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Selegiline---- Panacea ?

stillbeing

stillbeing

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Joined
Mar 20, 2004
Messages
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New York USA
Is everything about it true?

i know it's an antidepressant but how about

Totally repairs damage done by E and meth

extends life ( I know it does in model animal groups)

Increases sex drive

etc etc etc


and a personal question :

why would my Dr say that b/c I am slightly Bipolar ( maybe cyclothymic , have ups and downs )
that I should not try this medication ??

She said this after I said I had once been on Prozac in 1991 and it was a nightmare.

but the drug she did put me on is HORRIBLE for me ( Lamictal ) my second week of it I have 10 side effects which suck ( like back pain neck pain and even headaches which last 12 hours, so i am going to have to QUIT it now. )


I want to try the EMSAM ( selegiline ) !!!!!!!!!! :)
 
stillbeing said:
Is everything about it true?

i know it's an antidepressant but how about

Totally repairs damage done by E and meth

extends life ( I know it does in model animal groups)

Increases sex drive

etc etc etc
Click to expand...

its not a magic pill !

it is very subtle over the long term, although the first few days it got me high, but that quickly wore off.
 
It gets metabolized into amphetamines, so it can make some people feel very good... so people who take it like to say it's really good.

The evidence that it is neuroprotectant in general is pretty weak..

thoughs side effects from lamictal/lamotrigine are pretty weird... but stick to the drugs that your doctor prescribes (though obviously, you need a new drug), at least for a while, and at least until you've tried the classical treatments, like depakote and lithium...
 
No, Deprenyl is not a panacea.

It certainly does everything you said, except for repairing damage from E and speed, of course. It certainly seems to protect it you take it beforehand (subjective feeling confirmed by friends), but as far as repairing fried synapses and a wired CNS, I highly doubt it.
 
BilZor , thanks , voice of reason , as always. which is good , since I'm not, usually !
Others : as far as the repair to damage done by meth and E. I did not make that up , of course, i guess I saw it in an abstract , but maybe I read it hastily .
about the anti aging effects: if it has shown itself to extend the lives of lab animals between 7 and 40 % depending on the species



why isnt it drawing more attention in the public --as a possible life extender ( since many people are in no hurry to die ) ??
yes it made alll the newspapers when it was announced as an antidepressant EMSAM ( emsan ?) Patch ( USA approval ) a few weeks ago .

how about the life extention ????( hate to sound gullible but -- hmmm )
 
Considering the extent of life-extension, the hazards with combinations will probably kill a good number of unknowing persons. Contraindications with food and drugs are a big inconvenience when it comes to MAOI's.
 
considering that potentially, i have eaten more l-dep than anyone on this board, i'll say that it is very far from being a panacea.

that said, it is one interesting molecule, with discernable health / cognition beneficial properties.
 
thanks , nanobrain, I have gone back and read all of your posts on it .

There was a small snag when I got (somewhere ) to your having had PSYCHIC experiences , only because I am a sceptic in that area ( even though I have had them a couple times myself --i still barely, if at all, believe in it . )

all of yr other info was most helpful, you cornered the market on that one. may I ask for a bit more :

are you taking it now ?

do you ever have a regret about taking it ( of course your physiology differs from mine and everyone elses ) ( I'm only looking for a WHY ? if you have had any regrets ---- not expecting anything other than subjectivity )

do you know anyone prescribed for it and on the new patch form, and are they happy with it ?

I will be seeing my DR in with 5 to 10 days to ask for a whole list from her of drugs she would consider for me to try for my Prismatic mental condition which ranges from Vastly Supreme to GADS to Cyclothymic disorder (mild bipolar )

I know I am getting my hopes up early but basically I think there may be a substance which would----------


a) keep me away from OTHER substances

( meth ---or etc ) (for a while or forever )
b) keep me from sinking into Darkness every 4 to 8 weeks.
c) keep me from procrastinating
c) help me think with the clarity I had two years ago on neurontin and coffee ( Quit coffee in september -- became harsh (( harsher than meth ? YEP !) )
d ) Do my dishes for me and turn Lead into Gold ! okay kiddin '

Thanks All.
 
stillbeing said:
I will be seeing my DR in with 5 to 10 days to ask for a whole list from her of drugs she would consider for me to try for my Prismatic mental condition which ranges from Vastly Supreme to GADS to Cyclothymic disorder (mild bipolar )

