everything.
 
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