Selegiline to prevent neurotoxicity?

[badrobot114]

Found a couple of interesting papers, i'll link one of them(can look up the other one if people really want) basically stating l-deprenyl(selegiline) at MAO-B inhibiting doses(no more than 10mg) taken 30 mins before MDMA completely blocked the neurotoxic effects. I have also found one positive account on reddit from someone who tried it.

The aforementioned paper:
http://www.ncbi.nlm.nih.gov/pubmed/7538579

The user account on Reddit:
http://www.reddit.com/r/DrugNerds/comments/1eau4s/selegiline_to_prevent_mdma_neurotoxicity/

Any thoughts on the matter? anyone experimented with it and cares to share his conclusions?

 

[JWills20]

More appropriate for the Neuroscience & Pharmacology mandems so i'm sending it over there. It appears a good idea if you know what you're doing. But it is extremely important that doses are low so that it is selective to dopamine and not serotonin too. Or SS would become a realistic problem. It also appears to potentiate MDMA alot, so that you'd really need to know your shit in the dosing department.

 

[endotropic]

In my opinion the biggest problem with combining an MAOi with ecstasy is that the user generally has no way of confirming that they are in fact taking MDMA, which might be safe, or something else entirely, which may not be.

If you have pure, confirmed MDMA you might be able to do this safely. If you have anything else I think this is asking for trouble.

 

[cosmosmariner]

Good point on the purity. I have tried this combo several times. I have yet to have any after effects from a 240 mg night at 140 lbs. : )

 

[badrobot114]

Obviously i'm talking about taking no more than 5mg 30 mins before administrating MDMA, ensuring selective MAO-B inhibition. And all this assuming of course one is measuring doses on a reliable scale and ingesting pure MDMA.

In theory, doing this one would minimize the production of toxic metabolites and use a smaller amount of MDMA which seems as ideal as possible.

 

[ebola?]

selegiline is an irreversible inhibitor, so it's more that enzymatic inhibition accumulates with successive dosing. You need to be more careful when you do this:

http://www.bluelight.ru/vb/threads/600220-Safer-Use-of-Stimulants-FAQ-revised

ebola

 

[Hammilton]

Is there any real e evidence that selectivity is lost with longer term dosing?

 

[tweex]

It is not, it only loses selectivity and inhibits MAO-A with higher dosages.

I've been on selegiline 5mg/day for many weeks now. I'm a huge fan.

 

[ebola?]

Is there any real e evidence that selectivity is lost with longer term dosing?

No, I would only suspect such with successive dosing near the threshold for loss of selectivity. But the logic of its activity suggest such, with less available preferred target of activity?

ebola