I know I am getting my hopes up early but basically I think there may be a substance which would----------

a) keep me away from OTHER substances
( meth ---or etc ) (for a while or forever )
b) keep me from sinking into Darkness every 4 to 8 weeks.
c) keep me from procrastinating
c) help me think with the clarity I had two years ago on neurontin and coffee ( Quit coffee in september -- became harsh (( harsher than meth ? YEP !) )
d ) Do my dishes for me and turn Lead into Gold ! okay kiddin '

Thanks All.
Click to expand...

i got a friend with very similar symptoms as you, who has tried many different medications (that have failed over the long term), but one combo that has worked in the long term is Sodium Valproate and Dex-amphetamine together. Great combo for people like you.
 
thanks dr beat . i have been hearing this from people a lot lately and I have an appointement with my Dr in 6 days and will discuss, this. I hope she is not anti dexamphet because I cannot function at my job in a dozey sleepy state. and I hope I can sleep well at nights w/o benzo as an aid. if I get put on dexamphet. assuming the sod valpro will help with the sleep
 
stillbeing said:
thanks dr beat . i have been hearing this from people a lot lately and I have an appointement with my Dr in 6 days and will discuss, this. I hope she is not anti dexamphet because I cannot function at my job in a dozey sleepy state. and I hope I can sleep well at nights w/o benzo as an aid. if I get put on dexamphet. assuming the sod valpro will help with the sleep
Click to expand...

sodium valproate helps with sleep ALOT but you do not get the groggy sleep of benzos' (like valium, ect) so i find it much better for sleep in the long term than benzos' (over years).

Sodium valproate also stops all the bad dex-amphetamine side effects, like getting wound up and getting scattered. It also stops the euphoria of the dex-amphetamine, but it also stops the 'low' comming off dex-amphetamine, which is VERY FUCKING IMPORTANT in my opinion. (i am talking about long term happiness over years, not just being high for a day or two).

On both together you get very good focus, very good attention, long attention, balanced behaviour, and good impulse control, and i personally get no craving to take drugs or drink alcohol, which is great for me. A great combo in my opinion.

1000000000000000000000 times better than SSRI's.
 
thanks a lot ! I will ask her to consider this as my next try . I will see her in two days. Till then , i am hanging in there. Thanks a lot and can I PM you re: this, if I DO get put on it ?
 
stillbeing said:
thanks a lot ! I will ask her to consider this as my next try . I will see her in two days. Till then , i am hanging in there. Thanks a lot and can I PM you re: this, if I DO get put on it ?
Click to expand...

yes you can.

good luck, i hope you got a good psych.
 
stillbeing said:
are you taking it now ?

do you ever have a regret about taking it ( of course your physiology differs from mine and everyone elses ) ( I'm only looking for a WHY ? if you have had any regrets ---- not expecting anything other than subjectivity )

do you know anyone prescribed for it and on the new patch form, and are they happy with it ?

...for me to try for my Prismatic mental condition which ranges from Vastly Supreme to GADS to Cyclothymic disorder (mild bipolar ) I know I am getting my hopes up early but basically I think there may be a substance which would----------

a) keep me away from OTHER substances

( meth ---or etc ) (for a while or forever )
b) keep me from sinking into Darkness every 4 to 8 weeks.
c) keep me from procrastinating
c) help me think with the clarity I had two years ago on neurontin and coffee ( Quit coffee in september -- became harsh (( harsher than meth ? YEP !) )
d ) Do my dishes for me and turn Lead into Gold ! okay kiddin '

Thanks All.
Click to expand...

who diagnosed your ass w/all that crap? sounds like what you need is the giddy up an go to get things done. ie Will to Power.

other nonpharmacological holistic options may well be worth considering.

now, as far as your questions:

yes, i still take and combine selegeline on a rotational schedule.

no regrets other than a few severe acute mishaps when combining with exotics, which noone who values their health should ever do.

i know at least one member of this board prescribed said, who may or may not choose to go into details, i know of noone who gets patch doses.
 
Thanks Nanobrain.

well, for the sake of keeping myself on my currently fairly positive mood, I was not /am not feeling like describing my mental dips and downsides in explicit detail to convince anyone that I need to try some pharms. i have tried a lot a LOT of other things TRUST me . and i have fallen into some very serious self loathing states I will not go into , just TRUST me. and yet , sure sometimes I am happy enough that I get seriously accused of being on something (when I am NOT ). thereis one thing I wanna try . though its not covered by insurance, EMDR ( some people like to debunk it however i do have a friend who just got , in a few weeks , some spectacular results , really truly great , and if it were do to a placebo , I wouldnt even care ! whatever works !

as far as your selegeline use goes : very impressive and inspiring. I wont likely try it . for a long while, but it sure is the most fascinating drug I have read about in a while . ( i may be a bit on the alone side with THAT statement . oh well )
Thanks nanobrain.
SB
 
I'll chip in my 2c. I've taken several courses of selegiline. You do get a mild amphetamine effect in the first few days / week, but that tends to wear off. When I say mild, I do mean mild.

After about 2.5 weeks of selgiline (and NOT drinking -- this is important), something truly hectic happens to my memory. My memory slowly improve for 2.5 weeks or so, but overnight my memory becomes essentially eidetic/photographic.

Now when I say this, I mean I can memorise enormous quantities of information with essentially zero trouble.

For example: I memorised 212 pages of statistical physics notes in two days, and got 97% on the exam. I memorised 180 pages of notes on theoretical quantum mechanics in two and a bit days and got 98% on the exam.

The effect ceases within a few days of stopping the selegiline, and is (interestingly) destroyed by drinking. I went out and had half a bottle of wine one night, and the effect vanished for 3 days, then returned.

I have a good memory normally, and am intelligent, but this sort of feat is not within my grasp.

Perhaps even more interestingly I have the memory without the perception of having learned the material. I don't have the feeling that I know any of it, but when I go to write it down it's all there, with 100% accuracy.

I don't take it for any depression/other psychoaffective disorder.

My girlfriend has also found the same thing, though it takes her just over 3 weeks for the effects to appear.

I realise that this could be some sort of placebo effect, but if it is, it's stronger than anything else I've ever encountered. I never expected it the first time it happened either.

I've never encountered such a memory effect from any other nootropic drug either.
 
VelocideX said:
I'll chip in my 2c. I've taken several courses of selegiline. You do get a mild amphetamine effect in the first few days / week, but that tends to wear off. When I say mild, I do mean mild.

After about 2.5 weeks of selgiline (and NOT drinking -- this is important), something truly hectic happens to my memory. My memory slowly improve for 2.5 weeks or so, but overnight my memory becomes essentially eidetic/photographic.

Now when I say this, I mean I can memorise enormous quantities of information with essentially zero trouble.

For example: I memorised 212 pages of statistical physics notes in two days, and got 97% on the exam. I memorised 180 pages of notes on theoretical quantum mechanics in two and a bit days and got 98% on the exam.

The effect ceases within a few days of stopping the selegiline, and is (interestingly) destroyed by drinking. I went out and had half a bottle of wine one night, and the effect vanished for 3 days, then returned.

I have a good memory normally, and am intelligent, but this sort of feat is not within my grasp.

Perhaps even more interestingly I have the memory without the perception of having learned the material. I don't have the feeling that I know any of it, but when I go to write it down it's all there, with 100% accuracy.

I don't take it for any depression/other psychoaffective disorder.

My girlfriend has also found the same thing, though it takes her just over 3 weeks for the effects to appear.

I realise that this could be some sort of placebo effect, but if it is, it's stronger than anything else I've ever encountered. I never expected it the first time it happened either.

I've never encountered such a memory effect from any other nootropic drug either.
Click to expand...



what happens to that info when you stop taking selegiline? ie how state dependent is it?
 
http://www.sigmaaldrich.com/img/assets/10441/neuro_excerpt.pdf

This document is good at explaining observed phenomena although it only gets as far as the SSRI's and hence is chronologically limited in its coverage.

Selegiline is a selective MAO-B inhibitor meaning that it works on dopamine instead of MAO-A which is the receptor subtype targeted under the tenets laid down by the somewhat predated "monoamine theory" in the treatment of depression.

I think I read that Selegiline is metabolised to the inactive isomer of amphetamine, meaning while it does not directly explain for the stimulant effects of the drug (which are no joke apparently and can be way strong), it can give a false positive in drug tests.

While on the subject of MAOI's and amphetamine, also look at the structure of tranylcypromine.
 
Consider that much of the research that is easy to find online about "Life Extension Drugs" is published or presented by the same groups who are marketing these drugs for profit. I was gullible once and placed an order overseas for some life-extension drugs, but after 3 years of receiving monthly snail-mail "newsletters" and weekly email-spam from these companies (including some I never purchased from) touting the latest and greatest drugs, and accompaning "new scientific findings", I am far more skeptical about the scientific integrity of their evidence.
 
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